[c09aa8]: / clusters / 9knumclustersv2 / clust_2185.txt

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Prior whole-lung or hemi-thorax irradiation of greater than gray (Gy) received less than months prior to consent (focal radiotherapy to the thorax is not an exclusion)
Prior radiation to the breast or thorax.
Patients who have had previous radiotherapy in the thorax
Prior fistula within thorax, including bronchoalveolar or esophageal
Radical radiotherapy to the thorax with curative intent within days of initiation of study drug treatment; palliative radiotherapy for bone lesions outside of the thorax or brain within days of the first dose of study treatment; palliative radiotherapy to the brain or thorax within days of the first dose of study drug treatment
Prior radiation therapy to the abdomen and/or lower thorax
Prior radiotherapy to the thorax such that composite radiation would significantly overdose critical structures, either per estimation of the treating radiation oncologist or defined by failure to meet normal tissue tolerance constraints
The patient cannot have had prior radiation therapy to the thorax or upper abdomen
Prior radiation therapy to the ipsilateral breast or thorax.
INCLUSION CRITERIA (SUBJECTS STRATIFIED INTO THE THORAX HIGH VOLUME TREATMENT SITE)
EXCLUSION CRITERIA (SUBJECTS STRATIFIED INTO THE THORAX HIGH VOLUME TREATMENT SITE)
Prior radiation therapy to the ipsilateral breast or thorax
ELIGIBILITY FOR TREATMENT ON ARM : Ninety days must have passed since the last doses of radiation or chemoradiation treatment involving lung tissue or thorax prior to T cell infusion (to avoid confounding pneumonitis)
Patients with a history of prior radiation therapy to the thorax
Prior radiotherapy to the thorax
Previous radiotherapy to thorax (prior breast radiation therapy [RT] is permitted).
Patients with sarcoma, renal cell carcinoma, or melanoma or with known disease outside the lungs and/or thorax
Tumor sites eligible for inclusion on this protocol include thorax, abdomen, and pelvis
Major surgery or radiation treatment < weeks prior to enrollment; in addition, cannot have received radiation to the thorax or gastrointestinal tract within three months of the first dose of study treatment
No prior radiation to the thorax that would overlap with the current treatment field, prior radiation to other areas is allowed
Prior radiotherapy to the thorax such that composite radiation would significantly over-dose critical structures, either per estimation of the treating radiation oncologist or defined by failure to meet normal tissue tolerance constraints
Patients should have either non-metastatic cancer of the thorax, or metastatic cancer to the thorax and candidate for definitive radiation dose to the thoracic tumor (not palliative intent), tumor radiation dose to at least BEDGy Gy
Must be deemed medically fit for SBRT to the abdomen or thorax by the treating physician
Patients with active disease outside the thorax may be eligible for study once the extrathoracic disease is definitively treated by local modalities such as radiation, surgery, or radiofrequency ablation
Ongoing treatment with radiotherapy to thorax, cytotoxic or biological therapies for this malignancy (Note: hormonal therapy is allowed)
Prior radiation therapy to the ipsilateral breast/nodes or thorax
No prior systemic chemotherapy, radiation therapy to the thorax, or total surgical resection
Patients with a limited (-) number of metastatic foci outside of the thorax who are candidates for consolidative treatment with SBRT
Cancer patients receiving radiation treatment to the thorax to at least Gy; patient must have pathologic confirmation of diagnosis, or have an enlarging lung mass on at least two scans spaced months apart, and FDG avidity on PET scan