History of allergic reactions attributed to compounds of similar chemical or biologic composition to olaparib, cediranib or bevacizumab Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to LY or to its formulation are not eligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to olaparib and ramucirumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to study drugs (e.g. cisplatin) History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN (TAK-) Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab History of allergic reactions attributed to compounds of chemical or biologic composition similar to palbociclib. History of allergic reactions attributed to compounds of similar chemical or biologic composition to brentuximab vedotin History of allergic reactions attributed to compounds of similar chemical or biologic composition to hetIL-. Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib are not eligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to phenelzine or other monoamine oxidase inhibitors History of allergic reactions attributed to compounds of similar chemical or biologic composition to ruxolitinib or trastuzumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to afatinib or docetaxel History of allergic reactions attributed to compounds of similar chemical or biologic composition to GM-CSF History of allergic reactions attributed to compounds of similar chemical or biologic composition to sotatercept, lenalidomide, pomalidomide, or dexamethasone History of allergic reactions attributed to compounds of similar chemical or biologic composition to eribulin History of allergic reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab and trebananib including history of allergic reactions to bacterially produced proteins Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to PT are ineligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to bavituximab Patients may not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to metformin History of allergic reactions attributed to compounds of similar chemical or biologic composition to palbociclib (including abemaciclib) Participants with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to palbociclib, everolimus or exemestane History of allergic reactions attributed to compounds of similar chemical or biologic composition to ramucirumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to selumetinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to bevacizumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to PLX or sirolimus A history of allergic reactions attributed to compounds of similar chemical or biologic composition to docetaxel or carboplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to nab-P. History of allergic reactions attributed to compounds of similar chemical or biologic composition to ponatinib History of clinically significant allergic reactions attributed to compounds of similar chemical or biologic composition to AT or paclitaxel History of allergic reactions attributed to compounds of similar chemical or biologic composition to everolimus Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to brentuximab vedotin and/or rituximab History of allergic reactions or adverse reactions (e.g., wound dehiscence) attributed to compounds of similar chemical or biologic composition to PLG or known hypersensitivity to GM-CSF, CPG or PLG History of allergic reactions attributed to compounds of similar chemical or biologic composition to prexasertib or LY. History of allergic reactions attributed to compounds of similar chemical or biologic composition to MCS, dabrafenib, or trametinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to ipilimumab or nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to BVD- History of allergic reactions attributed to compounds, or any of its excipients, of similar chemical or biologic composition to osimertinib or selumetinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to abemaciclib History of allergic reactions attributed to compounds of similar chemical or biologic composition to daratumumab Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab Women with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to Tamoxifen. History of allergic reactions attributed to compounds of similar chemical or biologic composition to cyclophosphamide (only for arm B) History of allergic reactions attributed to compounds of similar chemical composition to SY- History of allergic reactions attributed to compounds of similar chemical or biologic composition to gefitinib or osimertinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to LY, vemurafenib, or cobimetinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to apalutamide or docetaxel History of allergic reactions attributed to compounds of similar chemical or biologic composition to prexasertib or olaparib History of allergic reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to cabozantinib (XL) History of allergic reactions attributed to compounds of similar chemical or biologic composition to M (VX-) or gemcitabine History of allergic reactions attributed to compounds of similar chemical or biologic composition to AT (onalespib) History of allergic reactions attributed to compounds of similar chemical or biologic composition to vemurafenib History of allergic reactions attributed to compounds of similar chemical or biologic composition to gemcitabine or IMGN History of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib or venetoclax Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to HMAs History of allergic reactions attributed to compounds of similar chemical or biologic composition to merestinib Participant has a history of allergic reactions attributed to compounds of similar chemical or biologic composition to ACTOplus Met XR History of allergic reactions attributed to compounds of similar chemical or biologic composition to ixazomib or lenalidomide Participant with a history of allergic reactions attributed to compounds of similar chemical or biologic composition of retinoids History of allergic reactions attributed to compounds of similar chemical or biologic composition to prexasertib. Patients who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to bevacizumab are not eligible Subject has a history of allergic reactions attributed to compounds of similar chemical or biologic composition to PROSTVAC or ipilimumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to sertraline History of allergic reactions attributed to compounds of similar chemical or biologic composition to sunitinib or everolimus History of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide History of allergic reactions attributed to compounds of similar chemical or biologic composition to TRC or TMZ History of allergic reactions attributed to compounds of similar chemical or biologic composition to gemcitabine or docetaxel History of severe allergic reactions attributed to compounds of similar chemical or biologic composition to bevacizumab, anetumab ravtansine or paclitaxel History of allergic reactions attributed to compounds of similar chemical or biologic composition to MTX or gadolinium. History of allergic reactions or hypersensitivity attributed to compounds of similar chemical or biologic composition to olaparib or its excipients History of allergic reactions attributed to compounds of similar chemical or biologic composition to any in the regimen Hypersensitivity to chemotherapy or history of allergic reactions attributed to compounds of similar chemical or biologic composition to rituximab, ibrutinib, ICE, Ave, or Uto History of allergic reactions attributed to compounds of similar chemical or biologic composition to ONC or its excipients. History of allergic reactions attributed to compounds of similar chemical or biologic composition to apatinib or pembrolizumab A history of allergic reactions attributed to compounds of similar chemical or biologic composition to palbociclib, cisplatin (for cohort ), or cetuximab (for cohort ) History of allergic reactions attributed to compounds of similar chemical or biologic composition to any of the agents on this trial History of allergic reactions attributed to compounds of similar chemical or biologic composition to cediranib or olaparib History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN (TAK-) History of allergic reactions attributed to compounds of similar chemical or biologic composition to the study agent or accompanying supportive medications. The patient has a history of allergic reactions attributed to compounds of chemical or biologic composition similar to those of cetuximab and/or nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to poxviral vaccines (e.g., vaccinia vaccine) History of allergic reactions attributed to compounds of similar chemical or biologic composition to ONC or its excipients History of allergic reactions attributed to compounds of similar chemical or biologic composition to EGF or gefitinib Subjects with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to IACS-. History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab or mifepristone Patients with a known history of allergic reactions attributed to compounds of similar chemical or biologic composition to cabozantinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide or T-DM History of allergic reactions attributed to compounds of similar chemical or biologic composition to paclitaxel or carboplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to topotecan, other topoisomerase inhibitors or gadolinium compounds Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to HMAs History of allergic reactions attributed to compounds of similar chemical or biologic composition to lamivudine History of allergic reactions attributed to compounds of similar chemical or biologic composition to zydelig History of allergic reactions attributed to compounds of similar chemical or biological composition to cetuximab (anti-EGFR). History of allergic reactions attributed to compounds of similar chemical or biologic composition to anetumab ravtansine or MK- (pembrolizumab) Patients who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide are not eligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to mistletoe History of allergic reactions attributed to compounds of similar chemical or biologic composition to clarithromycin or taxanes History of allergic reactions attributed to compounds of similar chemical or biologic composition to CDX- (varlilumab) and/or nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to HCQ History of allergic reactions attributed to compounds of chemical or biologic composition similar to palbociclib History of allergic reactions attributed to compounds of similar chemical or biologic composition to cabozantinib or nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to olaparib or abiraterone History of allergic reactions attributed to compounds of similar chemical or biologic composition to TRC or pemetrexed and cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to cediranib or olaparib History of allergic reactions attributed to compounds of similar chemical or biologic composition to hydroxychloroquine or received HCQ in the past six months History of allergic reactions attributed to compounds of similar chemical or biologic composition to fosbretabulin History of allergic reactions attributed to compounds of similar chemical or biologic composition to pevonedistat or decitabine History of allergic reactions attributed to compounds of similar chemical or biologic composition to IL- History of allergic reactions attributed to compounds of similar chemical or biologic composition to cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to TVB- History of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide and/or TG History of allergic reactions attributed to compounds of similar chemical or biologic composition to enzalutamide or indomethacin History of allergic reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab, cisplatin, carboplatin, or etoposide History of allergic reactions attributed to compounds of similar chemical or biologic composition to ruxolitinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to daunorubicin History of allergic reactions attributed to compounds of similar chemical or biologic composition to palbociclib, carboplatin or cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to durvalumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to decitabine or talazoparib History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab including any history of severe allergic reactions to monoclonal antibody therapy History of allergic reactions attributed to compounds of similar chemical or biologic composition to cisplatin and pemetrexed History of allergic reactions attributed to compounds of similar chemical or biologic composition to selinexor History of allergic reactions attributed to compounds of similar chemical or biologic composition to blinatumomab Patients who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab are not eligible AND/OR patients who have had prior exposure to compounds of similar chemical or biologic composition to pembrolizumab are not eligible Patients who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to BCG are not eligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to abiraterone or PDMX/niclosamide Patients who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to MEDI are not eligible History of severe allergic reactions attributed to compounds of similar chemical or biologic composition to lenvatinib and/or paclitaxel Known hypersensitivity or history of allergic reactions attributed to compounds of similar chemical or biologic composition to IRX History of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib and brentuximab vedotin (BV) History of allergic reactions attributed to compounds of similar chemical or biologic composition to ramucirumab or nab-paclitaxel History of allergic reactions attributed to compounds of similar chemical or biologic composition to dasatinib A history of allergic reactions attributed to compounds of similar chemical or biologic composition to erlotinib, temozolomide, or dacarbazine History of allergic reactions attributed to compounds of similar chemical or biologic composition to capecitabine or bevacizumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to poxviral vaccines (e.g., vaccinia vaccine) History of allergic reactions attributed to compounds of similar chemical or biologic composition to nab-paclitaxel History of allergic reactions attributed to compounds of similar chemical or biologic composition to ruxolitinib or bortezomib History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab, paclitaxel or carboplatin Subjects with a known history of allergic reactions attributed to compounds of similar chemical or biologic composition to DSb History of allergic reactions attributed to compounds of similar chemical or biologic composition to methoxyamine or to pemetrexed or cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to cabozantinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to study drugs History of allergic reactions attributed to compounds of similar chemical or biologic composition to MEDI- or history of anaphylaxis to any biological component History of allergic reactions attributed to compounds of similar chemical or biologic composition to leflunomide or cholestyramine History of allergic reactions attributed to compounds of similar chemical or biologic composition to talimogene laherparepvec History of allergic reactions attributed to compounds of similar chemical or biologic composition to any in the pre- or post-transplant regimen History of allergic reactions attributed to compounds of similar chemical or biologic composition to cediranib or olaparib History of allergic reactions attributed to compounds of similar chemical or biologic composition to pemetrexed Patients with history of allergic reactions attributed to compounds of similar chemical; or biologic composition to vorinostat or temsirolimus are not eligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to IPdR Prior allergic reactions attributed to compounds of similar chemical or biologic composition to dabrafenib or trametinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide History of allergic reactions attributed to compounds of similar chemical or biologic composition to basiliximab History of allergic reactions attributed to compounds of similar chemical or biologic composition to enzalutamide or metformin History of allergic reactions attributed to compounds of similar chemical or biologic composition to GDC- History of allergic reactions attributed to compounds of similar chemical or biologic composition to VOR or HCQ History of allergic reactions attributed to compounds of similar chemical or biologic composition to ponatinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to ONC or its excipients History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN (TAK-) or ziv-aflibercept A history of allergic reactions attributed to compounds of similar chemical or biologic composition to docetaxel or carboplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to etoposide History of allergic reactions attributed to compounds of similar biologic composition to M or to IL- History of allergic reactions attributed to compounds of similar chemical or biologic composition to propranolol History of prior allergic reactions attributed to compounds of similar chemical or biologic composition as capecitabine History of allergic reactions attributed to compounds of similar chemical or biologic composition to melphalan History of allergic reactions attributed to compounds of similar chemical or biologic composition to DOPC, Magnevist, or fluorodeoxyglucose (FDG) History of allergic reactions attributed to compounds of similar chemical or biologic composition to cisplatin for patients who will receive chemotherapy History of allergic reactions attributed to compounds of similar chemical or biologic composition to IPdR History of allergic reactions attributed to compounds of similar chemical or biologic composition to metformin EXCLUSION CRITERIA FOR REGISTRATION: history of allergic reactions attributed to compounds of similar chemical or biologic composition to metformin History of allergic reactions attributed to compounds of similar chemical or biological composition to Valproic Acid History of allergic reactions attributed to compounds of similar chemical or biologic composition to TCN-PM History of allergic reactions to compounds of similar chemical or biologic composition to talactoferrin or the chemotherapy drugs History of allergic reactions attributed to compounds of similar chemical composition to IHL- History of allergic reactions attributed to compounds of similar chemical or biologic composition to cenersen. History of allergic reactions attributed to compounds of similar chemical or biologic composition to copanlisib and/or nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to CPI- or docetaxel History of allergic reactions attributed to compounds of similar chemical or biologic composition to tamoxifen History of allergic reactions attributed to compounds of similar chemical or biologic composition to -fluorouracil or imiquimod History of allergic reactions attributed to compounds of similar chemical or biologic composition to CPI- History of allergic reactions attributed to compounds of similar chemical or biologic composition; History of allergic reactions attributed to compounds of similar chemical or biologic composition to study drugs History of allergic reactions attributed to compounds of similar chemical or biologic composition to study drugs; patients who have previously received either clofarabine or bortezomib will be excluded History of allergic reactions attributed to compounds of similar chemical or biologic composition to lenvatinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to durvalumab or any excipient or any egg products History of allergic reactions attributed to compounds of similar chemical or biologic composition to enzalutamide or PDMX/niclosamide Participants who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to birinapant or its constituents History of allergic reactions attributed to compounds of similar chemical or biologic composition to WP History of allergic reactions attributed to compounds of similar chemical or biologic composition to M (VX), cisplatin, or gemcitabine History of allergic reactions attributed to compounds of similar chemical or biologic composition to navitoclax or sorafenib Patients with a history of hypersensitivity or allergic reactions attributed to compounds of similar chemical or biologic composition to AMG are ineligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to nelfinavir History of allergic reactions attributed to compounds of similar chemical or biologic composition to abemaciclib History of allergic reactions attributed to compounds of similar chemical or biologic composition to measles virus vaccination History of allergic reactions attributed to compounds of similar chemical or biologic composition to XL Subjects with history of allergic reactions attributed to compounds of similar chemical or biologic composition to AMG or carfilzomib, lenalidomide, or dexamethasone Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to BAL are ineligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to quinacrine, capecitabine or fluorouracil History of allergic reactions attributed to compounds of similar chemical or biologic composition to navitoclax or vistusertib History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to tazemetostat History of allergic reactions attributed to compounds of similar chemical or biologic composition to TAS- or TMZ History of allergic reactions attributed to compounds of similar chemical or biologic composition to olaparib, cediranib, carboplatin, cisplatin, or etoposide History of allergic reactions attributed to compounds of similar chemical or biologic composition to veliparib and MM-; if patients have a history of allergic reactions to compounds resembling MM-, they will be excluded from participating in the FMX MRI study, if applicable History of allergic reactions attributed to compounds of similar chemical or biologic composition to VX-, carboplatin, gemcitabine or to these specific compounds History of allergic reactions attributed to compounds of similar chemical or biologic composition to triapine or cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to MK- and ziv-aflibercept History of allergic reactions attributed to compounds of similar chemical or biologic composition to briciclib History of allergic reactions attributed to compounds of similar chemical or biologic composition to ruxolitinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to study drugs (e.g. cisplatin, paclitaxel) History of allergic reactions attributed to compounds of similar chemical or biologic composition to carfilzomib or belinostat History of allergic reactions to compounds with similar biologic or chemical composition to pembrolizumab or radium- History of allergic reactions attributed to compounds of similar chemical or biologic composition to CYT History of allergic reactions or hypersensitivity attributed to compounds of similar chemical or biologic composition to metformin, ritonavir or any of their ingredients Have history of allergic reactions attributed to compounds of similar chemical or biologic composition to taxanes (docetaxel or paclitaxel) or cyclophosphamide History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to Dex or Enza History of allergic reactions attributed to compounds of similar chemical or biologic composition to either -FU/capecitabine or interferon History of allergic reactions attributed to compounds of similar chemical or biologic composition to TPI History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN or bevacizumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to gemcitabine, nab-paclitaxel or enzalutamide History of allergic reactions attributed to compounds of similar chemical or biologic composition to INCB, MELITAC ., or other vaccine components History of allergic reactions attributed to compounds of similar chemical or biologic composition to cetuximab or ipilimumab Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to sorafenib, bortezomib or decitabine that are not easily managed History of allergic reactions attributed to compounds of similar chemical or biologic composition to PF- No history of allergic reactions attributed to compounds of similar chemical or biologic composition to cabozantinib, temozolomide and dacarbazine History of allergic reactions attributed to compounds of similar chemical or biologic composition to vorinostat History of allergic reactions attributed to compounds of similar chemical or biologic composition to digoxin History of allergic reactions attributed to compounds of similar chemical or biologic composition to dasatinib, erlotinib or gemcitabine History of allergic reactions attributed to compounds of similar chemical or biologic composition of decitabine, cytarabine or daunorubicin History of allergic reactions attributed to compounds of similar chemical or biologic composition to lenalidomide (i.e. thalidomide) Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to afatinib and/or cetuximab History of allergic reactions attributed to compounds of similar chemical composition to afatinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to pazopanib Patient must have no history of allergic reactions attributed to compounds of similar chemical or biologic composition to pazopanib History of allergic reactions attributed to compounds of similar chemical or biologic composition to MK- (pembrolizumab) History of allergic reactions attributed to compounds of similar chemical or biologic composition to VX- History of allergic reactions attributed to compounds of similar chemical or biologic composition to M (VX-) or cisplatin History of Grade or allergic reactions attributed to compounds of similar chemical or biologic composition as MSCA History of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to metformin or rapamycin History of allergic reactions attributed to compounds of similar chemical or biologic composition to mitomycin-C or -fluorouracil History of allergic reactions attributed to compounds of similar chemical or biologic composition to vorinostat or HCQ History of allergic reactions attributed to compounds of similar chemical or biologic composition to daunorubicin or cytarabine History of allergic reactions attributed to compounds or similar chemical or biological composition to ibrutinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to mocetinostat or brentuximab vedotin Patients with history of allergic reactions attributed to compounds of similar chemical or biologic composition to decitabine that are not easily managed History of allergic reactions attributed to compounds of similar chemical or biologic composition to hydroxychloroquine History of allergic reactions attributed to compounds of similar chemical or biologic composition to dacomitinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to dasatinib or any of the components of the vaccine being administered as part of this study History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN, bortezomib or rituximab History of allergic reactions attributed to compounds of similar chemical or biologic composition to AMG or decitabine Patients who have a history of allergic reactions or hypersensitivity reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab and/or humanized antibodies are not eligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to bevacizumab or atezolizumab History of severe allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab or lenalidomide Patients with a history of allergic reactions attributed to bevacizumab or to compounds of similar chemical or biologic composition to nivolumab or bevacizumab are excluded Patients who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab are not eligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to poxviral vaccines (e.g., vaccinia vaccine) History of allergic reactions attributed to compounds of similar chemical or biologic composition to MGE History of allergic reactions attributed to compounds of similar chemical or biologic composition to palbociclib and/or bazedoxifene History of allergic reactions attributed to compounds of similar chemical or biologic composition to PM or trabectedin (Yondelis, ET-) History of allergic reactions attributed to compounds of similar chemical or biologic composition to ONC or its excipients Participants may not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to cediranib or olaparib History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab Patient has a history of allergic reactions attributed to compounds of similar chemical or biologic composition to PBI- (i.e., cardiac glycoside compounds). History of severe allergic reactions attributed to compounds of similar chemical or biologic composition to IL- History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to elotuzumab or lenalidomide Patient has a history of allergic reactions attributed to compounds of similar chemical or biologic composition to MK- Prior treatment with or allergic reactions attributed to compounds of similar chemical or biologic composition to ponatinib Patients must not have a known history of allergic reactions attributed to compounds of similar chemical or biologic composition to perifosine or temsirolimus Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to temsirolimus or perifosine History of allergic reactions attributed to compounds of similar chemical or biologic composition to crizotinib or enzalutamide History of allergic reactions attributed to compounds of similar chemical or biologic composition to gemcitabine and eribulin History of allergic reactions attributed to compounds of similar chemical or biologic composition to X-, docetaxel, or granulocyte colony stimulating factors History of severe allergic reactions attributed to compounds of similar chemical or biologic composition to ofatumumab or idelalisib History of allergic reactions attributed to compounds of similar chemical or biologic composition to carboplatin or docetaxel Patients with history of allergic reactions attributed to compounds of similar chemical or biologic composition to decitabine that are not easily managed Research participants with a history of allergic reactions attributed to compounds of similar chemical or biological composition to cetuximab PHASE I: History of allergic reactions attributed to compounds of similar chemical or biologic composition to ruxolitinib PHASE II: History of allergic reactions attributed to compounds of similar chemical or biologic composition to ruxolitinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to palbociclib History of allergic reactions attributed to compounds of similar chemical or biologic composition to cabozantinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to entinostat, azacitidine, or nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to rucaparib. Participants who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to neratinib or fulvestrant History of allergic reactions attributed to lenalidomide or compounds of similar chemical or biologic composition to lenalidomide including thalidomide PART B: History of allergic or severe reactions attributed to compounds of similar chemical or biologic composition to ponatinib History of grade or allergic reactions attributed to compounds of similar chemical or biologic composition to ARRY- or trastuzumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib or lenalidomide History of allergic reactions attributed to compounds of similar chemical or biologic composition to tivozanib or enzalutamide History of allergic reactions attributed to compounds of similar chemical or biologic composition to enzalutamide or poxviral vaccines (e.g., vaccinia vaccine) History of allergic reactions attributed to compounds of similar chemical or biologic composition to enzalutamide or poxviral vaccines (e.g., vaccinia vaccine) History of allergic reactions attributed to compounds of similar chemical or biologic composition to AUY History of allergic reactions attributed to compounds of similar chemical or biologic composition to midostaurin and/or decitabine History of allergic reactions attributed to compounds of similar chemical or biologic composition to sunitinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to capecitabine Patients must NOT have history of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide or capecitabine History of allergic reactions attributed to, or intolerance of, or other significant toxicity with, compounds of similar chemical or biologic composition to X- or everolimus REGISTRATION EXCLUSION CRITERIA: History of allergic reactions attributed to compounds of similar chemical or biologic composition to trastuzumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to bevacizumab History of allergic reactions attributed to compounds of similar chemical or biological composition as ARQ History of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide History of allergic reactions attributed to compounds of similar chemical or biologic composition to lenalidomide (including thalidomide), clarithromycin, or melphalan History of allergic reactions attributed to compounds of similar chemical or biologic composition to FLT History of allergic reactions attributed to compounds of similar chemical or biologic composition to dexanabinol History of allergic reactions attributed to compounds of similar chemical or biologic composition to black cohosh History of allergic reactions attributed to compounds of similar chemical or biologic composition to sunitinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to vorinostat History of allergic reactions attributed to compounds of similar chemical or biologic composition to sorafenib History of allergic reactions attributed to compounds of similar chemical or biologic composition to ABT- or abiraterone History of allergic reactions attributed to compounds of similar chemical or biologic composition to fulvestrant or ganetespib History of allergic reactions attributed to compounds of similar chemical or biologic composition to neratinib (or to capecitabine for cohorts a/b) History of allergic reactions attributed to compounds of similar chemical or biologic composition to capecitabine and hydroxychloroquine (HCQ) History of allergic reactions attributed to compounds of similar chemical or biologic composition to plerixafor or bevacizumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to AMG History of allergic reactions to palbociclib or attributed to compounds of similar chemical or biologic composition to palbociclib History of allergic reactions attributed to compounds of similar chemical or biologic composition to cediranib maleate or olaparib History of allergic reactions attributed to compounds of similar chemical or biologic composition to PF- History of allergic reactions attributed to compounds of similar chemical or biologic composition to BMN (talazoparib) History of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib or idarubicin or cytarabine Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to platinums, taxanes or fluoropyrimidines Prior allergic reactions attributed to compounds of similar chemical or biologic composition to gemcitabine (gemcitabine hydrochloride) or cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to MK- or cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to erlotinib or clindamycin (topical agent for potential skin toxicity) History of allergic reactions attributed to compounds of similar chemical or biologic composition to erlotinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to MEK, anthracycline, or cytarabine History of allergic reactions attributed to compounds of similar chemical or biologic composition to lapatinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to peg-IFN?-b History of allergic reactions attributed to compounds of similar chemical or biologic composition to SS(dsFv)PE History of allergic reactions attributed to compounds of similar chemical or biologic composition to MPDLA, carboplatin, or paclitaxel Patient with history of allergic reactions or hypersensitivity attributed to compounds of similar chemical or biologic composition to enzalutamide, carboplatin, or paclitaxel History of allergic reactions attributed to compounds of similar chemical or biologic composition to palbociclib History of allergic reactions attributed to compounds of similar chemical or biologic composition to erlotinib and/or onalespib History of allergic reactions attributed to compounds of similar chemical or biologic composition to onalespib or ATM History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN (TAK-) History of allergic reactions attributed to compounds of similar chemical or biologic composition to vorinostat or temsirolimus Patients with history of allergic reactions attributed to compounds of similar chemical or biologic composition to belinostat, including hydroxamate compounds or arginine History of allergic reactions attributed to compounds of similar chemical or biologic composition to lithium carbonate History of allergic reactions attributed to compounds of similar chemical or biologic composition to dinaciclib or to MK- History of allergic reactions attributed to compounds of similar chemical or biologic composition to carboplatin, or nab-paclitaxel History of allergic reactions attributed to compounds of similar chemical or biologic composition to gemcitabine (gemcitabine hydrochloride) or cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to MK- History of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib or R-ICE History of allergic reactions attributed to compounds of similar chemical or biologic composition to tivozanib History of allergic reactions attributed to compounds of similar chemical or biologic composition to MK- Known hypersensitivity/history of allergic reactions attributed to compounds of similar chemical or biologic composition to everolimus or fulvestrant. Known hypersensitivity to ipilimumab or history of allergic reactions attributed to compounds of similar chemical or biologic composition to ipilimumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to Cabazitaxel, or to drugs formulated with polysorbate . History of allergic reactions attributed to compounds of similar chemical or biologic composition to rituximab History of allergic reactions attributed to compounds of similar chemical or biologic composition as TG citrate. History of allergic reactions attributed to compounds of similar chemical or biologic composition to pioglitazone History of allergic reactions attributed to compounds of similar chemical or biologic composition to dasatinib and ipilimumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to dabrafenib and its excipients. History of allergic reactions attributed to compounds of similar chemical or biologic composition to panitumumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to ARQ or temsirolimus History of allergic reactions attributed to compounds of similar chemical or biologic composition to vemurafenib or leflunomide History of allergic reactions attributed to compounds of similar chemical or biologic composition to erlotinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN, including but not limited to established allergic reaction to benzodiazepines History of allergic reactions attributed to compounds of similar chemical or biologic composition to RAD or SOM (pasireotide) History of allergic reactions attributed to compounds of similar chemical or biologic composition to sorafenib or hydroxychloroquine The participant has a history of allergic reactions attributed to compounds of chemical or biologic composition similar to that of cixutumumab or to octreotide History of allergic reactions attributed to compounds of similar chemical or biologic composition to talimogene laherparepvec Patients who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to volasertib or VSLI are not eligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to talazoparib History of allergic reactions attributed to compounds of similar chemical or biologic composition to bevacizumab, nab-paclitaxel or temozolomide Patients must not have a known history of allergic reactions attributed to compounds of similar chemical or biologic composition History of allergic reactions attributed to compounds of similar chemical or biologic composition to eribulin mesylate or pembrolizumab History of allergic reactions attributed to tamoxifen or compounds of similar chemical or biologic composition History of allergic reactions attributed to compounds of similar chemical or biologic composition to CUDC- History of allergic reactions attributed to compounds of similar chemical or biologic composition to apalutamide, abiraterone acetate, or other study drugs History of severe (i.e. anaphylactic) allergic reactions attributed to compounds of similar chemical or biologic composition to glucocorticoids and other component of R- History of allergic reactions attributed to compounds of similar chemical or biologic composition to cadaveric component, i.e. Flex HD History of allergic reactions attributed to compounds of similar chemical or biologic composition to Adriamycin, dacarbazine, or brentuximab History of allergic reactions attributed to compounds of similar chemical or biologic composition to naltrexone No investigational agent, so no exclusion requirements regarding history of allergic reactions attributed to compounds of similar chemical or biologic composition to investigational agent or device Patient must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to lithium carbonate History of allergic reactions attributed to compounds of similar chemical or biologic composition to ruxolitinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to erlotinib History of allergic reactions to yeast or attributed to compounds of similar chemical or biologic composition to Gardasil HPV vaccine History of allergic reactions attributed to compounds of similar chemical or biologic composition to exemestane History of allergic reactions attributed to compounds of similar chemical or biologic composition to erlotinib (Tarceva) History of allergic reactions attributed to compounds of similar chemical or biologic composition to -OHT gel History of adverse effects, intolerance, or allergic reactions attributed to compounds of similar chemical or biologic composition to simvastatin (i.e., other statin medications) History of allergic reactions attributed to compounds of similar chemical or biologic composition to NeuVax History of allergic reaction to zileuton or attributed to compounds of similar chemical or biologic composition to zileuton History of allergic reactions attributed to compounds of similar chemical or biologic composition to MUC/Poly?ICLC History of adverse effects, intolerance, or allergic reactions attributed to compounds of similar chemical or biologic composition to simvastatin (i.e., other statin medications) History of allergic reactions attributed to compounds of similar chemical or biologic composition to WOKVAC History of allergic reactions attributed to compounds of similar chemical or biologic composition to Avmacol History of allergic reactions attributed to compounds of similar chemical or biologic composition to bexarotene gel, oral or topical retinoids History of allergic reactions or intolerance attributed to aspirin or compounds of similar chemical or biologic composition History of allergic reactions attributed to compounds of similar chemical or biologic composition to green tea or EGCG History of allergic reactions attributed to compounds of similar chemical or biologic composition to Meriva Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition of alendronate and other bisphosphonates Documented history of allergic reactions attributed to compounds of similar chemical or biologic composition to buproprion History of allergic reactions attributed to compounds of similar chemical or biologic composition to aspirin Participants must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition of iloprost History of adverse effects, intolerance, or allergic reactions attributed to compounds of similar chemical or biologic composition to pravastatin (i.e., other statin medications) History of allergic reactions attributed to compounds of similar chemical or biologic composition of PROSTVAC Participants with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to berberine will be excluded History of allergic reactions attributed to compounds of similar chemical or biologic composition to telapristone (i.e. other progesterone antagonists) History of allergic reactions attributed to compounds of similar chemical or biologic composition to PFE A history of allergic reactions attributed to compounds of similar chemical or biologic composition to tamoxifen History of allergic reactions attributed to compounds of similar chemical composition to YF History of allergic reactions attributed to aspirin or compounds of similar chemical or biologic composition to the study agent History of allergic reactions attributed to compounds of similar chemical or biologic composition to the study agent Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN (TAK-) are ineligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to romidepsin, including cyclic tetrapeptide compounds History of allergic reactions attributed to compounds of similar chemical or biologic composition to linaclotide Participants with a history of allergic reactions attributed to compounds of similar chemical or biologic composition of retinoids History of allergic reactions attributed to compounds of similar chemical or biologic composition to PBR History of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide or FMISO History of allergic reactions attributed to compounds of similar chemical or biologic composition to demeclocycline SURGICAL ARM: history of allergic reactions attributed to compounds of similar chemical or biologic composition to tetracyclines History of allergic reactions attributed to compounds of similar chemical or biologic composition to ferumoxytol History of allergic reactions attributed to compounds of similar chemical or biologic composition to magnetic resonance (MR) contrast material History of allergic reactions attributed to compounds of similar chemical or biologic composition to FDHT History of allergic reactions attributed to compounds of similar chemical or biologic composition to L-[methyl-C]methionine History of allergic reactions attributed to compounds of similar chemical or biologic composition to lorlatinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to aminolevulinic acid (ALA) History of allergic reactions attributed to compounds of similar chemical or biologic composition to Eovist History of allergic reactions attributed to compounds of similar chemical or biologic composition to vitamin D History of allergic reactions attributed to compounds of similar chemical or biologic composition to idelalisib The participant has a history of allergic reactions attributed to compounds of chemical or biologic composition similar to those of cetuximab or cisplatin. The participant has a history of allergic reactions attributed to compounds of chemical or biologic composition similar to those of cetuximab or carboplatin. History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab, ipilimumab, or blinatumomab History of allergic reactions attributed to compounds of similar chemical or biologic composition to cetuximab.