Known contraindication to receive cetuximab or irinotecan at the planned doses No contraindication for surgery Any medical or physical contraindication, or other inability to undergo hematopoietic progenitor cell (HPC) collection Surgery, unless documented contraindication Radiotherapy, unless documented contraindication Chemotherapy, unless documented contraindication Contraindication to angiography or chemoembolization medications Known contraindication to phosphodiesterase- inhibitors (e.g. currently on nitrates) Any known factors that would pose a contraindication to receiving nivolumab History of documented anaphylaxis or contraindication to any of the study medications All patients with tumors involving the thoracic esophagus must undergo bronchoscopy to document the absence of a fistula no known contraindication to the use of taxanes or platinum compounds Contraindication to angiography/embolization procedure based on judgment of the treating investigator Contraindication to MRI Participant has a contraindication to biopsy Medical contraindication to receipt of radiotherapy No contraindication to tumor biopsy at time of study enrollment Contraindication to any concomitant medication, including antivirals, anticoagulation prophylaxis, tumor lysis prophylaxis, or hydration given prior to therapy Contraindication to RPFNA including breast implant(s), bilateral radiation, anticoagulation (excluding those on mg aspirin) Contraindication to receiving radiotherapy Known contraindication for topotecan or temozolomide Contraindication to cyclophosphamide or fludarabine chemotherapy Extensive loculations or hydropneumothorax or other contraindication to pleurodesis Contraindication or precaution for enzalutamide Any condition that would be a contraindication to receiving trastuzumab as described in the approved local label or a condition that would prevent treatment with the physician's choice of chemotherapy Contraindication to receive radiotherapy Contraindication to IV contrast Contraindication to cyclophosphamide or fludarabine chemotherapy Patients with contraindication to thromboprophylaxis Any contraindication to therapy with nivolumab Medical contraindication to radiation treatment (e.g. active systemic sclerosis, other uncontrolled autoimmune condition) CRITERIA FOR SCREENING: Any known and irreversible contraindication to huJCAR therapy Contraindication to the use of PTX Has a history or current evidence of physical or physiological contraindication to participation in this study, at the discretion of the treating investigator Patients with any contraindication to receiving rhuGM-CSF based products Absence of contraindication for Ommaya reservoir Any contraindication to the combination anti-cancer agent as per local prescribing information Contraindication to any of the individual components of CHOP, including prior receipt of anthracyclines Active uncontrolled infection that would be a contraindication to safe use of high-dose therapy Contraindication to any concomitant medication, including pre-medications or hydration given prior to therapy No contraindication to be on a minimum of mg aspirin a day (or other anticoagulant therapy as prescribed) for thromboembolism prophylaxis Have a contraindication to post-ASCT maintenance lenalidomide Patients who have contraindication to cyclophosphamide chemotherapy Contraindication for undergoing MRIs Subjects with a contraindication to MR-HIFU. Medical contraindication to the use of varenicline OR nicotine patch Medical contraindication to the use of bupropion Patients with documented contraindication to anticoagulation therapy such as heparin induced thrombocytopenia or a documented coagulopathy or hematologic disorder that would contraindicated undergoing treatment and use of the associated anticoagulant agents required during treatment Patients with any contraindication to receiving rhuGM-CSF based products Contraindication to receiving HCQ or TACE Contraindication to or unwillingness to undergo study related procedures including a repeat bronchoscopy Contraindication or unwillingness to undergo multiple CT scans Contraindication to receiving radiotherapy or TACE Presenting with a general or visceral contraindication to intensive treatment including: Patient has a known hypersensitivity or contraindication to study products that, in the opinion of the investigator, cannot be adequately pre-medicated Patient with contraindication for imaging with MRI HAPLOIDENTICAL RELATED DONOR: History of other medical conditions that in the opinion of PI constitute a contraindication to donation Requires treatment with other medications that cannot be stopped and for which there is a known contraindication to co-administration of one or more of the study drugs. Have known contraindication to Gd-MRI. Medical contraindication to apheresis Contraindication to haploidentical HCT as defined by the Investigator Patients with contraindication for treatment by laparoscopy Known contraindication to aromatase inhibitor or SERM therapy Part : have a major contraindication to MP (e.g., allergy/hypersensitivity to study medications or their constituents), or conditions making adherence difficult as determined by the attending physician Any medical or physical contraindication or any other inability to undergo HSPC collection Any medical or physical contraindication or other inability to undergo HSPC collection Contraindication to cisplatin chemotherapy or plans to alter or reduce cisplatin therapy Known contraindication to MRI, such as cardiac pacemaker, shrapnel or ocular foreign body. Known contraindication to MRI, such as cardiac pacemaker, shrapnel, or ocular foreign body Contraindication to treatment for TE prophylaxis Contraindication to any drug in the chemotherapy regimen, and specifically Any contraindication to oral agents. Known or suspected hypersensitivity to ofatumumab or SB- that in the opinion of the investigator is a contraindication to their participation in the study Contraindication to any concomitant medication, including antivirals, anticoagulation prophylaxis, tumor lysis prophylaxis, or hydration given prior to therapy Contraindication to all available herpes simplex virus (HSV)/varicella prophylactic antiviral drugs Patients who have contraindication to MRI Absolute contraindication for MRI imaging such as intracorporeal metal or pacemaker Any contraindication to ECP, i.e. contraindication to heparin or methoxsalen (-MOP) Clear contraindication for systemic corticosteroids (diabetes mellitus is not per se a clear contraindication); Patients with contraindication to thromboprophylaxis Contraindication to MRI Participants with contraindication to RT while adjuvant RT is clinically indicated Contraindication to any concomitant medication, including antivirals or anticoagulation Contraindication to any concomitant medication, including antivirals, anticoagulation prophylaxis, tumor lysis prophylaxis, or hydration given prior to therapy. Contraindication to any concomitant medication, including antivirals or anticoagulation Contraindication to heparin as per NCCN guidelines Contraindication to corticosteroids Contraindication to EUS-guided needle puncture into the pancreas Patients with contraindication to steroid use Contraindication to chemotherapy or radiation Contraindication to any concomitant medication, including antivirals or anticoagulation Any contraindication for TACE. Any contraindication for doxorubicin administration: Subjects with an absolute contraindication to corticosteroid administration Previous treatment with fluoropyrimidine-, oxaliplatin- and irinotecan- based chemotherapy, an anti-VEGF therapy (if no contraindication) and if KRAS wild type and no contraindication, an anti-EGFR therapy. Contraindication to propranolol, etodolac Patients with any known contraindication to treatment with, including hypersensitivity to quinacrine or erlotinib Contraindication to concomitant anticoagulation prophylaxis Any other contraindication listed in the local labeling of dalteparin, enoxaparin, or edoxaban; Any contraindication to MRI examination Contraindication to potential treatment agents Known contraindication to dexamethasone Contraindication to any of the required concomitant drugs, including antiviral (e.g. Valacyclovir) Contraindication for all comparators: Patients with contraindication to dexamethasone. Known or suspected hypersensitivity to ofatumumab or bendamustine that in the opinion of the investigator is a contraindication to their participation in the present study. Contraindication for nicotine patch use History of documented anaphylaxis or contraindication to any of the study medications Contraindication or allergy to intravenous lidocaine Subject, as deemed by treating investigator has contraindication to endoscopy or Spray Cryotherapy Procedure. Major contraindication to methylphenidate i.e. hypersensitivity Medical contraindication to exercise Pregnant patients will not be included in the study as pregnancy is a relative contraindication for these types of surgical procedures Major contraindication to ginseng: allergy/hypersensitivity to Panax species or their constituents (history of arrhythmias, agitation, or motor tics, or severe angina pectoris) Contraindication to placement of an IPC (e.g., uncorrected coagulopathy) Known contraindication to receiving G-CSF Allergy or other contraindication to morphine sulfate The allogeneic PBSC donor has a contraindication to statin treatment Participant has allergy or other contraindication for morphine or gabapentin therapy Do not have a contraindication to MRI (i.e., pacemaker) Contraindication for the nicotine patch (e.g., heart attack, angina, skin allergies) unless a doctors note is provided. The allogeneic PBSC donor has a contraindication to statin treatment Medical contraindication to receipt of radiotherapy No known contraindication to NSAID use Patients who have a contraindication to radiation therapy Presence of any contraindication for a neurosurgical procedure contraindication to anticoagulant therapy Has contraindication to MRI contrast Any contraindication to MRI (e.g., pacemaker, aneurysm clip, tissue expander) Contraindication to MRI Contraindication to PET Contraindication to Lasix Contraindication to MRI scan (i.e. due to cardiac pacemaker) Any contraindication to bronchoscopy, for example: Inability or contraindication to undergo transcatheter arterial embolization Known hypersensitivity to glucagon (contraindication for glucagon IV, required for endorectal MRI only) Pheochromocytoma, insulinoma or galactosemia (contraindication for glucagon IV, required for endorectal MRI only) Any contraindication to MRI (e.g., pacemaker, aneurysm clip, tissue expander) Any contraindication to MRI (e.g., pacemaker, aneurysm clip, tissue expander) Any absolute contraindication to MRI (e.g., pacemaker, aneurysm clip, tissue expander) Contraindication to MRI Contraindication to PET Contraindication for MP MRI Contraindication or allergy to Feraheme (based on insert) Contraindication to MRI Contraindication to potassium iodide Contraindication to prostate mpMRI (renal failure, hip prosthesis, pacemaker, etc) Contraindication to use of fluoropyrimidines as a radiosensitizing agent Contraindication to prostate biopsy Claustrophobia or any other contraindication to MRI imaging evaluated by a standardized safety questionnaire Patient who has a contraindication to endoscopy Have no contraindication to short-term atorvastatin therapy History of any condition deemed by the principal investigator to be a contraindication to B-WARM therapy (e.g., skin reaction, dysregulation of thermoregulation, etc) Contraindication to test article, constituents, or required concomitant medications