Known hypersensitivity to any of the study drugs or excipients, e.g., polysorbate and Cremophor EL Hypersensitivity to pembrolizumab or history of severe allergic or hypersensitivity reactions to excipients (e.g., polyethylene glycol [PEG] and polysorbate ) A known history of allergy to docetaxel, Cremophor or polysorbate (Tween ) Polysorbate History of severe hypersensitivity reaction (>= grade ) to docetaxel, polysorbate containing drugs, or any of the capsule components of enzalutamide, including Labrasol, butylated hydroxyanisole, and butylated hydroxytoluene Patients may not have a history of allergic reaction or hypersensitivity to microcrystalline cellulose (Avicel PH) or polysorbate (Tween ), which are components of the drug product MGCD Patients with known allergy to cremophor or polysorbate Patients with hypersensitivity to docetaxel or polysorbate (Arm A only) polysorbate Patients with a history of a hypersensitivity reaction to products containing polysorbate (Tween ) Known hypersensitivity to any study drug component including thapsigargin derivatives, polysorbate , or propylene glycol History of severe hypersensitivity reaction (>= grade ) to polysorbate containing drugs polysorbate E . History of hypersensitivity to docetaxel, or polysorbate . History of hypersensitivity to polysorbate Hypersensitivity to polysorbate History of severe allergic or hypersensitivity reactions to excipients (e.g., polyethylene glycol [PEG] and polysorbate ) Patients with known prior severe hypersensitivity reactions to cabazitaxel or other agents containing polysorbate History of severe hypersensitivity reaction to polysorbate History of severe (grade or ) allergic or hypersensitivity reactions to excipients (e.g., polyethylene glycol [PEG] and polysorbate ) History of severe allergic or hypersensitivity reactions to excipients (e.g., polyethylene glycol [PEG] and polysorbate ) History of hypersensitivity to docetaxel or polysorbate