Candidate for potentially radical, maximal effort cytoreductive surgery at the discretion and expertise of the treating physician The subject is a candidate for surgery or loco-regional treatment with curative intent. Must be a candidate for salvage surgery Not candidate for curative surgery, is unfit for surgery, or does not wish to undergo curative surgery The patient must be a suitable candidate for surgery, in the opinion of the treating physician Appropriate candidate for breast-conserving surgery based on multi-disciplinary assessment Subjects are not a candidate for breast conserving surgery Subject not a candidate for surgery; Candidate for definitive cancer surgery as determined by treating physician Patient is not a candidate for definitive cancer surgery Group : must not be a candidate for radiation therapy or surgery The patient is medically suitable candidate for preoperative chemotherapy and surgery in the judgment of the treating physicians Not currently a candidate for curative treatment Locally advanced lung cancer candidate for curative treatment through radical surgery and/or radio(chemo)therapy Appendiceal adenocarcinoma basket\r\n* Metastatic appendiceal adenocarcinoma\r\n* Not considered candidate for curative surgery Unresectable disease (defined as the participant not being a candidate for curative surgery) The patient must be a suitable candidate for surgery, in the opinion of the treating physician Must be a candidate for surgery and/or radiation therapy A candidate for curative surgery Patients must be a candidate for surgery Appropriate candidate for surgery Candidate for curative surgery or definitive chemoradiation Candidate for curative breast cancer surgery (Cohort or ) Acceptable candidate for laparoscopic/robotic gynecology (GYN) surgery as per discretion of the surgeon Patients with other poorly controlled medical conditions that in the opinion of the surgeon, make them not a candidate for primary cytoreductive surgery Patient not a candidate for surgery (neck dissection) because of an underlying medical condition Candidate for surgery Patients must be considered an appropriate candidate for surgery by a qualified surgeon Criteria , Participant is a candidate for hepatic surgery or local regional therapy of liver metastases with curative intent