[c09aa8]: / clusters / 9knumclustersv2 / clust_214.txt

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Receipt of previous approved or investigative immune modulatory agent within days of receiving the first dose of treatment;
. Receipt of any investigational anti-cancer therapy within weeks prior to first dose of TAB;
Receipt of any conventional or investigational anticancer therapy not otherwise specified within days of the planned first dose.
Prior receipt of any investigational immunotherapy. Subjects may have received agents that have local health authority approval for the disease indication
Grade or higher hypersensitivity reaction to prior receipt of any antibody therapy
Receipt of a therapeutic anticoagulant
Receipt of a stable ART regimen for at least weeks prior to start of trial
Receipt of any type of anticancer antibody (including investigational antibody) within weeks before planned first dose of study drug
Prior corticosteroids as anti-cancer therapy within a minimum of days of first receipt of study drug
PART II: Greater than or equal to week since receipt of standard or investigational HER-directed therapy for metastatic or recurrent disease
Receipt of tranexamic acid or other antifibrinolytics within hrs prior to infusion
Patients receiving any other investigational or commercial agents or therapies administered with the intention to treat their malignancy within days of first receipt of study drug with the exception of: hydroxyurea (HU) in patients who need to continue this agent to maintain WBC count =< ,/mm^
Receipt of an investigational agent within days (or days for an antibody-based therapy) before the first planned dose of study drugs
Prior chemotherapy, radiation (other than short cycle of radiation to reduce bone pain), treatment with a VEGF inhibitor, PARP inhibitor or immunotherapy within days of first receipt of study drug. Hormone therapy within days of first receipt of study drug.
Receipt of Investigational agents within days prior to first dose of protocol therapy.
Receipt of any anti-cancer therapy within days of starting BP, with the exception of hydroxyurea or anagrelide, or TKI (within days)
Less than days between registration and the last receipt of chemotherapy, biotherapy, immunotherapy, radiotherapy (excluding palliative radiotherapy), or major surgery; prior receipt of immunomodulatory therapy (eg: nivolumab) is permitted, as long as there has been a day washout period following the most recent treatment
Receipt of any investigational therapy is not permitted within days prior to the first dose of nivolumab
Receipt of any conventional or investigational anticancer therapy not otherwise specified above within days of half-lives of the agent prior to the first dose of durvalumab and tremelimumab
Receipt of any anti-cancer therapy within days prior to CD, with the exception of hydroxyurea or anagrelide (within hours), TKI (within days), or a single dose of cytarabine (for proliferative disease)
Receipt of any investigational agent or study treatment within days prior to CD
Receipt of therapies or procedures prior to first dose including:
Receipt of any other investigational agents within days prior to study treatment
Receipt of an investigational agent within days (or days for an antibody-based therapy) before the first planned dose of study drugs
Receipt of sunitinib within months of receiving tremelimumab
Subject who received any therapies intended to treat malignancy within days of first receipt of DS-b
Participants receiving any other investigational or commercial agents or therapies administered with the intention to treat their malignancy within days from first receipt of study drug
Receipt of any type of small molecular kinase inhibitor (including investigational kinase inhibitors) within weeks of enrollment or receipt of any anti-cancer therapy (including investigational therapy, monoclonal antibodies, cytokine therapy) within weeks of enrollment
Prior receipt of an indoleamine ,-dioxygenase (IDO) inhibitor
Received any therapies intended to treat malignancy within days of first receipt of DS-b (except for hydroxyurea, which must be discontinued at least hours prior to study treatment).
Receipt of Gliadel therapy
Receipt of any systemic (oral, intravenous, or inhaled) antifungal therapy for this infection episode for or more consecutive days (>= hours) immediately before randomization.
Receipt of posaconazole or voriconazole as empirical treatment for this infection for days ( hours) or more within the days immediately before randomization.
Prior receipt of a PIM inhibitor
Receipt of all standard therapies for the tumor type:
Receipt of any systemic anticancer therapy within days prior to the first dose of MEDI
Requirement of radiotherapy to treat brain metastases or receipt of any non-study systemic therapy for cancer or any other experimental/investigational treatment.
Receipt of any investigational medication within weeks prior to randomization
Prior enrollment in NCI protocol -C- with receipt of at least doses of TARP peptide vaccine (i.e. completion of primary vaccination series)
Prior receipt of cumulative RAI doses in excess of mCi
Prior receipt of an IDO inhibitor.
Prior receipt of a BET inhibitor (Treatment Group B only).
Prior receipt of an LSD inhibitor including INCB (Treatment Group C only).
Receipt of any radiotherapy or hormonal therapy for cancer treatment within days prior to first dose of study treatment
Receipt of any investigational medication within weeks prior to enrollment
Receipt of anticancer therapy:
Receipt of any investigational medication within weeks prior to enrollment
Receipt of an investigational agent within days (or days for an antibody-based therapy) before the first planned dose of study drugs
Receipt of any investigational medication within weeks prior to enrollment
Receipt of any type of small molecular kinase inhibitor (including investigational kinase inhibitors) within weeks or half-lives (whichever is shorter) of enrollment or receipt of any anti-cancer therapy (including investigational therapy, monoclonal antibodies, cytokine therapy) within weeks of enrollment
Receipt of anticancer therapy within days prior to the first dose of Investigational Product
Patients who, in the opinion of the physician, would not be clinically appropriate for receipt of the therapy regimen associated with participation
Receipt of treatment with another investigational device or drug
Receipt of drug that will affect biologic response to radiation (radiosensitizer or radioprotector)
Receipt of any other investigational agents within days prior to study enrollment
Receipt of an investigational agent within days (or days for an antibody-based therapy) before the first planned dose of study drugs
Receipt of an investigational agent within days (or days for an antibody-based therapy) before the first planned dose of study drugs; (immune checkpoint inhibitors that are antibody-based will only require days before enrollment)
Receipt of any other investigational agent within the days prior to Day .
Receipt of another investigational drug within days of enrollment.
Gastrointestinal disease that interferes with receipt of oral drugs;
Receipt of investigational drugs within days before D of alisertib
Receipt of treatment known to potentially affect the course of AA within last month
Receipt of any investigational agents within days before the first dose of ibrutinib
Receipt of corticosteroids > mg/day within weeks prior tost dose
Receipt of any investigational agent within weeks prior to st dose
Participation in a therapeutic research study or receipt of an investigational drug within days of T-cell infusion
Receipt of any conventional or investigational anticancer therapy within days prior to the first dose of MEDI.
Receipt of any investigational treatment within weeks of scheduled dosing day .
Receipt of lapatinib within days of scheduled dosing day .
At least two-weeks since receipt of prior standard or investigational therapy
Receipt of any conventional or investigational anticancer treatment within days prior to the first dose of MEDI.
Receipt of investigational therapy in a clinical trial setting within days of enrollment;
At least days since receipt of chimeric antigen receptor therapy or other modified T cell therapy
Receipt of anticancer therapy:
Receipt of any BRAF inhibitor (in metastatic melanoma), or investigational anticancer therapy within weeks prior to the first dose of MEDI (AMP-)
Receipt of an investigational drug within days prior to initiation of study treatment
Participants receiving any other investigational or commercial agents or therapies administered with the intention to treat their malignancy within days of first receipt of study drug, with the exception of hydroxyurea as defined in protocol
Chemotherapy or any other investigational agents within days of first receipt of study treatment, or major surgery within days of first receipt of study treatment, or palliative radiation within days of first receipt of study treatment
Receipt of an investigational drug within days prior to study start
Receipt of other anticancer therapy within - weeks, depending on the treatment
Receipt of any investigational anticancer therapy within days prior to the first dose of MEDI, or in the case of monoclonal antibodies (eg, bevacizumab), days prior to the first dose of MEDI
Receipt of any type of small molecule kinase inhibitor (including investigational kinase inhibitors) within weeks of enrollment or receipt of any anti-cancer therapy (including investigational therapy, monoclonal antibodies, cytokine therapy) within weeks of enrollment
Receipt of any conventional or investigational anticancer therapy within weeks prior to the first dose of durvalumab and IPH
Prior participation, i.e., receipt of study medication, in this study;
Prior corticosteroids as anti-cancer therapy within a minimum of days of first receipt of study drug
Receipt of intravenous immunoglobulin therapy (IVIG) < days prior to calendar day of vaccination
FOR THE SUBJECTS ENROLLED IN YEAR : Receipt of IVIG < days prior to calendar day of vaccination
Receipt of intravenous immunoglobulin therapy (IVIG) < days prior to vaccination
Receipt of ART for at least days prior to randomization
Receipt of locoregional therapy (LRT) with verification of complete response at least days following treatment
Receipt of any investigational agents within days prior to commencing study treatment
Receipt of an investigational drug or device within days of enrollment.