Current uncontrolled hypertension (systolic blood pressure [BP] >  mmHg or diastolic pressure >  mmHg despite optimal medical management) as well as prior history of hypertensive crisis or hypertensive encephalopathy.
Uncontrolled chronic hypertension defined as systolic >  or diastolic >  despite optimal therapy.
Uncontrolled hypertension (as defined as ? / despite optimal medical management)
Uncontrolled arterial hypertension >/= / >/=  millimeter of mercury (mmHg) despite standard medical management;
Current uncontrolled hypertension (systolic blood pressure [BP] >  mmHg or diastolic pressure >  mmHg despite optimal medical management) as well as prior history of hypertensive crisis or hypertensive encephalopathy.
Uncontrolled hypertension despite optimal medical management
Hypertension not controlled by medical therapy (resting systolic blood pressure greater than  mmHg or diastolic blood pressure greater than  mmHg on at least two occasions over a  hour period despite optimal medical management)
Evidence of poorly controlled hypertension which is defined as systolic blood pressure >  mmHg or diastolic pressure >  mmHg despite optimal medical management
Poorly controlled hypertension, defined as sustained, uncontrolled, non-episodic baseline hypertension consistently above / mmHg despite optimal medical management
Severe and uncontrolled Cushing syndrome despite medical management (e.g., systolic blood pressure >  mmHg or hyperglycemia with fasting glucose above  mg/dL).
Sustained uncontrolled hypertension (> / average over  week) despite optimal medical management
FOR ALL PHASES (Ib AND II): Uncontrolled arterial hypertension despite optimal medical management
Uncontrolled hypertension (systolic pressure >  mmHg or diastolic pressure >  mmHg on repeated measurement) despite optimal medical management
Clinically significant uncontrolled hypertension (systolic blood pressure >  mmHg or diastolic pressure >  mmHg despite optimal medical management)
Uncontrolled hypertension defined as systolic blood pressure >  mmHg or diastolic pressure >  mmHg, despite optimal medical management
Uncontrolled hypertension (blood pressure >= / mmHg despite optimal medical management)
Uncontrolled hypertension despite optimal medical management (per investigators assessment)
CAPMATINIB EXCLUSION CRITERIA: Cardiovascular disorders including:\r\n* Symptomatic congestive heart failure (New York Heart Association class III or IV)\r\n* Personal or family history of congenital long QT syndrome\r\n* Corrected QTc >  msec using Fridericia correction on screening electrocardiography (ECG)\r\n* Uncontrolled hypertension (systolic pressure >=  mmHg or diastolic pressure >=  mmHg on repeated measurement) despite optimal medical management; initiation or adjustment of anti-hypertensive medications are allowed prior to screening
CERITINIB EXCLUSION CRITERIA: Cardiovascular disorders including:\r\n* Symptomatic congestive heart failure (New York Heart Association class III or IV)\r\n* Personal or family history of congenital long QT syndrome\r\n* Corrected QTc >  msec using Fridericia correction on screening electrocardiography (ECG)\r\n* Uncontrolled hypertension (systolic pressure >  mmHg or diastolic pressure >  mmHg on repeated measurement) despite optimal medical management
REGORAFENIB EXCLUSION CRITERIA: Cardiovascular disorders including:\r\n* Symptomatic congestive heart failure (New York Heart Association class III or IV)\r\n* Personal or family history of congenital long QT syndrome\r\n* Corrected QTc >  msec using Fridericia correction on screening electrocardiography (ECG)\r\n* Uncontrolled hypertension (systolic pressure >  mmHg or diastolic pressure >  mmHg on repeated measurement) despite optimal medical management
ENTRECTINIB EXCLUSION CRITERIA: Cardiovascular disorders including:\r\n* Symptomatic congestive heart failure (New York Heart Association class III or IV)\r\n* Personal or family history of congenital long QT syndrome\r\n* Corrected QTc >  msec using Fridericia correction on screening electrocardiography (ECG)\r\n* Uncontrolled hypertension (systolic pressure >  mmHg or diastolic pressure >  mmHg on repeated measurement) despite optimal medical management
Uncontrolled hypertension defined as systolic blood pressure >  mmHg or diastolic pressure >  mmHg, despite optimal medical management
Uncontrolled arterial hypertension despite optimal medical management (per institutional guidelines).
Subjects who have a history or current evidence of uncontrolled hypertension defined as systolic blood pressure >  mmHg or diastolic blood pressure >  mmHg at screening despite optimal medical management; subjects with a history of mild to moderate hypertension are eligible at the investigators discretion if the hypertension is adequately controlled by antihypertensive treatment used at a stable dose for at least  weeks before the start of study treatment
Uncontrolled hypertension (HTN) despite medical management (blood pressure [BP] >= /)
Uncontrolled hypertension, defined as systolic blood pressure >  mmHg or diastolic pressure >  mmHg, despite optimal medical management
Uncontrolled hypertension (> / mmHg despite optimal medical therapy)
Uncontrolled hypertension defined as systolic blood pressure >  mmHg or diastolic pressure >  mmHg, despite optimal medical management
Uncontrolled hypertension defined as systolic blood pressure >  mmHg or diastolic pressure >  mmHg, despite optimal medical management
Uncontrolled hypertension (systolic pressure >  mmHg or diastolic pressure >  mmHg [NCI-CTCAE v.] on repeated measurement) despite optimal medical management
Uncontrolled hypertension  blood pressure >= / mmHg despite medical therapy
Subjects who have a history or current evidence of uncontrolled hypertension defined as systolic blood pressure ? mmHg or diastolic blood pressure ? mmHg at screening despite optimal medical management.
Uncontrolled arterial hypertension despite optimal medical management (per investigator's assessment).
Uncontrolled hypertension; (systolic blood pressure >  mmHg or diastolic pressure >  mmHg despite optimal medical management)
Uncontrolled hypertension defined as systolic blood pressure > mmHg or diastolic blood pressure > mmHg, despite optimal medical management.
Hypertension as defined by systolic blood pressure >  mmHg or diastolic blood pressure >  mmHg despite optimal medical management
Uncontrolled hypertension defined as systolic blood pressure >  mmHg or diastolic pressure >  mmHg, despite optimal medical management
Unstable hypertension defined as a systolic blood pressure >  mmHg or diastolic pressure >  mmHg despite optimal medical management
Uncontrolled hypertension (systolic pressure >  mmHg or diastolic pressure >  mmHg (National Cancer Institute Common Terminology Criteria for Adverse Events [NCI-CTCAE] version [v].) on repeated measurement) despite optimal medical management
Uncontrolled hypertension defined as systolic blood pressure >  mmHg or diastolic pressure >  mmHg, despite optimal medical management
Uncontrolled hypertension (systolic blood pressure [BP] >  mmHg or diastolic pressure >  mmHg despite optimal medical management).
Uncontrolled hypertension (blood pressure ? / mmHg despite optimal medical management)
b. Uncontrolled hypertension (systolic blood pressure >  mm Hg or diastolic blood pressure >  mmHg despite optimal medical management)
Systolic blood pressure >  mmHg or diastolic pressure >  mmHg despite optimal medical management
Uncontrolled hypertension defined as systolic blood pressure >  mmHg or diastolic pressure >  mmHg despite optimal medical management
Uncontrolled arterial hypertension despite optimal medical management (per investigator's assessment) (modified by amendment )
Uncontrolled hypertension defined as systolic pressure >  mmHg or diastolic pressure >  mmHg despite optimal medical management
Uncontrolled hypertension despite optimal medical management
Have uncontrolled hypertension (systolic blood pressure [SBP] greater than mmHg or diastolic blood pressure [DBP] greater than  mmHg) despite optimal medical management.
Uncontrolled hypertension defined as systolic blood pressure >  mmHg or diastolic pressure >  mmHg, despite optimal medical management
Patients with uncontrolled intracranial hypertension syndrome (defined as: persistence of headache, transient visual obscurations, and/or diplopia despite optimal clinical management) or uncontrolled seizure activity (i.e. recorded despite optimal medical management)
Uncontrolled hypertension defined as systolic blood pressure > mmHg or diastolic blood pressure > mmHg, despite optimal medical management
History of uncontrolled hypertension (systolic >  mmHg or diastolic pressure >  mmHg) despite optimal medical management
Uncontrolled hypertension defined as systolic blood pressure > mmHg or diastolic blood pressure > mmHg, despite optimal medical management and stable antihypertensive treatment for more than  days before the first dose of study drug
Uncontrolled hypertension defined as systolic blood pressure > mmHg or diastolic blood pressure > mmHg on  or more consecutive blood pressure readings, despite optimal medical management
Uncontrolled hypertension (systolic pressure >  mmHg or diastolic pressure >  mmHg on repeated measurement) despite optimal medical management
Uncontrolled hypertension (systolic blood pressure > millimeters of mercury [mmHg] or diastolic pressure > mmHg despite optimal medical management).
Uncontrolled hypertension defined as systolic blood pressure >  mmHg or diastolic pressure >  mmHg, despite optimal medical management
Uncontrolled hypertension defined as systolic blood pressure >  mmHg or diastolic pressure >  mmHg, despite optimal medical management
Uncontrolled hypertension, defined below:\r\n* Patients <  years old:\r\n** Diastolic Blood Pressure Within The Upper Limit Of Normal Defined as: A diastolic blood pressure (DBP) > the th percentile for age and gender despite optimal medical management\r\n* Patients >=  years old\r\n** Uncontrolled hypertension defined as systolic blood pressure >  mmHg or diastolic pressure >  mmHg despite optimal medial management
Uncontrolled hypertension (systolic pressure >  mmHg or diastolic pressure >  mmHg on repeated measurement) despite optimal medical management
Uncontrolled chronic hypertension defined as systolic >  or diastolic >  despite optimal therapy