Participant must not have a history of a coagulopathy or a platelet disorder. History of coagulopathy Known coagulopathy, platelet disorder or history of non-drug-induced thrombocytopenia Uncontrolled coagulopathy Has a clinically significant coagulopathy per investigators assessment Has evidence or a coagulopathy or hemostasis problem. Uncontrolled coagulopathy Active coagulopathy uncorrectable coagulopathy Active coagulopathy Patients with coagulopathy with an elevated INR ?., or platelets < Current Grade or higher coagulopathy, thrombosis and/or hemostasis disorders, History of clinically significant coagulopathy Coagulopathy tests will be obtained within weeks of enrollment Uncontrolled coagulopathy Has a clinically significant coagulopathy per investigators assessment History of coagulopathy, platelet disorder or history of non-drug induced thrombocytopenia Coagulopathy characterized by an INR >. without other known causes. Coagulopathy which contraindicates transperineal and intraprostatic needle insertion Known, existing uncontrolled coagulopathy Known, existing coagulopathy or receiving anticoagulants Known, existing uncontrolled coagulopathy History of coagulopathy or known thrombophilias Known, existing uncontrolled coagulopathy Known, existing uncontrolled coagulopathy No history of clinical coagulopathy No known coagulopathy Nonreversible or uncorrectable coagulopathy. INR should not be >., Participants with known coagulopathy, platelet disorder or history of non-drug-induced thrombocytopenia Pre-existing coagulopathy Uncorrected coagulopathy Subjects with uncorrected coagulopathy Uncorrectable coagulopathy Coagulopathy Patient has an uncorrectable coagulopathy Uncontrollable coagulopathy Coagulopathy Coagulopathy Uncorrectable coagulopathy Uncorrectable coagulopathy Known coagulopathy Uncorrectable coagulopathy prohibiting biopsy. (INR > . and/ or platelets < ,) Coagulopathy Evidence of a coagulopathy