For all patients:\r\n* Radiation dose should range from cGy to cGy\r\n* No treatment for this disease following radiation therapy Prior radiation therapy with cGY or more of TBI. Prior radiation therapy with cGy or more of TBI. Patient must be able to pass radiation evaluation (i.e.: able to receive cGy) Any prior therapeutic radiation therapy > cGy has been delivered Have received radiation therapy with concurrent temozolomide; total radiation dosage can range from to cGy administered in daily fractions of to cGy over weeks, or the equivalent in a hypofractionated protocol (for example, cGy in fractions or cGy in fractions); patients who are MGMT negative do not need to have received temozolomide Prior radiation doses equivalent to, or greater than, cGy to the target lesions at cGy fractions at any timepoint No thoracic radiation > cGy allowed Significant prior external beam dose-limiting radiation to a critical organ based on review of the prior radiation treatment records by the Radiation Oncology PI; patients who have had prior external beam radiation > cGy (at to cGy per day) to the lung will be ineligible; patients with ANY prior radiation to the heart are ineligible; patients with > cGy to the kidney will be excluded from the study; Note: patients who have had electron beam therapy are still eligible and will be evaluated on a case by case basis by the Radiation Oncology PI Patients who had prior radiation to more than % bone marrow containing areas or to any areas exceeding cGy Patients will be ineligible if any prior therapeutic radiation therapy > cGy has been delivered Significant prior external beam dose-limiting radiation to a critical organ based on review of the prior radiation treatment records by the radiation oncology PI; patients who have had prior external beam radiation > cGy (at to cGy per day) to any portion of the lung will be ineligible; patients with ANY prior radiation to the heart are ineligible; patients with > cGy to any portion of the kidney will be excluded from the study Kidney: cGy Liver: cGy Lungs: cGy Previous irradiation that precludes the safe administration of an additional dose of cGy of TBI Patients undergoing a total body irradiation (TBI)-based conditioning regimen (TBI cGy) Patients will be ineligible if any prior therapeutic radiation therapy > cGy has been delivered to the target volume Prior radiation therapy with cGy or more of TBI; if cGy of prior TBI then only cGy of TBI on this protocol is permitted Patients will be ineligible if any prior therapeutic radiation therapy > cGy has been delivered to the target volume Patients will be ineligible if any prior therapeutic radiation therapy > cGy has been delivered to the central nervous system Previous radiation therapy to more than % of bone marrow containing areas, or to any area exceeding cGy, is an exclusion Patients who have received > cGy radiation to the kidneys will be excluded from the study Patients are not eligible if they have received local radiation which includes any of the following: centigray (cGy) to more than % of both kidneys (patient must have at least kidney that has not exceeded the dose/volume of radiation listed) or cGy to more than % of liver and/or cGy to more than % of liver; emergency local irradiation is allowed prior to study entry, provided the patient still meets eligibility criteria Received >= centigray (cGy) radiation to the heart/chest >= Ten years post-radiation therapy following an accumulated dose of >= cGY to the heart/chest Receiving a dose of radiation therapy greater than or equal to centigray (cGy) to one third of the oral cavity Current diagnosis of cancer that supports the use of continuous definitive or adjuvant external-beam RT to the pelvis to a minimum dose of cGy with the following parameters:\r\n* The pelvis must be encompassed by the planned RT fields; the superior border may not lie inferior to the most inferior aspect of the sacroiliac joints; portions of the rectum may have special blocking, depending upon disease site\r\n* The total prescription dose must lie between - cGy (inclusive); a boost to primary tumor or tumor bed may be planned\r\n* Planned treatment is to be given - times per week on a onetreatment-per-day basis; the daily prescribed dose must lie between - cGy (inclusive) per day Patient must be cleared pre-transplant by Radiation Oncology to be able to receive cGy Patients whose clinical treatment plans include a continuous course of external beam radiotherapy by intensity-modulated radiation therapy (IMRT) and/or image-guided radiation therapy (IGRT), given as a cumulative dose of centigray (cGy) in single daily fractions of - cGy, combined with a concurrent course of weekly or tri-weekly cisplatin or carboplatin chemotherapy