No presence of cardiac disease that, in the opinion of the investigator, increases the risk of ventricular arrhythmia Significant cardiac event (eg, myocardial infarction), New York Heart Association (NYHA) classification of heart disease >= within weeks before starting treatment, or presence of cardiac disease that in the opinion of the Investigator increases the risk of ventricular arrhythmia Presence of cardiac disease that, in the opinion of the investigator, increases the risk of ventricular arrhythmia History of myocardial infarction within months with a residual arrhythmia that in the opinion of the investigator, increases the risk of ventricular arrhythmia Significant cardiac event (e.g., myocardial infarction), superior vena cava syndrome, New York Heart Association (NYHA) classification of heart disease >= within weeks, or presence of cardiac disease that in the opinion of the investigator increases the risk of ventricular arrhythmia History of any significant cardiac event (e.g. myocardial infarction), superior vena cava syndrome, New York Heart Association (NYHA) classification of heart disease >= within weeks before starting treatment, or presence of cardiac disease that in the opinion of the Investigator increases the risk of ventricular arrhythmia Clinically significant cardiovascular event (e.g. myocardial infarction, superior vena cava syndrome [SVC], New York Heart Association [NYHA] classification of heart disease >= within months before entry); or presence of cardiac disease that, in the opinion of the Investigator, increases the risk of ventricular arrhythmia Patients must not have had a clinically significant cardiac event within months before entry; or the presence of any other uncontrolled cardiovascular conditions that, in the opinion of the Investigator, increases the risk of ventricular arrhythmia. Clinically significant cardiovascular event (e.g. myocardial infarction, superior vena cava syndrome [SVC], New York Heart Association [NYHA] classification of heart disease >= within months before entry; or presence of cardiac disease that, in the opinion of the investigator, increases the risk of ventricular arrhythmia