With the exception of alopecia or toxicities related to the use of gonadotropin-releasing hormone agonists any unresolved toxicities from prior therapy greater than CTCAE grade at time of study treatment Patients in whom prior treatment related toxicities have not recovered to grade or less (except for alopecia) With the exception of alopecia, any unresolved toxicities from prior therapy greater than CTCAE Grade at the time of starting study treatment. Toxicities related to prior therapy must have returned to Grade or less, except for alopecia. Any unresolved toxicities from prior therapy greater than CTCAE grade at the time of starting study treatment, with the exception of alopecia or neuropathy Resolution of all clinically significant treatment-related, non-hematological toxicities, except alopecia, from any previous cancer therapy to =< grade prior to the first dose of study treatment All prior treatment-related toxicities must be CTCAE (version .) =< grade (except alopecia) at the time of randomization Resolution of all treatment-related, non-hematological toxicities, except alopecia, from any previous cancer therapy to < grade prior to the first dose of study treatment For participants entering cohorts C or D, prior treatment-related toxicities should have resolved to grade or baseline (with the exception of anemia (as per inclusion criteria, alopecia, and neuropathy [=< grade allowed]) Prior radiation or surgery must have completed at least weeks prior to initiation of therapy and all toxicities or complications from these must have resolved to baseline or grade prior to starting therapy (with the exception of anemia (as per inclusion criteria, alopecia, and neuropathy [=< grade allowed]) All acute treatment-related toxicities from prior therapy must have resolved to grade =< prior to study entry excluding alopecia Has no prior treatment-related toxicities >Grade (except alopecia) at the time of enrolment. Resolution of all treatment-related toxicities, except alopecia, anemia and neuropathy, from any previous cancer therapy to ? Grade prior to the first dose of study treatment. Any unresolved toxicities from prior therapy greater than CTCAE Grade at the time of starting study treatment with the exception of alopecia and Grade , prior platinum-therapy related neuropathy. No toxicities related to prior treatment related toxicities with the exception of alopecia and neuropathy Recovery of all chemotherapy or radiation-related toxicities to grade =< , except for alopecia and peripheral neuropathy All acute toxicities from prior therapy with the exception of alopecia must have resolved to =< grade Any unresolved toxicities from prior therapy greater than CTCAE grade at the time of starting study treatment with the exception of alopecia and grade , prior platinum-therapy related neuropathy Patients must demonstrate resolution of all toxicities related to prior chemotherapy, endocrine therapy, or biologic therapy to grade =< , including peripheral neuropathy, with the exception of alopecia (any grade permissible) All prior treatment-related toxicities must be CTCAE v grade =< (except alopecia) at the time of randomization Except for alopecia, any unresolved toxicities from prior therapy greater than CTCAE Grade at the time of starting study treatment. All prior treatment-related toxicities must be CTCAE v grade =< (except alopecia) at the time of randomization Resolution of treatment-related toxicities except alopecia All grade >= toxicities other than alopecia from prior therapy have resolved by the time of study commencement With the exception of alopecia or toxicities related to the use of gonadotropinreleasing hormone agonists, any unresolved toxicities from prior therapy greater than CTCAE Grade at the time of starting study treatment. Unresolved toxicities from prior therapy with the exception of alopecia that have not resolved to ? Grade at the time of starting study treatment With the exception of alopecia, any unresolved toxicities from prior chemotherapy should be no greater than CTCAE v grade at the time of starting study treatment Resolution of all prior treatment-related toxicities to Grade or less, except for Grade fatigue or alopecia prior to CD Must have full recovery from any toxicities from prior therapy CTCAE Grade or less with the exception of Grade alopecia) prior to randomization. All acute toxicities related to prior therapy must have resolved prior to study entry, except for alopecia and mild neuropathy All prior treatment related non-hematologic toxicities (with the exception of alopecia) must have resolved to CTCAE (Version .) ? Grade at the time of randomization. Failure to recover from all prior treatment-related non-hematological toxicities to ? Grade prior to the first scheduled dose of MEDI (except for alopecia and neuropathy).