History of thromboembolic or cerebrovascular events within the last months, including transient ischemic attack, cerebrovascular accident, deep vein thrombosis, or pulmonary embolism cerebrovascular accident, including transient ischemic attacks within the past months. No history of cerebrovascular accident, transient ischemic attacks, central nervous system or brain metastases Known active brain or central nervous system metastasis, or seizures requiring anticonvulsant treatment, cerebrovascular accident, or transient ischemic attack (< months prior to enrollment) History of prior cerebrovascular event, (including transient ischemic attack) within months of start of screening Any history of cerebrovascular accident or transient ischemic attack History of thromboembolic or cerebrovascular events within the last months, including transient ischemic attack, cerebrovascular accident, deep vein thrombosis, or pulmonary embolism (applicable to combination part only). PHASE I STUDY ELIGIBILITY CRITERIA:\r\nHistory of cerebrovascular accident, transient ischemic attack within year prior to study enrollment PHASE II STUDY COHORT TRIPLE NEGATIVE BREAST CANCER ELIGIBILITY CRITERIA (MEDI+O ONLY):\r\nHistory of cerebrovascular accident, transient ischemic attack within year prior to study enrollment PHASE II COLORECTAL CANCER COHORT (MEDI+C ONLY):\r\nHistory of cerebrovascular accident, transient ischemic attack within year prior to study enrollment Cerebrovascular accident or transient ischemic attack Cerebrovascular accident or transient ischemic attack within months prior to first dose. History of an ischemic insult in the previous months (myocardial infarction, cerebral vascular accident, ischemic tissue from injury, transient ischemic attack) Prior history of cerebrovascular accident or transient ischemic attack. Cerebrovascular accident or transient ischemic attack The subject has a history of loss of consciousness, cerebrovascular accident, or transient ischemic attack within months before the Day visit. Known active brain or central nervous system metastasis (less than month out from definitive radiotherapy or surgery), or seizures requiring anticonvulsant treatment, or clinically significant cerebrovascular accident or transient ischemic attack (< months) Prior history of cerebrovascular accident or transient ischemic attack, or pre-existing carotid artery disease Patients with a cerebrovascular accident or transient ischemic attack within the past six months History of cerebrovascular attack or transient ischemic attack within months prior to the initiation of therapy on this protocol Cerebrovascular accident or transient ischemic attack within months prior to first dose Prior history of cerebrovascular accident or transient ischemic attack History of cerebrovascular accident, including transient ischemic attack (TIA) History of cerebrovascular accident including transient ischemic attack within the past months Patients with cerebrovascular accident or transient ischemic attack within months of therapy are excluded No history of cerebrovascular accident or transient ischemic attacks History of cerebrovascular accident or transient ischemic attack. Thromboembolic events such as a cerebrovascular accident including transient ischemic attacks within the past months History of an ischemic insult in the previous months (myocardial infarction, cerebral vascular accident, ischemic tissue from injury, transient ischemic attack. No history of cerebrovascular accident or transient ischemic attacks within the past months from registration History of cerebrovascular attack or transient ischemic attack within months prior to the initiation of therapy on this protocol. Cerebrovascular accident or transient ischemic attack within years No history of cerebrovascular accident or transient ischemic attacks within the past months History of cerebrovascular accident within the past months (e.g. transient ischemic attack [TIA]) History of cerebrovascular accident or transient ischemic attack within months of first study dose Has an unstable neurological disease (e.g. cerebrovascular accident [including transient ischemic attacks (TIAs)]) within the months before signing of informed consent Uncontrolled active seizure disorder or history of cerebrovascular accident (CVA) or transient ischemic (TI) attack within the past months Cerebrovascular accident or transient ischemia.