Must not have known allergic reaction against any of the components of the study treatment Patient has previously taken ruxolitinib or is allergic to components of the study drug Patient with documented hypersensitivity to any of the components of the therapy program Patients with documented hypersensitivity to any components of the study program Patient with documented hypersensitivity to any of the components of the chemotherapy program Patient with documented hypersensitivity to any of the components of the chemotherapy program Patient with documented hypersensitivity to any of the components of the chemotherapy program Known prior severe allergic/hypersensitivity to the chemotherapy or any of the components of the study treatment Known allergic reaction to neratinib, pertuzumab, trastuzumab, paclitaxel, or any of their components Patient is allergic to components of the study drug; for arms A and B only, patient has perviously taken ibrutinib Any known allergic reaction to vaccine components