Alkaline phosphate =< x normal Alkaline phosphatase within upper limits of institutional normal within days prior to study entry Alkaline phosphatase =< . x institutional upper limit of normal Alkaline phosphatase < . x upper limit of normal if no documented liver disease or < x upper limit of normal if documented liver or bone disease Alkaline phosphatase =< times the upper limit of normal (unless clinically considered to be related to liver involvement with leukemia) Alkaline phosphatase =< x upper limit of normal Alkaline phosphatase =< . times the upper limit of normal Alkaline phosphatase =< . X institutional upper limit of normal, determined within days of registration PART I: Alkaline phosphatase (Alk PO) =< x the upper limits of normal (except for patients with documented metastatic disease to bone and/or liver) Bilirubin <= . mg/dL; ALT, AST, and alkaline phosphatase <= .x the upper limit of normal Alkaline phosphatase =< x upper limit of normal Alkaline phosphatase =< x upper limit of normal Alkaline phosphatase =< . x institutional upper limit of normal Alkaline phosphatase =< x institutional upper limit of normal within days of registration Alkaline phosphatase < x upper limit of normal Alkaline phosphatase =< . x normal prior to biopsy Alkaline phosphatase =< times upper limit normal Serum alkaline phosphatase less than . times the upper limits of normal Alkaline phosphatase =< . x upper limit (UL) Alkaline phosphatase =< x upper limit of normal, unless proven to be due to disease involvement Alkaline phosphatase < . x upper limit of normal Alkaline phosphatase =< times the upper limit of normal Alkaline phosphatase < x upper limit of normal Alkaline phosphatase < . times the upper limit of normal Alkaline phosphatase < times the upper limit of normal Alkaline phosphatase less than . x upper limit of normal Alkaline phosphatase < . times normal Alkaline phosphatase =< x the upper limit of normal; serum bilirubin > . is acceptable in the setting of known Gilberts syndrome Aspartate aminotransferase (AST) and alkaline phosphatase < x upper limit of normal AST and alkaline phosphatase < x upper limit of normal Alkaline phosphatase < times the upper limit of institutional normal Alkaline phosphatase must be no more than . times upper limit of normal unless due to disease involvement of the liver Alkaline phosphatase < times upper limit of normal Performed within days prior to study: Alkaline phosphatase < times the upper limits of the institutional normal Alkaline phosphatase =< x institutional upper limit of normal (IULN) Alkaline phosphatase < times upper limit of institutional normal Alkaline (Alk) phosphatase =< x upper limit of normal Alkaline phosphatase > x normal Within days of registration: Alkaline phosphatase =< x upper limit of normal Alkaline phosphatase =< . x institutional upper limit of normal Alkaline phosphatase =< X institutional upper limit of normal Alkaline phosphatase =< X institutional upper limit of normal No history of severe prior or ongoing chronic liver disease; alkaline phosphatase < x upper limit of normal Alkaline phosphatase =< . x upper limit of normal Alkaline phosphatase =< x institutional normal Alkaline phosphatase < x upper limit of normal, or considered not clinically significant by the study doctor or designee Alkaline phosphatase within times the upper limits of normal Alkaline phosphatase =< times the institutional upper limit of normal Alkaline phosphatase < . times institutional upper normal limit (unless due to disease involvement of the liver or bone marrow) Within days of registration: Alkaline phosphatase =< . institutional upper limit of normal Alkaline phosphates must be =< . X the upper limit of normal Alkaline phosphatase < times normal Alkaline phosphatase =< . times upper limit of normal (unless due to disease involvement of the liver or bone marrow) Alkaline phosphatase (AP) =< x institutional upper limit of normal Alkaline phosphatase > . times upper normal limit (unless due to chronic GVHD) Alkaline phosphatase =< . x institutional upper limit normal Alkaline phosphatase =< . x normal prior to biopsy Alkaline phosphatase =< . times upper limit of normal Alkaline phosphatase =< . x normal limits Alkaline phosphatase less than times the upper limit of normal (unless due to active myositis) Alkaline phosphatase < times the upper limit of laboratory normal Alkaline phosphatase =< times upper limit of laboratory normal Alkaline phosphatase less than or equal to . x upper limit of normal, CTCAE v . grade Alkaline phosphatase =< . times the upper limit of normal unless hepatic dysfunction is related to liver involvement with disease Alkaline phosphatase =< . X upper limit of normal Alkaline phosphatase =< . x upper limit of normal Alkaline phosphatase < . times the upper limit of normal; in patients with liver metastasis, liver function tests should be < times the upper limit of normal Alkaline phosphatase (hepatic) > times the upper normal limit Serum alkaline phosphatase less than . times the upper limits of normal Alkaline phosphatase =< x upper limit of normal Alkaline phosphatase =< . X upper limit of normal Alkaline phosphatase < X upper limit of normal Alkaline phosphatase < x upper limit of normal Alkaline phosphatase (hepatic) > times the upper normal limit Alkaline phosphatase < . X institutional upper limit of normal Alkaline phosphatase =< x upper limit of normal Obtained =< days prior to registration: Alkaline phosphatase =< x the institutional upper limit of normal Alkaline phosphatase =< . x the upper normal limit Alk phosphatase =< times institutional upper limit of normal Alkaline phosphatase =< . x upper limit of normal Alkaline phosphatase < times the upper limit of normal (alkaline phosphatase and aspartate aminotransferase [AST] cannot both exceed the upper limit of normal) AST < times upper limit of normal (alkaline phosphatase and AST cannot both exceed the upper limit of normal) Alkaline phosphatase (ALP) must be < times the upper limit of normal Alkaline phosphatase < x upper limit of normal Liver alkaline phosphatase =< x upper limit of normal Alkaline phosphatase < . x the upper limit of normal Alkaline phosphatase within institutional limits of normal or judged to be not clinically significant by the investigator Alkaline phosphatase =< . x upper limit of institutional normal Alkaline phosphatase =< . x institutional upper limit of normal Alkaline phosphatase must be less than x upper limit of normal Alkaline phosphatase =< times the upper limit of normal Alkaline phosphatase =< . x upper limits of normal if no liver metastases present; alkaline phosphatase =< x upper limits of normal if liver metastases present Alkaline phosphatase within normal limits