Active infection requiring parenteral or oral antibiotics within weeks before planned start of study therapy Known active infection requiring parenteral or oral anti-infective treatment within days of randomization. Current infection requiring parenteral antibiotics Known active infection requiring parenteral or oral anti-infective treatment, once a patient has completed antibiotics and symptoms of infection have resolved to < grade , they are then considered eligible from an infection standpoint Active infection requiring parenteral antibiotics within weeks before planned first dose of study drug Serious/active infection or infection requiring parenteral antibiotics Current infection requiring parenteral antibiotics Known active infection requiring parenteral or oral anti-infective treatment within days of initiation of therapy Current infection requiring parenteral antibiotics Have uncontrolled intercurrent illness including, but not limited to, an ongoing/active infection requiring parenteral antibiotics. Known active infection requiring parenteral anti-infective treatment at the time of initiation of treatment Active infection requiring parenteral antibiotics Serious/active infection or infection requiring parenteral antibiotics Patients with acute hepatitis or active infection that requires parenteral antibiotics Active infection requiring parenteral antibiotics Subjects with active infection that requires parenteral antibiotics Active infection requiring parenteral antibiotics Uncontrolled systemic infection requiring parenteral anti-microbial therapy. Active infection requiring parenteral antibiotics Major active infection requiring parenteral antibiotics. Active infection requiring parenteral antibiotics Active infection requiring parenteral antibiotics. Uncontrolled active infection; patients with infection requiring parenteral antibiotics are eligible if the infection is controlled Patients must not have an active infection requiring current treatment with parenteral antibiotics Patients with acute hepatitis or active infection that requires parenteral antibiotics Patients with active infection requiring parenteral antibiotics. Known active infection requiring parenteral or oral anti-infective treatment Ongoing infection that requires parenteral treatment with antibiotics Uncontrolled active systemic infection or recent infection requiring parenteral anti-microbial therapy Current infection requiring parenteral antibiotics Subjects with active infection that requires parenteral antibiotics Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection requiring parenteral antibiotics on day Known active infection requiring parenteral or oral anti-infective treatment Serious/active infection or infection requiring parenteral antibiotics Patients with acute hepatitis or active infection that requires parenteral antibiotics are excluded Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection requiring parenteral antibiotics on day Patients with acute hepatitis or active infection that requires parenteral antibiotics. Patients must not have a serious intercurrent illness including, but not limited to, ongoing or active infection requiring parenteral antibiotics Known active infection requiring parenteral or oral anti-infective treatment. Ongoing or active infection requiring parenteral antibiotics. Any active infection requiring the use of parenteral anti-microbial agents or that is > Grade ; Uncontrolled active infection; patients with infection requiring parenteral antibiotics are eligible if the infection is controlled Serious/active infection or infection requiring parenteral antibiotics Active infection requiring parenteral antibiotics The patient has ongoing or active infection requiring parenteral antibiotics. Patients with any other serious/active/uncontrolled infection, any infection requiring parenteral antibiotics, or unexplained fever > C within week prior to first study drug administration. Serious infection requiring parenteral antibiotics within days of enrollment Patients with any other serious/active/uncontrolled infection, any infection requiring parenteral antibiotics, or unexplained fever > C within weeks prior to first study drug administration. Serious/active infection or infection requiring parenteral antibiotics Active infection requiring parenteral antibiotics within one-week prior to study Active infection requiring parenteral antibiotics Have had an infection requiring the use of parenteral antibiotics within days prior to the start of Day ; Any infection requiring parenteral antibiotics within the past weeks No active infection within days of study enrollment requiring parenteral antibiotics Known active infection requiring parenteral or oral anti-infective treatment within defined period Current infection requiring parenteral antibiotics