Patients with any known brain or leptomeningeal metastases are excluded, even if treated.
Untreated or symptomatic brain metastases and leptomeningeal disease
Patients with brain metastases (treated or untreated) leptomeningeal disease, uncontrolled seizure disorder, or active neurologic disease
Patients with uncontrolled brain or leptomeningeal metastases, including patients who continue to require glucocorticoids for brain or leptomeningeal metastases
No history or evidence by CT scan or MRI, of brain metastases or leptomeningeal disease.
Uncontrolled brain or leptomeningeal metastases, including patients who continue to require glucocorticoids for brain or leptomeningeal metastases; asymptomatic or treated brain metastases are acceptable
Uncontrolled brain or leptomeningeal metastases from plexiform neurofibromas, malignant peripheral nerve sheath tumors, or other cancers (other than proven or probable low grade astrocytomas), including patients who continue to require glucocorticoids for control of symptoms related to brain or leptomeningeal metastases
Any known brain or leptomeningeal metastases are excluded, even if treated.
Have symptomatic brain metastases or leptomeningeal disease
Known brain metastases or leptomeningeal disease involvement. Glioblastoma lesions (primary or locally advanced) are eligible.
Known brain or leptomeningeal metastases
Subject has known symptomatic brain metastases or leptomeningeal involvement as assessed by CT scan or MRI. Subjects with stable asymptomatic brain metastases or leptomeningeal disease are eligible provided that they have not required new treatments for this disease in a  day period before the first dose of study drug, and anticonvulsants and steroids have not been administered for a period of  weeks prior to the first dose of study drug.
Known symptomatic uncontrolled brain or leptomeningeal metastases (Day )
Uncontrolled brain or leptomeningeal metastases, including patients who continue to require glucocorticoids for brain or leptomeningeal metastases.
Uncontrolled brain or leptomeningeal metastases, including patients who continue to require glucocorticoids for brain or leptomeningeal metastases
Current or previously treated brain or leptomeningeal metastases
Current or previously treated brain or leptomeningeal metastases
Clinical evidence of symptomatic progressive brain or leptomeningeal disease during the past  months
Known or suspected leptomeningeal disease; patients with metastases to the brain stem, midbrain, pons or medulla
Untreated brain metastases, treated brain metastases that are not stable, leptomeningeal disease, or seizures uncontrolled with standard medical therapy
Documented and/or symptomatic or known brain or leptomeningeal metastases
Uncontrolled brain or leptomeningeal metastases, including patients who continue to require glucocorticoids for brain or leptomeningeal metastases
Uncontrolled brain or leptomeningeal metastases, including those who continue to require glucocorticoids for brain or leptomeningeal metastases
Untreated brain or leptomeningeal metastases, including patients who continue to require glucocorticoids for brain or leptomeningeal metastases
Untreated brain or leptomeningeal metastases, including patients who continue to require glucocorticoids for brain or leptomeningeal metastases
Extensive active brain disease including symptomatic brain metastases or presence of leptomeningeal disease
Patients with symptomatic brain metastases who have not completed radiation therapy and/or are receiving systemic steroid therapy; patients with leptomeningeal disease will be excluded
The participant has documented brain metastases or leptomeningeal disease.
Confirmed brain and/or leptomeningeal metastases
Patients must not have symptomatic uncontrolled brain or leptomeningeal metastases.
Active brain or leptomeningeal metastases, including patients who continue to require glucocorticoids for brain or leptomeningeal metastases; treated, asymptomatic metastases are permitted provided the patient has been off steroids for at least  month prior to day  of study drug
Subject has known or suspected primary brain or leptomeningeal metastases
Subject has known symptomatic brain metastases or leptomeningeal involvement as assessed by CT scan or MRI. Subjects with stable asymptomatic brain metastases or leptomeningeal disease are eligible if they have not required new treatments for this disease in a  day period before the first dose of study drug, and anticonvulsants and steroids have not been administered for a period of  weeks prior to the first dose of study drug.
Brain metastases or leptomeningeal disease
Uncontrolled brain or leptomeningeal metastases, including patients who continue to require glucocorticoids for brain or leptomeningeal metastases
Metastatic brain or leptomeningeal tumors (treated metastatic brain or leptomeningeal tumors are allowed)
Uncontrolled brain or leptomeningeal metastases, including patients who continue to require glucocorticoids for brain or leptomeningeal metastases
Uncontrolled brain or leptomeningeal metastases, including patients who continue to require glucocorticoids for brain or leptomeningeal metastases
A history of or evidence of brain metastases or leptomeningeal disease.
Uncontrolled brain or leptomeningeal metastases, including patients who continue to require glucocorticoids for brain or leptomeningeal metastases
Patients with brain or central nervous system metastases, including leptomeningeal disease
Leptomeningeal disease or any untreated or symptomatic brain metastases, unless the following criteria are met:
Has active brain metastasis or leptomeningeal carcinomatosis; patients with adequately treated brain metastases are eligible if they meet certain criteria
Uncontrolled brain or leptomeningeal metastases, including patients who continue to require glucocorticoids for brain or leptomeningeal metastases
Brain metastases, leptomeningeal disease, uncontrolled seizure disorder, or active neurologic disease
Brain or leptomeningeal metastases that are symptomatic and/or requiring treatment
Patients with brain metastases (treated or untreated) leptomeningeal disease, uncontrolled seizure disorder, or active neurologic disease
Uncontrolled brain metastases or leptomeningeal involvement; patients with brain metastases are permitted if they have received appropriate therapy and demonstrated control of the brain metastases or leptomeningeal disease following therapy; patients with known brain metastases will require magnetic resonance imaging (MRI) brain to demonstrate disease control prior to enrollment (lack of symptom progression for two weeks off therapeutic doses of steroids, excluding chronic steroids used for control of chronic obstructive pulmonary disease [COPD])
Subjects with brain metastases, leptomeningeal disease, uncontrolled seizure disorder, or active neurologic disease
Patients with untreated or uncontrolled brain metastases or leptomeningeal disease
Current or a prior history of brain metastases or leptomeningeal disease. Must not have rapidly progressive, life-threatening metastases.
Symptomatic uncontrolled brain or leptomeningeal metastases
Symptomatic uncontrolled brain or leptomeningeal metastases.
Uncontrolled brain or leptomeningeal metastases, including patients who continue to require glucocorticoids for brain or leptomeningeal metastases
Known brain metastases not radiographically stable for ? months or leptomeningeal disease
Uncontrolled brain or leptomeningeal metastases, including patients who continue to require glucocorticoids for brain or leptomeningeal metastases; treated brain metastases must have been stable for at least  months
Uncontrolled brain or all leptomeningeal metastases, including patients who continue to require glucocorticoids for brain or leptomeningeal metastases
The participant has uncontrolled brain or leptomeningeal metastases
Untreated or symptomatic brain metastases or leptomeningeal disease
Symptomatic, progressive or corticosteroids-requiring documented brain metastases or leptomeningeal disease involvement.