Known intolerance to either of the study drugs (or any of the excipients) Known allergy or hypersensitivity to any of the study drugs or their excipients. History of allergy or hypersensitivity to any study drugs or their excipients Known allergy or hypersensitivity to any of the study drugs or any of the study drug excipients. Known hypersensitivity to afatinib or the excipients of any of the trial drugs Any known hypersensitivity to bevacizumab, erlotinib or other excipients of these drugs Known allergy or hypersensitivity to any of the study drugs or any of the study drug excipients. Known allergy or hypersensitivity to any of the study drugs or any of the study drug excipients. Known hypersensitivity to gemcitabine (or other drug excipients) or chemically related drugs. Subjects with known hypersensitivity to study drugs or their excipients Known allergy or hypersensitivity to any of the study drugs or any of their excipients Subjects with known hypersensitivity to study drugs or their excipients Known allergy or hypersensitivity to any of the study drugs or any of the study drug excipients Known hypersensitivity to afatinib or the excipients of any of the trial drugs History of allergy or hypersensitivity to any of the study drugs. Known allergy or hypersensitivity to any of the study drugs or any of the study drug excipients Known allergy or hypersensitivity to study treatment or any of the study drugs excipients. Allergy/sensitivity to any study drug (gemcitabine, cisplatin, enzalutamide), or drugs chemically related to study drug, or excipients Subjects who have a history of hypersensitivity to any of the study drugs or their excipients, or a history of severe hypersensitivity to any other antigen Known hypersensitivity to any of the study drugs or any of the ingredients or excipients of these drugs (e.g., polysorbate ), including sensitivity to benzyl alcohol Known hypersensitivity to afatinib, dasatinib, or the excipients of any of the trial drugs Subject has a history of allergy or hypersensitivity to any study drugs or their excipients. Known hypersensitivity to any of the study drugs or excipients Known hypersensitivity to any of the study drugs or excipients Known hypersensitivity to the trial drugs or to their excipients Known hypersensitivity to afatinib or letrozole or the excipients of any of the trial drugs. Subjects who have a history of hypersensitivity to any of the study drugs or their excipients, or a history of severe hypersensitivity to any other Antigen. Known hypersensitivity to the study drugs or excipients of the preparations or any agent given in association with this study. Known hypersensitivity to any of the study drugs or excipients Subjects with hypersensitivity to study drugs or their excipients A known history of allergy or hypersensitivity to any of the study drugs or any of their excipients. Hypersensitivity to one of the trial drugs or the excipients. Have a known allergy to resiquimod or any of the excipients in the study drug Known intolerance to either of the study drugs (or any of the excipients) Known intolerance to any of the study drugs (or any of the excipients) A known history of allergy or hypersensitivity to any of the study drugs or any of their excipients. Known hypersensitivity to the trial drugs, to their excipients or to contrast media Known hypersensitivity to afatinib (BIBW ) or the excipients of any of the trial drugs History of hypersensitivity to any of the study drugs or to any excipients. Patient has a history of allergy or hypersensitivity to the study drugs Patient has a history of allergy or hypersensitivity to the study drugs Known hypersensitivity to the study drugs or excipients of the preparations or any agent given in association with this study Known allergy to any of the study drugs or their excipients. Patient who has a history of allergy or hypersensitivity to any of the study drugs Known hypersensitivity to any of the study drugs or its excipients. Known hypersensitivity to bevacizumab or any of its excipients, or any SOC drugs foreseen Known significant hypersensitivity to study drugs or excipients Known hypersensitivity or idiosyncratic reaction to any of the study drugs (Sodium Cridanimod, megestrol acetate, lidocaine) and excipients; Allergy/sensitivity to any study drug (degarelix, enzalutamide, trametinib, dasatinib), or drugs chemically related to study drug, or excipients or to dimethylsulfoxide