Serum total cholesterol level =< mg/dL Patients must have a serum triglyceride level =< mg/dL and serum cholesterol level =< mg/dL; if an initial random draw (i.e. non-fasting) is out of range, it is acceptable to repeat this test as a fasting draw Patients with uncontrolled hyperlipidemia (total cholesterol > or triglycerides > ) are NOT eligible for participation Serum triglyceride level =< mg/dL and serum cholesterol =< mg/dL; if these labs were drawn non-fasting and do not meet the eligibility criteria then it is suggested that they are repeated fasting, i.e. no food or drink other than water for hours; the use of medication to achieve these parameters is not allowed Total cholesterol < mg/dL Patients must have cholesterol level < mg/dL and triglycerides < mg/dL before starting therapy; in case one or both of these are exceeded, the patient can only be included after initiation of appropriate lipid lowering medication and documentation of cholesterol < mg/dL and triglycerides < mg/dl before start of therapy Fasting serum cholesterol =< mg/dL Serum cholesterol levels must be less than grade (< mg/dL), and serum triglyceride levels must be less than grade (< . x ULN) Fasting or non-fasting serum triglyceride level =< mg/dL and serum cholesterol level =< mg/dL Cholesterol =< mg/dL Serum total cholesterol level =< mg/dL within days prior to enrollment Serum cholesterol and serum triglyceride levels must be less than mg/dl Serum cholesterol and serum triglyceride levels must be < grade Fasting level of total cholesterol of no more than mg/dL Fasting cholesterol =< mg/dL; ONLY APPLICABLE for patients with NF mutation (GSK) Baseline cholesterol must be < mg/dL and triglycerides < mg/dL (with or without the use of antihyperlipidemic medications) Uncontrolled hyperlipidemia (total cholesterol > or triglycerides > ) Fasting serum cholesterol =< mg/dL OR =< . mmol/L SUB-PROTOCOL AIM A: Serum cholesterol =< mg/dL Fasting serum cholesterol less than or equal to mg/dL Have plasma total cholesterol < mg/dL Have plasma total cholesterol > mg/dL Serum cholesterol level =< mg/dL (. mmol/L) Subject has cholesterol panel and triglyceride done before first treatment May be on cholesterol medications Cholesterol > mg/dl or triglycerides > mg/dl despite treatment Cholesterol =< mg/dL Fasting level of total cholesterol of no more than mg/dL Fasting serum cholesterol =< mg/dL OR =< . mmol/L AND Serum cholesterol >= Grade Serum fasting triglyceride level =< mg/dL (=< . mmol/L) and serum cholesterol level =< mg/dL (=< . mmol/L) Low-density lipoprotein (LDL) -cholesterol ? mg/dL (individuals with elevated LDL-cholesterol will be referred for clinical management of dyslipidemia) Fasting cholesterol level < mg/dl Cholesterol =< mg/dL (. mmol/L) Total cholesterol =< mg/dl Have plasma total cholesterol < mg/dL Have plasma total cholesterol > mg/dL or plasma triglycerides > mg/dL