STEP I: Patients must not have active, uncontrolled seizure disorder; patients must have had no seizures in the last months Patients with a history of uncontrolled seizure disorder; including focal or generalized seizure may not have had a seizure within one year prior to registration Patients with uncontrolled seizure disorder are not eligible; (patients with seizure disorders that do not require antiepileptic drugs, or are well controlled with stable doses of antiepileptic drugs remain eligible) Patients with seizure disorder may be enrolled if on anti-convulsants and well controlled Patients with active seizures or a history of uncontrolled seizure disorder, including focal or generalized seizure within the past year Seizure disorders requiring anticonvulsant therapy. History of seizure disorder or active use of anticonvulsants History of uncontrolled seizure disorder Current or history of seizure disorder Patients who have an uncontrolled seizure disorder, or active neurological disease Subjects with a seizure disorder that is not well controlled or who have required a change in seizure medications within days of enrollment to the trial. History of seizure disorder. history of seizure disorder Patients with a seizure disorder should be well controlled Patients with seizure disorder may be enrolled if seizure disorder is well controlled Contraindication to the use of bupropion including seizure disorder or conditions that increase the risk of seizure (including bulimia and/or anorexia nervosa, central nervous system [CNS] tumor, severe stroke, abrupt withdrawal from benzodiazepines or alcohol) History of seizure disorder not related to underlying cancer Serum albumin ? g/dL. Neurologic Function: Patients with seizure disorder may be enrolled if seizure disorder is well controlled. History of seizure disorder Diagnosis of seizure disorder Seizures disorder not controlled by anti-seizure medications Any chronic or active neurologic disorder, including seizures and epilepsy, excluding a single febrile seizure as a child Any history of epilepsy or a seizure disorder or any known prior seizures. Patients will not be eligible if they present or have a history of seizure disorder Any chronic or active neurologic disorder, including seizures and epilepsy, excluding a single febrile seizure as a child Patients with history or presence of clinically significant neurological disorders such as epilepsy, generalized seizure disorder, severe brain injuries are ineligible Patients with a history of active seizures (or a single confirmed seizure event) in the last years from the time of registration Prior history of psychiatric disorder or seizure disorders which could be exacerbated by Interleukin- as judged by the treating investigator Uncontrolled seizure disorder (ie, seizures within the past months). Uncontrolled seizure disorder (ie, seizures within the past months). History of idiopathic seizure disorder, psychosis, or schizophrenia Known seizure disorder Clinically evident CNS metastases or leptomeningeal disease not controlled by prior surgery or radiotherapy; history of seizure disorder not controlled by anti-seizure medication at the time of enrollment. Patients with primary CNS malignancies are excluded. Seizure disorder requiring enzyme-inducing anti-epileptic drugs (EIAEDs)\r\n* Note: If the seizure disorder can be managed with agents that are not EIAEDs (e.g., levetiracetam or valproate), the patient should not be excluded Patients with active seizure or history of seizure are not eligible Prior history of seizure disorder Have a history of a seizure Documented uncontrolled seizure disorder a seizure disorder controlled with medication (i.e. no seizures in the previous months) will not exclude a patient Any chronic or active neurologic disorder, including seizures and epilepsy, excluding a single febrile seizure as a child Reports diagnosis of seizure disorder Any chronic or active neurologic disorder, including seizures and epilepsy, excluding a single febrile seizure as a child Clinically evident central nervous system metastases or leptomeningeal disease not controlled by prior surgery or radiotherapy; history of seizure disorder not controlled by anti-seizure medication at the time of enrollment. Patients with any seizure disorder Patients with any history of seizure or seizure disorder History of seizure disorder History of seizure disorder History of seizure disorder or clinically treated bipolar disorder Have a seizure disorder where > seizure has occurred within the last year. Seizure disorders requiring anticonvulsant therapy. Past or current history of epilepsy or seizure disorder; exception: well-documented febrile seizure of childhood Active seizure disorder uncontrolled by medication Patient has no known history of seizure disorder Uncontrolled seizure disorder Patients with a history of seizure disorder (except infant febrile seizures) Patients with seizure disorder may be enrolled if well controlled Active seizure or history of seizure disorder Known central nervous system (CNS) metastases or seizure disorder; patients with known brain metastases that have been successfully treated and stable for >= months without requirement for corticosteroids and without seizure activity will be eligible Patients with a high risk of seizures should be excluded from the protocol (e.g. those patients with an uncontrolled seizure disorder, and/or patients who have had a focal or generalized seizure within the last months) Uncontrolled seizure disorder Uncontrolled, active seizure disorder or a history of seizure Patients with a history of encephalitis, multiple sclerosis, or seizures within the last year (from seizure disorder or brain metastasis) should be excluded from this clinical trial Patients with active seizure or a history of seizure are not eligible Patients must NOT have active seizure(s) or history of seizure(s) PHASE II: Patients must NOT have active seizure(s) or history of seizure(s) Patients with a history of seizure disorder requiring antiepileptics who have had a seizure episode within the last months Patients with history of seizure disorder requiring antiepileptics who have had a seizure episode within the last months History of uncontrolled severe seizure disorder History of uncontrolled severe seizure disorder Patients who have an uncontrolled seizure disorder, or active neurological disease Patients must not have active, uncontrolled seizure disorder; patients must have had no seizures in the last months Patients who have had a seizure within months prior to enrollment and patients receiving anti-convulsant therapy for a seizure disorder. Patients must not have active seizure or history of seizure Uncontrolled seizure disorder, active neurological disease, or known CNS disease. A history of seizure within months prior to study entry. Patients with epilepsy, seizures, or predisposing factors for seizure as judged by the investigator. Uncontrolled seizure disorder Has a history of seizure Patients with seizure disorder may be enrolled if seizures are well controlled Concurrent therapy with medications known to have seizure potential past history of seizure due to any cause except a single febrile seizure in childhood. Patients with a history of seizures should not have had a seizure within months of Screening and must have had no anticonvulsants for months prior to Screening, History of epilepsy or seizure disorder History of idiopathic seizure disorder, psychosis or schizophrenia Patients with known or suspected brain metastases, carcinomatous meningitis, uncontrolled seizure disorder, active intracranial bleeding or active neurologic disorder are excluded Patients with uncontrolled seizure disorders No uncontrolled seizure disorders A history of uncontrolled seizure disorder Patients must not have a history of any type of seizure for at least years prior to registration. Seizure disorder Concurrent treatment with medications known to have seizure potential Patients must not have uncontrolled central nervous system disease; patients with a history of seizure disorders must be seizure-free for one year prior to enrollment Patients with seizure disorder may be enrolled if well controlled Active central nervous system (CNS) disorder or seizure disorder Uncontrolled seizure disorder or other serious neurological diseases Past or current history of epilepsy or seizure disorder Seizure disorders requiring anticonvulsant therapy History of seizure disorder Prior history of seizure disorder Uncontrolled seizure disorder or active neurologic disease Known brain metastases, uncontrolled seizure disorder, or active neurologic disease Known brain metastases, uncontrolled seizure disorder, or active neurologic disease History of seizure disorders Any history of brain metastases or prior seizure or conditions predisposing to seizure activity Uncontrolled seizure disorder or active neurologic disease Uncontrolled seizure disorder or active neurologic disease Uncontrolled seizure disorder requiring therapy (such as steroids or anti-epileptics with significant CYP interaction) Focal or generalized seizure within the last months. Seizure disorder requiring anticonvulsant therapy (such as steroids or anti-epileptics) Uncontrolled seizure activity. Uncontrolled seizure disorder. History of seizure disorder not related to underlying cancer. History of seizure Patients with active seizures or a history of seizure are not eligible for study entry, with the exception of patients with documented febrile seizure Donor must have adequate neurologic function as defined by NO evidence of a severe central or peripheral neurologic abnormality and no history of cerebrovascular accident or seizure disorder requiring anticonvulsant medication. Prior seizures < months prior to enrollment. Subjects with a history of seizure disorders ? months prior to enrollment must be seizure free and on stable anticonvulsant medication(s) for ? months prior to enrollment). Uncontrolled seizure disorder, active neurological disease, or greater than Grade neuropathy. Subjects with uncontrolled seizure Seizure disorders Have a known history of central nervous system disease (e.g., brain metastases or a seizure disorder) History of intractable epilepsy, or uncontrolled seizure disorder History of a seizure disorder diagnosis or have experienced a seizure in the past months PATIENTS: History of neuroleptic malignant syndrome or active seizure disorder (with seizure episode within the past week) Patient has an active seizure disorder; (patients with a previous history of seizure disorders will be eligible for the study, if they have had no evidence of seizure activity, and they have been free of anti-seizure medication for the previous years) Survivors who report ever being diagnosed with a seizure disorder or have experienced a seizure in the past months will be excluded Patients who have a history of head injury or who have known seizure activity History of seizure disorder Patients who have a history of head injury or who have known seizure activity. Uncontrolled seizure disorder Any history of brain metastases or prior seizure or conditions predisposing to seizure activity History of a seizure disorder or requirement for anti-seizure medication Uncontrolled seizure disorder Participant has uncontrolled seizure disorder in past months Patient must not have a seizure disorder Subjects with a history of seizure disorder taking anti-seizure medication within days prior to randomization. medical conditions such as seizure disorder, restless leg disorder, or Parkinson's disease Seizure disorder Documentation of history of seizure within previous years Known history of epilepsy/seizure disorder Patients with prior seizure history who have experienced a seizure within the three months prior to enrollment are excluded History of epileptic disorder or any seizure history unrelated to tumor Huntingtons disease, hydrocephalus or seizure disorder Seizure disorder