Calculated creatinine clearance of > mL/min using the Cockcroft-Gault formula, must be obtained within weeks prior to screening for protocol therapy ELIGIBILITY CRITERIA FOR RANDOMIZATION (STEP ): Calculated creatinine clearance of > mL/min using the Cockcroft-Gault formula Calculated creatinine clearance must be > ml/min using the Cockcroft-Gault formula within weeks prior to randomization Calculated creatinine clearance >= mL/min (Cockcroft-Gault formula) Calculated creatinine clearance >= mL/min (per the Cockcroft-Gault formula) Obtained =< days prior to registration: Calculated creatinine clearance >= ml/min using the Cockcroft-Gault formula Estimated creatinine clearance >= cc/min (calculated by Cockcroft-Gault formula) Creatinine clearance > ml/min calculated by the Cockcroft-Gault formula Calculated creatinine clearance ? mL/min (Cockcroft-Gault formula) Calculated creatinine clearance > mL/min (per the Cockcroft-Gault formula) Calculated creatinine clearance >= ml/min using the Cockcroft-Gault formula Calculated creatinine clearance (using Cockcroft-Gault formula) > mL/min, at the screening visit Calculated creatinine clearance >= mL/min using Cockcroft-Gault formula Creatinine clearance >= mL/min (calculated using the Cockcroft-Gault formula), =< days prior to CD Calculated creatinine clearance >= mL/min using the Cockcroft-Gault formula obtained within days prior to initiating study treatment. Calculated creatinine clearance >= mL/min (Cockcroft-Gault formula) Calculated creatinine clearance > mL/min as determined by Cockcroft-Gault (using actual body weight). Obtained within days prior to registration: Calculated creatinine clearance >= but =< mL/min (Cockcroft-Gault) Estimated creatinine clearance (eClCR) > mL/min (with eCLCR to be calculated by the Cockcroft-Gault formula, or (** = calculated by Cockcroft and Gault's formula) Within days prior to administration of study treatment: Creatinine clearance >= mL/min, calculated using Cockcroft-Gault formula Calculated creatinine clearance > cc/min by the modified Cockcroft-Gault formula for adults or the Schwartz formula for pediatrics Obtained =< days prior to registration: Calculated creatinine clearance must be >= ml/min using the Cockcroft-Gault formula Calculated creatinine clearance of >= cc/min using the Cockcroft-Gault formula Estimated creatinine clearance >= ml/min (calculated according using CockcroftGault formula) Estimated creatinine clearance of < mL/min, calculated using the formula of Cockcroft and Gault at the time of screening Calculated creatinine clearance >= ml/min (using Cockcroft-Gault method) Within days prior to cycle day of treatment: Serum creatinine < . or >= cc/min using a direct method or the Cockcroft-Gault formula Creatinine clearance > mL/min (calculated according to institutional standards or using CockcroftGault formula) Calculated creatinine clearance must be >= ml/min using the Cockcroft-Gault formula obtained =< days prior to registration Serum creatinine clearance >= ml/min (calculated with Cockcroft-Gault formula) Obtained =< days prior to randomization: Calculated creatinine clearance must be >= ml/min using the Cockcroft-Gault formula Calculated creatinine clearance >= mL/min; Cockcroft-Gault formula will be used to calculate\r\ncreatinine clearance PHASE I: Subjects must have calculated creatinine clearance >= ml/min by Cockcroft-Gault formula, obtained =< days prior to registration PHASE II: Subjects must have calculated creatinine clearance >= ml/min by Cockcroft-Gault formula, obtained =< days prior to registration Within days prior to study entry: Calculated creatinine clearance >= mL/min using Cockcroft-Gault formula Calculated creatinine clearance must be >= ml/min using the Cockcroft-Gault formula hour creatinine clearance or calculated (using the Cockcroft-Gault formula) creatinine clearance > mL/min/. m^ (induction phase only) RESEARCH PHASE INCLUSION CRITERIA: hour creatinine clearance or calculated (using the Cockcroft-Gault formula) creatinine clearance > mL/min/. m^ (induction phase only) Creatinine clearance > mL/min (calculated according to institutional standards or using CockcroftGault formula; subjects with requirement of hemodialysis will be excluded) Calculated creatinine clearance >= mL/min (calculated by the Cockcroft-Gault formula), obtained within days of study registration, or PART : Calculated creatinine clearance using the Cockcroft-Gault formula or hr urine creatinine clearance must be > ml/min Within days prior to CD: Estimated creatinine clearance of >= mL/min, calculated using the formula of Cockcroft and Gault Creatinine clearance < mL/min (calculated by Cockcroft-Gault formula) Serum creatinine clearance equal or more than ml/min (calculated with Cockcroft-Gault formula) Calculated creatinine clearance by Cockcroft-Gault formula >= ml/min obtained within weeks prior to registration Patients enrolled in the dose escalation phase who are not enrolled on the expansion cohorts must have calculated creatinine clearance >= ml/min by Cockcroft-Gault formula; patients enrolled in the dose expansion phase must have calculated creatinine clearance >= ml/min by Cockcroft-Gault formula, without use of growth factor support for week Calculated creatinine clearance of >= cc/min using the Cockcroft-Gault formula Creatinine clearance (calculated using Cockcroft-Gault formula, or measured) < mL/min Estimated creatinine clearance of >= mL/min, calculated using the formula of Cockcroft and Gault Calculated creatinine clearance of >= cc/min using the Cockcroft-Gault formula Creatinine clearance > mL/min (calculated using the Cockcroft-Gault formula) or by -hours urine collection Obtained ? days prior to registration: calculated creatinine clearance must be ? ml/min using the Cockcroft Gault formula Calculated creatinine clearance must be >= ml/min using the Cockcroft-Gault formula Creatinine Clearance >= mg/mL as calculated by the modified Cockraft-Gault formula Calculated creatinine clearance must be >= ml/min using the Cockcroft-Gault formula, obtained =< days prior to registration Creatinine clearance > cc/min calculated using the Cockcroft and Gault () formula or measured Estimated creatinine clearance of >= mL/min, calculated using the formula of Cockcroft and Gault Calculated creatinine clearance >= mL/min (Cockcroft-Gault formula) Subjects must have calculated creatinine clearance >= ml/min by Cockcroft-Gault formula Creatinine clearance > ml/min calculated by modified Cockcroft-Gault formula Creatinine clearance >= mL/min\r\n* To be calculated by modified Cockcroft-Gault formula Calculated creatinine clearance must be >= ml/min using the Cockcroft-Gault formula obtained =< days prior to registration (** = calculated by Cockcroft and Gault's formula) Creatinine clearance >= mL/min as calculated by Cockcroft-Gault formula within weeks of pre-registration Calculated creatinine clearance must be >= ml/min using the Cockcroft-Gault formula or a hour urine obtained =< days prior to randomization Creatinine clearance > ml/min calculated by modified Cockcroft-Gault formula Creatinine clearance > mL/min (calculated according to Cockcroft - Gault formula) unless due to lymphoma with documentation of normal function prior to onset of lymphoma Creatinine clearance > cc/min calculated using the Cockcroft and Gault () formula or measured Creatinine clearance > ml/min, calculated using the formula of Cockcroft and Gault Phase Ib subjects must have calculated creatinine clearance >= ml/min by Cockcroft-Gault formula, phase IIa subjects must have calculated creatinine clearance >= ml/min by Cockcroft-Gault formula Creatinine clearance greater than or equal to mL/min to less than ml/min (calculated by Cockcroft-Gault formula) Creatinine clearance > mL/min (calculated according to institutional standards or using CockcroftGault formula; subjects with requirement of hemodialysis will be excluded) Calculated creatinine clearance must be >= ml/min using the Cockcroft-Gault formula Calculated creatinine clearance of >= ml/min; as per Cockcroft-Gault formula Creatine clearance < mL/min according to Cockcroft-Gault formula. If creatine clearance calculated from the -hour urine sample is ? mL/min, patient will qualify for the study Creatinine clearance < mL/min (either actual or calculated value), at time of screening evaluation; the Cockcroft-Gault formula should be used for calculating creatinine clearance values Calculated creatinine clearance must be > ml/min using the Cockcroft-Gault formula Creatinine clearance of ? mL/min (measured or calculated using the Cockcroft and Gault formula) Renal function assessed by calculated creatinine clearance as follows:\r\n* Phase Ib subjects must have calculated creatinine clearance >= mL/min by Cockcroft-Gault formula\r\n* Phase IIa subjects must have calculated creatinine clearance >= mL/min by Cockcroft-Gault formula Calculated creatinine clearance ? ml/min by Cockcroft-Gault formula Total bilirubin < = x ULN Calculated creatinine clearance >= ml/min; for adults this will be calculated per the Cockgroft-Gault formula and in pediatric cases this will be calculated per the Schwartz formula Calculated creatinine clearance >= mL/min calculated by the Cockcroft-Gault formula Calculated creatinine clearance > ml/min using Cockcroft-Gault formula Calculated creatinine clearance (Cockcroft-Gault formula) of >= mL/min Creatinine clearance >/= milliliters per minute (mL/min) (calculated using the Cockcroft-Gault formula) Creatinine clearance > mL/min (calculated according to institutional standards or using CockcroftGault formula), +/- days from date of ICF signing Calculated creatinine clearance must be >= ml/min using the Cockcroft-Gault formula Calculated creatinine clearance must be >= ml/min using the applicable Cockcroft-Gault formula Renal function assessed by calculated creatinine clearance as follows:\r\n* Subjects must have calculated creatinine clearance >= ml/min by Cockcroft-Gault formula (Phase I)\r\n* Subjects must have calculated creatinine clearance >= ml/min by Cockcroft-Gault formula (Phase II) Calculated creatinine clearance >= ml/min by Cockcroft-Gault formula Calculated creatinine clearance ? mL using the Cockcroft and Gault Method Calculated creatinine clearance >= ml/min by Cockcroft-Gault formula Renal impairment as determined by a creatinine clearance < ml/min as calculated by the Cockcroft-Gault formula using the patient's actual weight Creatinine clearance ml/min or higher calculated using the Cockcroft-Gault formula Creatinine clearance >= mL/min calculated using the Cockcroft-Gault formula (within four weeks prior to the study) Calculated (e.g. using Cockcroft-Gault formula) or measured creatinine clearance < ml/min Estimated creatinine clearance of >= mL/min, calculated using the formula of Cockcroft and Gault Calculated creatinine clearance >= ml/min by Cockcroft-Gault formula using actual body weight Calculated creatinine clearance >= mL/min using the Cockcroft-Gault formula Calculated (calc.) creatinine clearance >= mL/min calculated using the Cockcroft-Gault formula Calculated creatinine clearance > ml/min using Cockcroft-Gault method Obtained =< days prior to randomization: Calculated creatinine clearance must be >= ml/min using the Cockcroft-Gault formula Calculated creatinine clearance >= ml/min by Cockcroft-Gault formula Calculated creatinine clearance must be >= ml/min using the Cockcroft-Gault formula obtained =< days prior to registration Calculated creatinine clearance > cc/min by the modified Cockcroft-Gault formula Calculated creatinine clearance >= mL/min (Cockcroft-Gault formula) Calculated creatinine clearance >= mL/min using the Calvert Formula Calculated/estimated or measured creatinine clearance at least ml/min; note: creatinine clearance should be calculated using the Cockcroft-Gault formula; patients who will receive pemetrexed/cisplatin therapy must be obtained within weeks of registration