Patients must have castrate serum level of testosterone of < ng/dL (< . nmol/L) Evidence of castrate testosterone level < ng/dL (or surgical castration) Progressive metastatic prostate cancer despite castrate levels of testosterone (< ng/dL) Surgically or medically castrated, with testosterone ? ng/dL (? . nmol/L). castrate serum level of testosterone of ? ng/dL (? . mmol/L) Non-castrate testosterone level, > ng/dl, at study enrollment Documented castrate level of serum testosterone (< ng/dl) Patients must have castrate levels of testosterone (< ng/dL [. nmol/L]). Castrate testosterone level (< ng/dl or .nmol /L); (patients with a malignancy other than prostate cancer are excluded from this criterion) Castrate testosterone level (< ng/dl or .nmol /L) Castrate testosterone level (< ng/dl or .nmol /L) Metastatic castration resistant prostate cancer with castrate-level testosterone (< ng/dL)\r\n* Subjects must maintain a castrate-level testosterone during the study Tumor progression while on hormone therapy with castrate levels serum testosterone (=< . nmol/L or ng/dL) defined by prostate-specific antigen (PSA) and/or radiographic criteria according to the Prostate Cancer Working Group (PCWG). Castrate levels of testosterone must be maintained by surgical or medical means throughout the conduct of the study. Serum testosterone ? . nmol/L ( ng/dL) at screening. Has a serum testosterone at the Screening visit of ? ng/dL (. nmol/L); Castrate testosterone level (< ng/dl or . nmol/L) mCRPC EXPANSION COHORT: Patients must have castrate levels of testosterone (< ng/dl [. nmol/l]) Documented castrate level of serum testosterone (< ng/dl) Castrate level of testosterone (< ng/dL) Patient must be treated with continuous androgen ablative therapy (e.g. goserelin, leuprolide, triptorelin, or degarelix, if he has not had prior surgical castration) and have castrate levels of testosterone (< ng/dL or . nmol/L) Serum testosterone ? ng/dL (. nmol/L). Testosterone ? ng/dL (? . nmol/L) at screening; Patients must have prior and/or ongoing androgen-deprivation therapy and a castrate level of serum testosterone (< ng/dL). Patients must have a castrate level of serum testosterone (< ng/dL) Testosterone ? . nmol/L (? ng/dL) at screening; Patients must have castrate levels of testosterone (< ng/dl [. nmol/l]). Tumor progression while on hormone therapy with castrate levels serum testosterone (=< . nmol/L or ng/dL) defined as biopsy-proven, PSA and/or radiographic criteria according to the Prostate Cancer Working Group (PCWG); castrate levels of testosterone must be maintained by surgical or medical means throughout the conduct of the study Castrate levels of serum testosterone < ng/dL determined within weeks prior to starting treatment Medical or surgical castration with testosterone less than ng/dL (.nmol/L). Serum testosterone level: ? ng/dL (. nmol/L) Patients must have non-castrate levels of serum testosterone (>= ng/dL) Testosterone =< ng/dL (. nmol/L) Maintain castrate levels of testosterone within weeks prior to randomization and throughout the study Castrate testosterone level (< ng/dl or . nmol/L) Castrate serum testosterone level, =< . nmol/L ( ng/dL), at the screening visit For cohorts , , and only: non-castrate testosterone level (> ng/dL) Castrate levels of serum testosterone of less than or equal to ng/dL Hormone-sensitive prostate cancer as evident by a serum total testosterone level > ng/dL or > nmol/L at the time of enrollment within weeks prior to randomization Testosterone ? . nmol/L (? ng/dL) at screening. Castrate serum testosterone (< ng/dL) Castrate resistant progression of prostate carcinoma, as shown by:\r\n* Serum testosterone level =< ng/dL or prior bilateral orchiectomy; treatment to remain castrate levels of testosterone should continue, and\r\n* Either symptomatic progression, or, if patient is asymptomatic then a rising serum PSA in two occasions at least week apart, with minimum pre-treatment serum PSA of ng/dL Both measurements are greater than ng/dL or . nmol/L; Castrate serum testosterone level: =< ng/dL (=< . nmol/L) Serum total testosterone >= ng/dL (. nmol/L)