Patients with a history of bleeding diathesis are ineligible History of bleeding diathesis or clinically significant bleeding within days prior to randomization. History of hemolytic anemia or bleeding diathesis PHASE II: History of bleeding diathesis; patients receiving anti-coagulation must be able safely interrupt treatment for tumor biopsy Known hemorrhagic diathesis or active bleeding disorder Subjects may not have a history of bleeding diathesis or abnormal sensitivity to ionizing radiation Patients with an active, bleeding diathesis or on oral anti-vitamin K medication (except low dose coumarin) Vascular abnormalities or bleeding diathesis that indicates hepatic artery catheterization is contraindicated Recent or active bleeding diathesis or arterial vascular event within weeks History of hemolytic anemia or bleeding diathesis or positive direct antiglobulin test. Requires therapeutic anticoagulation or has known active bleeding diathesis Contraindication for ibrutinib use because of a bleeding diathesis. Normal coagulation profile and no history of substantial non-iatrogenic bleeding diathesis Inability to tolerate aspirin, or other forms of anticoagulation, due to bleeding diathesis History of bleeding diathesis Patients must have normal coagulation profile and no history of substantial non-iatrogenic bleeding diathesis. Any evidence of bleeding diathesis (patients on therapeutic warfarin or heparin will be excluded) Known history of bleeding diathesis Evidence or history of bleeding diathesis Patient on anticoagulation or with bleeding diathesis due to risk of hematomas at injection site Known abnormalities in coagulation such as bleeding diathesis, or treatment with anticoagulants precluding intramuscular injections of fulvestrant or goserelin (if applicable) For patients undergoing serial tumor biopsies, known bleeding diathesis or history of abnormal bleeding or require anti-coagulation therapy which cannot be interrupted for biopsy PHASE II DOSE EXPANSION IN RECURRENT GBM UNDERGOING RESECTION: Evidence of bleeding diathesis or use of anticoagulant medication or any medication that may increase the risk of bleeding that cannot be stopped prior to surgery Evidence or history of bleeding diathesis Personal or family history of bleeding diathesis and a coagulation profile that would preclude patient from undergoing a neurosurgical procedure History of bleeding disorder or diathesis Presence of bleeding diathesis Evidence of uncontrollable bleeding diathesis Evidence of bleeding diathesis or use of anticoagulant medication or any medication that may increase the risk of bleeding that cannot be stopped prior to surgery Bleeding diathesis, not correctable by usual forms of therapy Bleeding diathesis, not correctable by usual forms of therapy Haemorrhagic diathesis (i.e. haemophilia) Known abnormalities in coagulation such as bleeding diathesis, or treatment with anticoagulants precluding intramuscular injections of fulvestrant or goserelin (if applicable). Subjects with known bleeding diathesis will be excluded from the study. Patients with history of bleeding diathesis are ineligible Subjects with history of bleeding diathesis Known hemorrhagic diathesis or active bleeding disorder History of bleeding diathesis. Known history of a bleeding diathesis. History of congenital bleeding diathesis Evidence of bleeding diathesis or clinically significant bleeding, within days of CD or history of hemoptysis of > . mL/ teaspoon within months of CD Patients with history of bleeding diathesis History of hemolytic anemia or bleeding diathesis In the opinion of the investigator, bleeding diathesis or anticoagulation therapy that would preclude intramuscular injections Evidence of history of bleeding diathesis. Patients with evidence or history of any bleeding diathesis, irrespective of severity Bleeding diathesis or use of warfarin or other vitamin K antagonist History of bleeding diathesis History of bleeding diathesis or extensive bleeding requiring blood transfusion within days of enrollment Contraindications to seed placement, including uncontrollable bleeding diathesis Patients with an active, bleeding diathesis or on oral anti-vitamin K medication (except low-dose warfarin and aspirin or equivalent, as long as the INR =< .) Known bleeding diathesis Patients taking anticoagulants or with a history of a bleeding diathesis Have evidence or history of any bleeding diathesis (including mild hemophilia), irrespective of severity. Evidence of a bleeding diathesis that cannot be corrected with standard therapy or factor replacement History of bleeding diathesis or known qualitative platelet defect (including von Willebrand disease) Known bleeding diathesis or hemophilia History of bleeding diathesis, known factor X deficiency (level < %), or requirement for therapeutic anticoagulation with warfarin Known bleeding diathesis. For patients undergoing serial tumor biopsies, known bleeding diathesis or history of abnormal bleeding or require anti-coagulation therapy. No history of bleeding diathesis. History of bleeding diathesis History of bleeding diathesis Known bleeding diathesis Patients with evidence of a bleeding diathesis that cannot be corrected with standard therapy or factor replacement for intratumoral cohort, bleeding diathesis or use of anticoagulants/antiplatelet agents that cannot be stopped No known bleeding diathesis Known bleeding or thrombotic diathesis Bleeding diathesis or inability to hold anticoagulation for surgery Has known bleeding diathesis that would be a safety risk; Non-correctable bleeding diathesis Familial bleeding diathesis Known bleeding diathesis History of a bleeding diathesis or current anticoagulant therapy Patients with or with a history of uncontrolled bleeding diathesis Patients with an active bleeding diathesis or on oral anti-vitamin K medication (except low-dose warfarin used for catheter-related thrombosis prophylaxis) No history of bleeding diathesis Known bleeding diathesis or history of abnormal bleeding, or any other known coagulation abnormalities that would contraindicate the tumor biopsy procedure. Known bleeding diathesis or history of abnormal bleeding, or any other known coagulation abnormalities that would contraindicate the tumor biopsy procedure.