Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) <  times upper limit of normal (ULN); obtained within  days prior to study entry
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . times institutional upper limit of normal with or without liver metastasis, within  days prior to study entry
Alanine aminotransferase (ALT), aspartate aminotransferase (AST) no greater than . times the upper limit of normal
Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< . times the upper limit of normal
alanine aminotransferase (ALT) and aspartate aminotransferase (AST) <  times upper limit of normal as per local laboratory. Additional inclusion required for donor arm participants to proceed with transplant
Serum aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =<  times the upper limit of normal
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =<  times the upper limit of normal (unless clinically considered to be related to liver involvement with leukemia)
Have an alanine aminotransferase (ALT) and aspartate aminotransferase (AST) level ? times upper limit of normal (ULN)
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . times the upper limit of normal; for patients with documented liver metastases, AST/ALT =< . times the upper limit of normal
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . times the upper limit of normal
TREATMENT INCLUSION: Aspartate aminotransferase (AST)  times or less than the upper limit of normal
Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels ? . times upper limit of normal (ULN)
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < . times the upper limit of institutional normal (ULN)
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) < . times upper limit of normal (ULN)
Clinically significant hepatic dysfunction (alanine or aspartate aminotransferase >  times the upper limit of normal)
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < . times upper limit of normal
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) less than . times the upper limit of normal
AST (aspartate aminotransferase) and ALT (alanine aminotransferase) <  times upper limit of normal (ULN)
Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) > . times the upper limit of normal at the screening visit
Aspartate aminotransferase (AST) ?  times the upper limit of normal
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to . times the upper limit of normal
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) less or equal to . times the upper limit of normal
Aspartate and alanine aminotransferase (AST or ALT) =<  times the upper limit of the reference range
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) less than five times the upper limit of normal
TREATMENT WITH SJCAR: Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =<  times the upper limit of normal for age
Aspartate aminotransferase (AST), alanine aminotransferase (ALT) =<  times upper limit of normal (ULN)
Hepatic impairment as defined by alanine transaminase (ALT) or aspartate aminotransferase (AST) levels greater than  times the upper limit of normal
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) less than five times the upper limit of normal
Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) > . times the upper limit of normal at the screening visit
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . times upper limit of normal (within  days before starting therapy)
Liver transaminases (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) greater than  times the upper limit of normal
Serum alanine aminotransferase (ALT)/alanine aminotransferase (AST) =< to . times the upper limit of normal
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =<  times the upper limit of normal; for patients with documented liver metastases, AST/ALT =< . times the upper limit of normal
Patients must have normal hepatic function (bilirubin, aspartate aminotransferase [AST] and alanine aminotransferase [ALT] <  times the upper limit of normal)
Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) within  times the upper limit of normal and a total serum bilirubin of less than  times the upper limit of normal, both of which define the upper limit of grade  treatment related toxicities
Aspartate aminotransferase (AST) greater than . times the upper limit of normal
Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) less or equal to  times the upper limit of the institutional normal unless liver involvement by malignancy is demonstrated
Obtained =<  days prior to registration: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =<  times upper limit of normal (ULN)
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =<  times upper limit normal
Serum alanine aminotransferase or aspartate aminotransferase <  times the upper limit of normal (ULN)
Aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) >  times the upper limit of normal
Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase <  times upper limit of laboratory normal
Aspartate aminotransferase (ALT)/alanine aminotransferase (AST) =< . times the upper limit of normal
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< . times the upper limit of normal
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . times the upper limit of normal if no liver involvement or =<  times the upper limit of normal with liver involvement
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to . times the upper limit of normal
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< . times the upper limit of normal
Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =<  times the upper limit of normal for age
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to . times the upper limit of normal
Alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< . times the upper limit of normal
Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) less or equal to  times the upper limit of the institutional normal unless liver involvement by malignancy is demonstrated
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to . times the upper limit of normal
Aspartate aminotransferase (AST) of =<  times upper limit of normal
Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) values less than or equal to . times the upper limit of normal; patients with elevations of ALT or AST up to  times the upper limit of normal may be considered for participation if such elevations are thought to be due to liver involvement by malignancy; however, in these latter patients, if AST/ALT do not decrease to less than or equal to . times the upper limit of normal after induction chemotherapy, eligibility for the transplant (research) phase will be at the discretion of the PI
Aspartate aminotransferase (AST) < . times upper limit of normal, performed within  days prior to registration
Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) <  times the upper limit of normal
Aspartate aminotransferase (AST) <  times the upper limit of normal
Serum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) >  times the upper limit of normal
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to . times the upper limit of normal
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to . times the upper limit of normal
Aspartate aminotransferase (AST) /alanine aminotransferase (ALT) =<  times upper limit of normal, unless these are thought to be due to AML
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) >  times upper limit of normal (UNL)
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) are equal or greater than  times the upper limit of normal (ULN)
Aspartate aminotransferase (AST) <  times the upper limit of normal
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to . times the upper limit of normal
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< . times the upper limit of normal in the absence of a history of Gilbert's disease (or pattern consistent with Gilberts), within  days prior to starting therapy
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =<  times the upper limit of normal
RECIPIENT: Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =<  times upper limit of normal
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < . times upper limit of normal
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) <  times the upper limit of normal
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < . times upper limit of normal
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) < . times normal
Aspartate aminotransferase (AST), alanine aminotransferase (ALT) =< . times upper limit of normal (ULN)
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< . times the upper limit of normal (ULN)
Have an alanine aminotransferase (ALT)/aspartate aminotransferase (AST) level ? times upper limit of normal (ULN)
Patients with alanine aminotransferase (ALT)/aspartate aminotransferase (AST) >  times upper limit of normal unless felt to be related the underlying leukemia by the treating physician or hemolysis or Gilbert's disease
Aspartate aminotransferase (AST)  times or less than the upper limit of normal
Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =<  times upper limit of normal
Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) values >= . times the upper limit of normal based on age-specific normal values; if the abnormal liver function is attributable to liver involvement by malignancy, patients may be eligible with serum ALT and AST values up to . times the upper limit of normal, provided the patient has no evidence of impending hepatic failure (encephalopathy or prothrombin time >  times the upper limit of normal)
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < . times upper limit of normal
Aspartate aminotransferase (AST), alanine aminotransferase (ALT) must be no more than . times upper limit of normal unless due to disease involvement of the liver
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to . times the upper limit of normal
Aspartate aminotransferase (AST) < . times upper limit of normal
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) <  times upper limit of normal
Within  days prior to step  registration: Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< . times institutional upper limit of normal
Aspartate aminotransferase (AST), alanine aminotransferase (ALT) <  times upper limit of institutional normal
Serum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) <  times the upper limit of normal
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =<  times institutional upper normal level (AST and ALT =<  times institutional upper normal level, if there is evidence of liver metastasis)
AST (aspartate aminotransferase) and ALT (alanine aminotransferase) <  times upper limit of normal (ULN)
Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) less or equal to . times the upper limit of the institutional normal
Serum aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =<  times the upper limit of normal (ULN) within  days prior to admission
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =<  times institutional upper limit of normal (IULN)
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < . times upper limit of normal
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) <  times the institutional upper limit of normal
Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) within  times the upper limit of normal
Aspartate aminotransferase (AST) less than  times the upper limit of normal
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to . times the upper limit of normal
Aspartate aminotransferase (AST) < . times upper limit of normal
Aspartate aminotransferase (AST) =< . times upper limit of normal
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =<  times upper limit of normal (ULN)
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) must each be =< -times the upper limits of normal (ULN) or =< -times normal if due to ATL
Aspartate aminotransferase (AST) less than  times the upper limit of normal
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) less than  times the upper limit of normal
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =<  times upper limit of normal
Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . times upper limit of normal; values above these levels may be accepted, at the discretion of the PI or LAI, if such elevations are thought to be due to liver involvement by malignancy or GVHD
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) = < . times upper limit of normal
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . times upper limit of normal
Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =<  times the upper limit of normal
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . times upper limit of normal
Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) less than three times the upper limit of normal
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . times the upper limit of normal
Aspartate aminotransferase (AST) =< . times the UIHC upper limit of normal
Aspartate aminotransferase (AST)  times or less than the upper limit of normal
Have adequate hepatic function (bilirubin, aspartate aminotransferase (AST), and alanine aminotransferase (ALT), defined as ?  times the upper limit of normal [ULN])
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . times upper limit of normal (within  days before starting therapy)
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . times the upper limit of normal (ULN)
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) > . times the upper limit of normal
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < . times upper limit of normal
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . times the upper limit of normal
Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) > . times the upper limit of normal
Serum alanine aminotransferase or aspartate aminotransferase <  times upper limit of normal (ULN)
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) >= . times upper level of normal (ULN)
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =<  times the upper limit of normal
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . times the institutional upper limit of normal within  weeks of enrollment
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . times institutional upper limit of normal or =<  times institutional upper limit of normal in the presence of liver metastases
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . times institutional upper limit of normal or =< . times institutional upper limit of normal in the presence of liver metastases
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . times upper limit of normal (within  days before starting therapy)
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) <  times normal
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =<  times the institutional upper limit of normal
Patients must have the following screening results for hepatic function according to MD Anderson testing standards: total bilirubin < . times the upper limit of normal; alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST - if available) must be <  times the upper limit of normal
Alanine aminotransferase (ALT) and aspartate transaminase (AST) less than or equal to  times the upper limit of the institution-established normal range
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to . times the upper limit of normal
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . times upper limit of normal
Aspartate aminotransferase (AST) and alanine transaminase (ALT) <  times the upper limit of normal
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =<  times the upper limit of normal (ULN)
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) less than or equal to  times the upper limit of normal
Liver transaminases (aspartate aminotransferase [AST], alanine aminotransferase [ALT]) less than  times the upper limit of normal (unless due to active myositis)
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) <  times the upper limit of laboratory normal
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) <  times the upper limit of normal
Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) values less than or equal to . times the upper limit of normal; patients with elevations of ALT or AST up to  times the upper limit of normal may be considered for participation if such elevations are thought to be due to liver involvement by malignancy; however, in these latter patients, if these values do not decrease to less than or equal to . times the upper limit of normal during induction chemotherapy, such patients will not be eligible for the transplant phase of the protocol, and will thus be taken off study
Aspartate aminotransferase (AST) =<  times upper limit of normal
Alanine aminotransferase (ALT), aspartate aminotransferase (AST) less than . times the upper limit of normal without evidence of active infectious hepatitis
Aspartate aminotransferase and/or alanine transaminase > times upper limit of normal.
Total bilirubin or alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ? . times upper limit of normal (ULN) at screening.
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) >  times the upper limit of normal
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . times the upper limit of normal unless hepatic dysfunction is related to liver involvement with disease
Aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) <  times the upper limit of normal (ULN)
Aspartate aminotransferase or alanine aminotransferase >  times the upper limit of normal.
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< . times the upper limit of normal (ULN)
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to . times the upper limit of normal
Alanine aminotransferase (ALT), aspartate aminotransferase (AST) < . times the upper limit of normal; in patients with liver metastasis, liver function tests should be <  times the upper limit of normal
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to . times the upper limit of normal
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . times upper limit of normal (ULN)
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) <  times upper limit of normal
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) less or equal to . times the upper limit of normal
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) less than or equal to  times the upper limit of the institution-established normal range
Aspartate aminotransferase (AST) <  times the upper limit of normal
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) >= . times the upper limit of normal
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to . times the upper limit of normal
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =<  times institutional upper normal level (AST and ALT =<  times institutional upper normal level, if there is evidence of liver metastasis)
Transaminases (aspartate aminotransferase [AST], alanine aminotransferase [ALT]) <  times upper limit of normal values
Total bilirubin (TBL), alanine aminotransferase (ALT) or aspartate aminotransferase (AST) > . times the upper limit of normal
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to . times the upper limit of normal
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) less than three times the upper limit of normal
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . times the upper limit of normal if no liver involvement or =<  times the upper limit of normal with liver involvement
Serum total bilirubin less than . mg/dl, and serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) values less than or equal to . times the upper limit of normal; ALT and AST values above these levels may be accepted (up to a maximum of  times the upper limit of normal), at the discretion of the principal investigator (PI) or study chairperson, if such elevations are thought to be due to liver involvement by malignancy
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < . times upper limit of normal
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to . times the upper limit of normal
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< to . times the upper limit of normal
Patients with history of severe liver disease, defined as and confirmed by elevated alanine aminotransferase\r\n(ALT) and aspartate aminotransferase (AST) greater than . times the upper limit of normal.
Is known or suspected to have significant hepatic dysfunction, with aspartate aminotransferase (AST) & alanine aminotransferase (ALT)  times above upper limit of normal (ULN) per institutional laboratory
Patients with severe hepatic impairment as defined as aspartate aminotransferase (AST)/alanine aminotransferase (ALT) greater than three times the upper limit of normal and/or, total bilirubin greater than  mg/dL, and/or Child-Pugh score > 
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) values greater than  times the upper limit of normal
Serum aspartate aminotransferase (AST) =< . times the upper limit of normal
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) <  times institutional upper limit of normal
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =<  times the upper limit of normal
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) greater than  times the upper limit of normal
The screening results for aspartate aminotransferase (AST), if available, must be <  times the upper limit of normal
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) must be < . times the upper limit of the institutional normal range; test results must be no more than  months old
Alanine aminotransferase (ALT) must be <  times the upper limit of normal; if available, screening results for aspartate aminotransferase (AST) must be <  times the upper limit of normal
Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) lower than three times the upper\r\nlimit of normal
Minocycline trial only: screening results for aspartate aminotransferase (AST) must be <  times the upper limit of normal
Patient with aspartate aminotransferase (AST) or alanine aminotransferase (ALT) three times the upper limit of normal
An aspartate aminotransferase (AST) less than  times the upper limit of normal, unless these values are due to underlying hematologic malignancy
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =<  times the upper normal limit
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) must be <  times the upper limit of normal, as evidenced in laboratory values =<  months old
DONOR: Active liver disease (alanine aminotransferase [ALT] or aspartate aminotransferase [AST] levels >  times the upper limit of normal [ULN])
Subjects with moderate or severe liver dysfunction at baseline, defined as aspartate aminotransferase, alanine aminotransferase, or alkaline phosphatase levels greater than  times the upper limit of normal (ULN)
Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) > . times upper limit of normal (ULN)
Serum aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) >  times upper limit of institutional normal
Transaminases (aspartate aminotransferase [AST], alanine aminotransferase [ALT]) <  times upper limit of normal values
Transaminases (aspartate aminotransferase [AST], alanine aminotransferase [ALT]) <  times upper limit of normal values
Aspartate aminotransferase <  times upper limit of normal value
Transaminases (aspartate aminotransferase [AST], alanine aminotransferase [ALT]) <  times upper limit of normal values
Liver transaminases (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) greater than  times the upper limit of normal
Liver transaminases (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) greater than  times the upper limit of normal
Elevated liver function tests (LFTs) (aspartate aminotransferase [AST], alanine aminotransferase [ALT], alkaline phosphatase [ALP] or bilirubin levels greater than . times the normal limit) from laboratory tests conducted within  days prior to surgery
Liver transaminases (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) greater than  times the upper limit of normal
bilirubin ? . mg/dL; alanine aminotransferase (ALT), aspartate transaminase (AST) ? . times the upper limit of normal if no liver involvement or ?  times the upper limit of normal with liver involvement.