Obtained within days prior to treatment start: Total calcium (CA) (corrected for serum albumin) within normal limits for the institution or corrected to within normal limits with supplements before first dose of study medication Potassium, total calcium (corrected for serum albumin), magnesium, sodium and phosphorus within normal limits for the institution or corrected to within normal limits with supplements before first dose of study medication Potassium, total calcium (corrected for serum albumin), magnesium, and phosphorus within normal limits for the institution or corrected to within normal limits with supplements Potassium, total calcium (corrected for serum albumin), magnesium, and sodium within normal limits for the institution or corrected to within normal limits before first dose of study medication Potassium, sodium, calcium (corrected for serum albumin), magnesium, and phosphorus within normal limits for the institution; Potassium, total calcium (corrected for serum albumin), magnesium, sodium and phosphorus within normal limits for the institution or corrected to within normal limits with supplements before first dose of study medication Patients must have the following laboratory values within the laboratory normal limits or corrected to within normal limits with supplements during screening:\r\n* Potassium\r\n* Magnesium\r\n* Phosphorus\r\n* Total calcium (corrected for serum albumin) Total Ca (corrected for serum albumin) w/in normal limits Patient must have the following laboratory values or have the following laboratory values corrected with supplements to be within normal limits before the first dose of ceritinib + trametinib:\r\n* Potassium\r\n* Magnesium\r\n* Phosphorus\r\n* Total calcium (corrected for serum albumin) Potassium, total calcium (corrected for serum albumin), magnesium, and sodium within normal limits for the institution or corrected to within normal limits with supplements before first dose of study medication Potassium, sodium, and total calcium (corrected only in the case of hypoalbuminemia) within normal limits of the local laboratory (screening values can be rechecked after electrolyte repletion and before the first dose of study medication, if necessary) Potassium, total calcium (corrected for serum albumin), magnesium, sodium and phosphorus within normal limits for the institution or corrected to within normal limits with supplements before first dose of study medication Total calcium (corrected for serum albumin) within normal limits prior to the first dose of study medication Potassium, sodium, calcium corrected for serum albumin and magnesium within normal limits or corrected to within normal limits with supplements before first dose of the study medication Potassium, sodium, magnesium, and calcium (corrected for serum albumin) =< grade or within the institutional ranges of normal; if clinically appropriate, electrolytes may be corrected and values reassessed prior to enrollment (within days prior to registration) Patients must have the following laboratory values or have the following laboratory values corrected to be within normal limits before the first dose of ceritinib:\r\n* Potassium\r\n* Magnesium\r\n* Phosphorus\r\n* Total calcium (corrected for serum albumin) Potassium, total calcium (corrected for serum albumin), magnesium, sodium and phosphorus within normal limits for the institution or corrected to within normal limits with supplements before first dose of study medication CAPMATINIB INCLUSION CRITERIA: Serum potassium, calcium (corrected for serum albumin), magnesium, phosphorus within normal limits with or without supplementation CERITINIB INCLUSION CRITERIA: Serum potassium, calcium (corrected for serum albumin), magnesium, phosphorus within normal limits with or without supplementation REGORAFENIB INCLUSION CRITERIA: Serum potassium, calcium (corrected for serum albumin), magnesium, phosphorus within normal limits with or without supplementation Patient must have the following laboratory values or have the following laboratory values corrected with supplements to be above the lower limit of normal before the first dose of ceritinib:\r\n* Potassium\r\n* Magnesium\r\n* Phosphorus\r\n* Total calcium (corrected for serum albumin) Potassium, Magnesium, Phosphorus, total Calcium (corrected for serum albumin) outside of normal limits (patients may be enrolled if corrected to within normal limits with supplements during screening) . Adequate organ function as defined by the following: \r\na. Serum creatinine =< x the upper limit of normal (ULN), or glomerular filtration rate > ml/hour (h) as calculated by Cockcroft-Gault formula.\r\nb. Serum potassium, magnesium, and calcium (corrected for albumin) within institutional normal limits or can be corrected with supplementation.\r\nc. Total serum bilirubin =< . x ULN.\r\nd. Serum aspartate transaminase (AST) and/or alanine transaminase (ALT) =< . x ULN. Potassium within normal limits for the institution, or corrected with supplements Calcium (corrected for albumin) within normal limits (oral supplementation is allowed) Potassium, total calcium (corrected for serum albumin), magnesium, sodium and phosphorus within normal limits for the institution or corrected to within normal limits with supplements before first dose of study medication Total calcium (corrected for serum albumin if albumin abnormal) above lower limit normal range for the institution; supplementation may be given before the first dose of study medication Within days of subject registration: Potassium, calcium (corrected for serum albumin) and magnesium within IULN Serum potassium, magnesium, and calcium (serum calcium corrected for hypoalbuminemia) within institutional normal limits. Subjects with electrolytes outside the normal range will be eligible if these values are corrected upon retesting following any necessary supplementation. Sodium, potassium, phosphorus, magnesium and total calcium laboratory values within normal limits Patients have the following laboratory values outside of the laboratory normal limits or cannot be corrected to within normal limits with supplements during screening: Potassium, Magnesium, Phosphorus, Total calcium (corrected for serum albumin) Potassium, total calcium (corrected for serum albumin), magnesium, sodium and phosphorus within institutional upper limit of normal (IULN) or corrected to within normal limits with supplements before first dose of study medication; (supplements used for this purpose to be approved by primary investigator [PI]) Potassium and calcium (corrected for albumin), within normal limits for the institution, or =< grade if judged not clinically significant by the investigator Serum potassium (corrected for serum albumin) must be within clinically relevant limits (e.g., a patient can be enrolled if a lab value may be outside the normal laboratory range but the abnormality is not clinically relevant or can be repleted) Sodium (corrected for serum albumin) must be within clinically relevant limits (e.g., a patient can be enrolled if a lab value may be outside the normal laboratory range but the abnormality is not clinically relevant or can be repleted) Magnesium (corrected for serum albumin) must be within clinically relevant limits (e.g., a patient can be enrolled if a lab value may be outside the normal laboratory range but the abnormality is not clinically relevant or can be repleted) Phosphorus (corrected for serum albumin) must be within clinically relevant limits (e.g., a patient can be enrolled if a lab value may be outside the normal laboratory range but the abnormality is not clinically relevant or can be repleted) Total calcium (corrected for serum albumin) must be within clinically relevant limits (e.g., a patient can be enrolled if a lab value may be outside the normal laboratory range but the abnormality is not clinically relevant or can be repleted) Total calcium (corrected for serum albumin) within normal limits Total calcium (corrected for serum albumin) within normal limits or corrected with supplements Potassium, magnesium, and calcium (corrected for albumin) > normal limits for the institution Serum calcium and magnesium within the normal range (or corrected with supplements) Potassium and calcium (corrected for albumin), sodium and magnesium within institutional normal limits Sodium, potassium, phosphorus, magnesium and total calcium laboratory values within normal limits The following laboratory values must be within normal limits prior to starting study drug (supplementation allowed): potassium, magnesium, total calcium (corrected for serum albumin), phosphorous Serum electrolytes within normal limits: potassium, calcium (total, or corrected for serum albumin in case of hypoalbuminemia) and magnesium. If outside of normal limits, subject will be eligible when electrolytes are corrected; Potassium, total calcium (corrected for serum albumin), magnesium, sodium and phosphorus within normal limits for the institution or corrected to within normal limits with supplements before first dose of study medication