Serum creatinine =< . x ULN or creatinine clearance >= mL/min; obtained within days prior to study entry Adequate renal function determined within weeks prior to randomization defined as the most recent serum creatinine =< ULN or measured or calculated creatinine clearance > mL/min Serum creatinine =< . times ULN OR calculated creatinine clearance >= mL/min Re-registration: creatinine =< . ULN OR calc. creatinine clearance > mL/min (using lean body mass formula only) Serum creatinine must be =< x the institutional ULN OR creatinine clearance (either measured or calculated) must be > mL/min; must be obtained within days prior to registration Serum creatinine =< IULN OR measured or calculated creatinine clearance >= mL/min, obtained within days prior to step registration Obtained within days prior randomization: serum creatinine =< . x ULN for the lab or measured or calculated creatinine clearance >= mL/min Serum creatinine =< . ULN OR measured or calculated creatinine clearance >= mL/min creatinine clearance ? mL/min/. m for subjects with serum creatinine levels >. higher than ULN. Renal: serum creatinine within normal limits (WNL), defined as within % of the institution's stated reference range, or a calculated creatinine clearance > mL/min/. m. sq. for patients with abnormal, increased, creatinine levels. Creatinine > . times ULN concurrent with creatinine clearance < ml/min; confirmation of creatinine clearance is only required when creatinine is > . times ULN Serum creatinine > . x ULN and/or creatinine clearance ? mL/min Chemistry Total bilirubin ? mg/dL AST and/or ALT > x ULN Serum creatinine > . x ULN and/or creatinine clearance ? mL/min Creatinine clearance > Ml/min/. m for patients with creatinine levels above ULN calculated using Calvert formula Creatinine =< . x ULN or creatinine clearance > ml/min Within days of study registration: Normal serum creatinine or creatinine clearance >= ml/min/. m^ Serum creatinine ? . X ULN (OR creatinine clearance ? mL/min/. m) Serum creatinine =< . x institutions ULN, or creatinine clearance >= ml/min Creatinine >. times ULN concurrent with creatinine clearance < mL/min Adequate organ function within days of study registration including:\r\n* Normal serum creatinine or creatinine clearance >= ml/min/. m^ Serum creatinine >. x ULN and/or measured creatinine clearance < ml/min Creatinine less than . X ULN and/or creatinine clearance >= mL/min Creatinine < . x ULN OR creatinine clearance > mL/min for subject with creatinine levels > . x ULN Serum creatinine =< IULN OR measured or calculated creatinine clearance >= mL/min Serum Creatinine or Creatinine Clearance** ? . x ULN, > mL/min Renal: Serum creatinine < . x ULN or creatinine clearance ? mL/min/.m^ for patients with serum creatinine levels above x ULN. Creatinine =< . x ULN or calculated creatinine clearance >= mL/min for subject with creatinine ? . x institutional ULN obtained =< days prior to registration Creatinine =< . ULN or calculated creatinine clearance >= ml/min Obtained =< days prior to registration: Creatinine =< . x ULN OR measured or calculated creatinine clearance (per institutional standard) must be >= ml/min Creatinine > or = . x ULN or creatinine clearance < mL/min (calculated). Creatinine =< . ULN OR creatinine clearance >= Ml/min/. m^ for patients with creatinine levels above ULN calculated using Calvert formula Renal: Serum creatinine . x ULN or creatinine clearance mL/min. Creatinine =< . x ULN OR creatinine clearance >= mL/min/. m^ Creatinine =< . x ULN or calculated creatinine clearance >= mL/min for subject with creatinine ? . x institutional ULN obtained =< days prior to registration Serum creatinine > . x ULN for age or creatinine clearance =< mL/min/. m^ Creatinine =< . x ULN OR creatinine clearance >= mL/min/. m^ for participants with creatinine levels above . x ULN Adequate kidney function with serum creatinine < x the ULN or creatinine clearance > mL/min Serum creatinine ? . x ULN or estimated creatinine clearance ? mL/min Serum creatinine =< . x the ULN and calculated creatinine clearance > ml/min Serum creatinine =< . X ULN (OR creatinine clearance >= mL/min/. m^) CERITINIB INCLUSION CRITERIA: Creatinine OR creatinine clearance < . mg/dL >= mL/min (calculated by Cockgraft-Gault) for patients with creatinine levels above ULN REGORAFENIB INCLUSION CRITERIA: Creatinine OR creatinine clearance =< . x ULN; > mL/min (calculated by Cockgraft-Gault) for patients with creatinine levels above ULN Either a serum creatinine ? ULN for age, or calculated or measured GFR ? mL/min/. m Serum creatinine =< . X ULN OR calculated creatinine clearance >= mL/min for patients with creatinine levels > . X institutional ULN Calculated creatinine clearance ? mL/min /. m for subjects with serum creatinine levels > . x institutional ULN Serum creatinine >. x ULN and/or measured or calculated creatinine clearance <% LLN Serum creatinine =< . x ULN OR a measured creatinine clearance or calculated creatinine clearance >= mL/min Serum creatinine within normal range with a creatinine clearance >= ml/min Renal: Serum creatinine < . x ULN or creatinine clearance ? mL/min/.m for patients with serum creatinine levels above . x ULN. Serum creatinine within . x normal range for age OR creatinine clearance with a recommended eGFR ? mL/min/.m^ Serum creatinine within . x normal range for age OR creatinine clearance with a recommended eGFR ? mL/min/.m^ Serum creatinine =< . ULN or creatinine clearance >= mL/min/. m^ Serum creatinine =< ULN for the lab and measured or calculated creatinine clearance > mL/min within days before randomization Serum creatinine < . x ULN or serum creatinine clearance > mL/min Creatinine =< . x ULN and concurrent creatinine clearance (CrCl) >= mL/min/. m^ for patients with creatinine (Cr) > . x ULN Patients must have a serum creatinine limit of =< . ULN or creatinine clearance of >= ml/min measured within days of registration Serum creatinine =< the IULN OR measured or calculated creatinine clearance >= mL/min Patients must have a serum creatinine =< the IULN OR measured or calculated creatinine clearance >= mL/min Serum creatinine =< . ULN or creatinine clearance >= mL/min Within weeks prior to randomization, the most recent serum creatinine must be =< ULN or measured or calculated creatinine clearance must be > mL/min Creatinine =< . X ULN OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels > . x ULN PHASE II: Creatinine =< . X ULN OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels > . x ULN Creatinine =< . times ULN OR measured creatinine clearance of >= mL/min . m^ Obtained within days prior to registration: Serum creatinine =< . x IULN OR measured or calculated creatinine clearance >= mL/min Serum creatinine ? . x ULN; or a creatinine clearance ? mL/min; Serum creatinine ? x ULN or estimated creatinine clearance ? ml/min. Serum creatinine =< IULN OR measured or calculated creatinine clearance >= mL/min be obtained within days prior to registration CLINICAL/LABORATORY CRITERIA: Serum creatinine =< . x IULN OR measured or calculated creatinine clearance >= mL/min; this result must have been obtained within days prior to registration AMKL PATIENTS: Creatinine < . x ULN or calculated creatinine clearance > ml/min MF PATIENTS: Creatinine < . x ULN or calculated creatinine clearance > ml/min Serum creatinine =< ULN within days prior to registration OR calculated creatinine clearance > ml/min; the serum creatinine value used in the calculation must have been obtained within days prior to registration Creatinine =< . x ULN OR calculated or measured creatinine clearance >= mL/min/. m^ for patients with creatinine above institutional normal Renal: Serum creatinine ? . x ULN, or for patients with serum creatinine > . ULN, creatinine clearance ? mL/min. Calculated creatinine clearance > ml/min; the serum creatinine value used in the calculation must have been obtained within days prior to Step Randomization Calculated creatinine clearance > ml/min; the serum creatinine value used in the calculation must have been obtained within days prior to Step registration Participant has serum creatinine ? . x ULN. If serum creatinine > . x ULN the calculated creatinine clearance should be > milliliters/minute (mL/min) Serum Creatinine or Creatinine Clearance** ? . x ULN, > mL/min Serum creatinine ?. times institutional ULN or calculated creatinine clearance > mL/min; Serum creatinine ? . ULN or calculated or measured creatinine clearance ? mL/min/. m Creatinine =< . x ULN or creatinine clearance >= mL/min/. m^ Serum creatinine =< . x ULN or calculated creatinine clearance >= ml/min Creatinine =< ULN or a calculated creatinine clearance of >= ml/min if creatinine is greater than the ULN Has adequate renal function defined as serum creatinine or ? . ULN and creatinine clearance or ? ml/min. Serum creatinine =< . x ULN, or calculated creatinine clearance >= ml/min Pediatric patients must have creatinine clearance >= mL/min/. m^ regardless of serum creatinine level Serum creatinine performed within weeks prior to study entry must be less than or equal to . x ULN or estimated creatinine clearance less than mL/min (as calculated using the method standard for the institutions). Patients must have adequate renal function, defined as serum creatinine ? . x ULN or creatinine clearance (calculated) ? mL/min/. m for patients with creatinine > . x ULN. Serum creatinine =< . x the ULN or calculated creatinine clearance >= ml/min Creatinine =< . times ULN OR measured creatinine clearance > mL/min Renal: serum creatinine (sCr) ?. x ULN, or creatinine clearance (Ccr) ? mL/min. Serum creatinine =< . the institutional ULN; if creatinine is above the ULN, the patient's measured or calculated creatinine clearance (CrCl) must be >= mL/min Creatinine =< . x institutional ULN or creatinine clearance (calculated or measured) > ml/min Normal serum creatinine or creatinine clearance >= ml/min/. m^ Serum creatinine =< . x ULN or calculated creatinine clearance >= mL/min Serum creatinine =< . x ULN or calculated creatinine clearance >= mL/min Serum creatinine ? . ULN according to institutional standards or creatinine clearance ? mL/min Creatinine < . x ULN OR calculated creatinine clearance >= mL/min Creatinine =< . x ULN OR calculated creatinine clearance >= ml/min Creatinine =< . X ULN OR creatinine clearance >= mL/min/. m^ Renal: serum creatinine (sCr) ?. x ULN, or creatinine clearance (Ccr) ? mL/min. Renal: Serum creatinine < . x ULN OR calculated creatinine clearance (CLcr) ? ml/min Serum creatinine < x ULN or creatinine clearance > mL/min Renal: Serum creatinine < ULN OR calculated creatinine clearance (CLcr) of ? ml/min Serum creatinine =< . X ULN and stable X month OR creatinine clearance >= Ml/min/. m^ Serum creatinine < . x ULN or creatinine clearance ? mL/min as measured by institutional standards Serum creatinine >. x ULN or creatinine clearance ? mL/min Serum creatinine =< . x ULN or creatinine clearance >= mL/min Acceptable renal function: Serum creatinine ? . times the ULN, or calculated creatinine clearance ? mL/min/. m for patients with creatinine levels above . times the institutional normal Serum creatinine =< . x ULN or calculated creatinine clearance > mL/min Has adequate organ function: AST and ALT < X the ULN, serum bilirubin < X the ULN, serum creatinine of < mg/dL, or a calculated creatinine clearance of > mL/minute Serum creatinine =< . x ULN or creatinine clearance >= mL/min Creatinine ?. x ULN or Creatinine Clearance ? mL/min Serum creatinine =< . x ULN and creatinine clearance > ml/min Creatinine =< . x ULN OR calculated or measured creatinine clearance >= mL/min/. m^ for patients with creatinine above institutional normal Serum Creatinine ? . x ULN, or Creatinine Clearance > mL/min Creatinine >= . ULN for the institution (or a calculated creatinine clearance < mL/min/. m) Serum creatinine =< . x ULN OR calculated creatinine clearance >= mL/min Serum creatinine > . ULN (or a calculated creatinine clearance < mL/min/. m) Serum creatinine ?. x ULN or creatinine clearance > mL/min/. m^ for subjects with creatinine levels >. x ULN Patients must have a serum creatinine within normal limits, or an estimated or measured creatinine clearance >= ml/min The participant has adequate renal function as defined by serum creatinine ? . x the institutional ULN or creatinine clearance ? milliliter/minute (mL/min) for participants with creatinine levels above the ULN Must have a serum creatinine < . and creatinine clearance > ml/min/m^; other organ dysfunction is eligible at the discretion of the Principal Investigator (PI) Patients must have a calculated creatinine clearance > mL/min; the serum creatinine value used in the calculation must have been obtained within days prior to registration Age-adjusted normal serum creatinine or a creatinine clearance ? ml/min Creatinine > . x ULN or creatinine clearance < mL/min from assays obtained < weeks prior to study enrollment Creatinine > . x ULN or creatinine clearance < mL/min, from assays obtained < weeks prior to study enrollment Creatinine >. x ULN or creatinine clearance < mL/min Creatinine > . x ULN or creatinine clearance < mL/min Creatinine > . x ULN or creatinine clearance < mL/min, from assays obtained < weeks prior to study enrollment Have adequate renal function, defined as serum creatinine levels ?. ULN or calculated creatinine clearance > mL/min. Creatinine ? . x ULN or CrCl > mL/min/. m for patients with serum creatinine levels above institutional . x ULN The participant has adequate renal function as defined by serum creatinine less than or equal to . x the institutional ULN or creatinine clearance greater than or equal to mL/min for participants with creatinine levels above the ULN. The participant has adequate renal function as defined by serum creatinine less than or equal to . x the institutional ULN or creatinine clearance greater than or equal to mL/min for participants with creatinine levels above the ULN. Serum creatinine >. x ULN, or estimated creatinine clearance