Calculated serum creatinine clearance >= mL/min/. m^, within days prior to administration of study treatment STEP I: Calculated creatinine clearance >= mL/min (obtained within days prior to randomization) Calculated creatinine clearance > ml/min within days prior to step randomization Within days of registration: Calculated (calc.) creatinine clearance > mL/min Calculated creatinine clearance (Cr Cl) >= ml/min; eligible for full dose methotrexate Calculated creatinine clearance at least mL/min. Calculated creatinine clearance >= mL/min Calculated creatinine clearance >= mL/min Calculated creatinine clearance > ml/min. Calculated creatinine clearance > mL/min PHASE II INCLUSION CRITERIA: Calculated creatinine clearance > mL/min Normal creatinine for age or a calculated creatinine clearance >= mL/min/. m^ Estimated creatinine clearance >= mL/min as calculated using the method standard for the institution Calculated creatinine clearance >= mL/min Obtained =< days prior to registration and confirmed prior to the first dose of study drug: Calculated creatinine clearance >= mL/min Calculated creatinine clearance > mL/min; Calculated or measured creatinine clearance >= ml/min, obtained =< days prior to registration Calculated creatinine clearance >= ml/min. Renal: Creatinine clearance of ? mL/min, estimated or calculated. Calculated creatinine clearance of >= mL/min Within weeks before enrollment: Calculated creatinine clearance > mL/min Calculated creatinine clearance >= mL/min Serum creatinine clearance of >= ml/min (calculated or measured) Obtained within days prior to enrollment: calculated creatinine clearance > ml/min Patients must have a calculated creatinine clearance of >= Calculated or measured creatinine clearance >= ml/min Obtained =< days prior to registration: Calculated or measured creatinine clearance >= ml/min Calculated creatinine clearance >= mL/min/. m^ Creatinine clearance >= mL/min (measured or calculated per local practice) Calculated or measured creatinine clearance (method determined by the prescribing physicians) < ml/min Creatinine clearance >= mL/min, estimated or calculated Calculated creatinine clearance >= mL/min Calculated creatinine clearance >= mL/min Calculated creatinine clearance >= mL/min Calculated creatinine clearance >= mL/min/. m^ Calculated creatinine clearance >= mL/min Calculated creatinine clearance >= mL/min Calculated creatinine clearance ? mL/min Calculated creatinine clearance >= mL/min Creatinine clearance > ml/min (calculated creatinine clearance is permitted) Calculated creatinine clearance > ml/min Calculated creatinine clearance >= mL/min/. m^ Serum creatinine =< . x ULN or clearance >= mL/min (measured or calculated) Calculated creatinine clearance > ml/min Calculated creatinine clearance ? mL/min. Calculated creatinine clearance of ? ml/min. Calculated Creatinine Clearance of ml/min Calculated creatinine clearance > mL/min. Calculated creatinine clearance >ml/m Calculated creatinine clearance of < mL/min in Stage and < mL/min in Stage Patients with moderate or severe renal impairment (calculated creatinine clearance of < mL/min) ORAL CAVITY SQUAMOUS CELL CARCINOMA COHORT: Calculated creatinine clearance > mL/min Creatinine clearance > ml/min (calculated or measured) Calculated creatinine clearance >= mL/min Estimated creatinine clearance >= ml/min as calculated using the method standard for the institution Calculated creatinine clearance of > mL/min/m^, within days prior to registration. Creatinine clearance (calculated or measured) > mL/min Calculated creatinine clearance >= mL/min Calculated (calc.) creatinine clearance > mL/min Calculated creatinine clearance > mL/min/. m^ Measured or calculated creatinine clearance >= mL/min Calculated creatinine clearance >= mL/min within days of enrollment Calculated or measured creatinine clearance >= ml/min within days prior to registration Creatinine clearance (calculated or hour) >= ml/min Calculated creatinine clearance >= mL/min Calculated creatinine clearance ? mL/min/.m^ Calculated creatinine clearance >= mL/min within four weeks prior to randomization Calculated creatinine clearance ? mL/min Calculated Creatinine clearance>/= ml/min Calculated creatinine clearance >= ml/min Measured or calculated creatinine clearance >= ml/min Calculated creatinine clearance > mL/min Calculated or measured creatinine clearance ? mL/min An average calculated creatinine clearance > mL/min/. m^ Calculated creatinine clearance > ml/min Calculated creatinine clearance > mL/min Calculated creatinine clearance >= mL/min Creatinine clearance of >= mL/min, estimated or calculated Calculated creatinine clearance >= mL/min Calculated creatinine clearance >= mL/min Calculated creatinine clearance >= mL/min Calculated creatinine clearance >= mL/min Calculated creatinine clearance > ml/min Calculated creatinine clearance of ? mL/min Calculated creatinine clearance ? mL/min. Calculated creatinine clearance > ml/min Children (< years old): calculated creatinine clearance must be > mL/min Calculated creatinine (calc. creat.) clearance >= ml/min Creatinine clearance (calculated creatinine clearance is permitted) should be > ml/min If > . mg/dL, calculated creatinine clearance >= mL/min Creatinine clearance >= ml/mm (can be calculated) Calculated creatinine clearance > mL/min/. m^ Calculated creatinine clearance >= ml/min Subjects must have calculated creatinine clearance >= ml/min Calculated creatinine clearance >= mL/min Calculated creatinine clearance >= mL/min Calculated creatinine clearance >= mL/min Urothelial cancer patients should be ineligible for cisplatin based on one or more of the following:\r\n* Calculated creatinine clearance of < mL/min (but >= mL/min)\r\n* Solitary kidney\r\n* Karnofsky performance status < % Calculated creatinine clearance of ? ml/min. Creatinine clearance equal or > ml/min (calculated) Creatinine clearance < ml/min (calculated) Calculated or measured creatinine clearance >= mL/min Calculated creatinine clearance >= mL/min Calculated creatinine clearance > ml/min (unless demonstrated Hodgkin lymphoma involvement of the kidney) Calculated creatinine clearance >= mL/min Calculated creatinine clearance > mL/min. Calculated creatinine clearance > mL/min. Calculated creatinine clearance > mL/min per institutional standard Calculated or measured creatinine clearance >= mL/min Calculated creatinine clearance >= mL/min\r\n* For females, use % of calculated creatinine clearance (CrCl) value Renal insufficiency (defined as calculated creatinine clearance < mL/min) Calculated or measured creatinine clearance >= mL/min Creatinine clearance ( hour or calculated) > ml/min Renal disease, and we will use a calculated serum creatinine clearance over ml/min at the screening appointment as an exclusion criteria Creatinine clearance calculated >= mL/min Creatinine clearance < ml/min (calculated or measured) Creatinine clearance < mL/min (calculated or measured) Calculated creatinine clearance ? mL/min Calculated creatinine clearance >= mL/min Have a calculated creatinine clearance >= mL/min NORMAL VOLUNTEERS: Have a calculated creatinine clearance >= ml/min Calculated creatinine clearance >= mL/min calculated creatinine clearance > mL/min/. m Calculated creatinine clearance >= mL/min