Eastern Cooperative Oncology Group (ECOG) (World Health Organization [WHO]) performance status or or World Health Organization (WHO)/Eastern Cooperative Oncology Group (ECOG)-performance status - Eastern Cooperative Oncology Group (ECOG) (World Health Organization [WHO]/Gynecologic Oncology Group [GOG]/Zubrod score) performance status - World Health Organization (WHO)/Eastern Cooperative Oncology Group (ECOG) performance status of or at enrollment Performance status (World Health Organization [WHO]/Eastern Cooperative Oncology Group [ECOG] scale) - Eastern Cooperative Oncology Group (ECOG)/World Health Organization (WHO) performance status - World Health Organization (WHO)/Eastern Cooperative Oncology Group (ECOG) performance status of or at enrollment World Health Organisation (WHO) or Eastern Cooperative Oncology Group (ECOG) Performance status -. The Eastern Cooperative Oncology Group (ECOG)/World Health Organization (WHO) performance status of -.or patients with chronic lymphocytic leukemia requiring treatment age > years at the time of signing informed consent and ECOG/WHO performance status of - and a CIRS or Charlson co-morbidity score of or higher. Eastern Cooperative Oncology Group (World Health Organization) performance status of or Eastern Cooperative Oncology Group (ECOG)/World Health Organization (WHO) performance status - Subject has a Karnofsky score <, or a World Health Organization (WHO)/ Eastern Cooperative Oncology Group (ECOG) performance status ?. Subjects who have a performance status of may be considered for the study if the removal of their fluid would likely improve their performance score by or more. Eastern Cooperative Oncology Group (ECOG)/World Health Organization (WHO) performance status of - Patient has Karnofsky score >= or World Health Organization (WHO)/Eastern Cooperative Oncology Group (ECOG) =< if >= years of age Have a World Health Organization (WHO)/Eastern Cooperative Oncology Group (ECOG) performance score =< and life expectancy > months Karnofsky performance status of ? (or Eastern Cooperative Oncology Group (ECOG)/World Health Organization [WHO] equivalent) Karnofsky performance status of >= (or Eastern Cooperative Oncology Group [ECOG]/World Health Organization [WHO] equivalent) Karnofsky performance status (KPS) ? (Eastern Cooperative Oncology Group [ECOG]/World Health Organization [WHO] , , or ) Karnofsky performance status (KPS) ? (Eastern Cooperative Oncology Group [ECOG]/World Health Organization [WHO] , , or ) Karnofsky performance status of >= (or Eastern Cooperative Oncology Group [ECOG]/World Health Organization [WHO] equivalent) Karnofsky performance status of >= (or Eastern Cooperative Oncology Group [ECOG]/World Health Organization [WHO] equivalent) Karnofsky performance status of >= (or Eastern Cooperative Oncology Group [ECOG]/World Health Organization [WHO] equivalent) Karnofsky performance status of or greater (or Eastern Cooperative Oncology Group [ECOG]/World Health Organization [WHO] equivalent) Karnofsky performance status of >= (or Eastern Cooperative Oncology Group [ECOG]/ World Health Organization [WHO] equivalent) Karnofsky performance status of >= (or Eastern Cooperative Oncology Group [ECOG]/World Health Organization [WHO] equivalent) Karnofsky performance status of >= (Eastern Cooperative Oncology Group [ECOG]/World Health Organization [WHO] equivalent) Karnofsky performance status of >= (or Eastern Cooperative Oncology Group [ECOG]/World Health Organization [WHO] equivalent) Karnofsky performance status or Lansky play scale status of >= (or Eastern Cooperative Oncology Group [ECOG]/World Health Organization [WHO] equivalent) Karnofsky performance status of >= (or Eastern Cooperative Oncology Group [ECOG]/World Health Organization [WHO] equivalent) Karnofsky performance status or Lansky Play Scale status of >= (or Eastern Cooperative Oncology Group [ECOG]/World Health Organization [WHO] equivalent) Karnofsky performance status of >= (or Eastern Cooperative Oncology Group [ECOG]/World Health Organization [WHO] equivalent) Karnofsky performance status of > (or Eastern Cooperative Oncology Group [ECOG]/World Health Organization [WHO] equivalent) Karnofsky performance status of >= (or Eastern Cooperative Oncology Group [ECOG]/World Health Organization [WHO] equivalent) Karnofsky performance status of > (or Eastern Cooperative Oncology Group [ECOG]/World Health Organization [WHO] equivalent) Karnofsky performance status or Lansky Play Scale status of >= (or Eastern Cooperative Oncology Group [ECOG]/World Health Organization [WHO] equivalent)