Patient has had surgery within weeks prior to first dose Major surgery within weeks Major surgery or radiation therapy within weeks prior to the first study dose Recent major surgery within weeks prior to first infusion Patients who are less than weeks post-op after major surgery Has had major surgery in the past weeks. Major surgery within weeks prior to first dose Major surgery Major surgery in the last three weeks At least weeks must have elapsed since undergoing major surgery At least weeks from major surgery Major surgery: weeks All major surgery including prior surgery to the brain within weeks of commencement of study therapy Major surgery within weeks prior to the first study dose. Patients who underwent major surgery within weeks before the planned day for the first treatment At least weeks since major surgery or radiation therapy Major surgery within weeks of the first dose of study treatment Any major surgery, as determined by the Investigator, within weeks of IMP administration Major surgery: ? weeks Patients who have had major surgery within weeks prior to the first dose of study drug or have major surgery planned during the first weeks after MT- has finished. Radiation therapy or major surgery within weeks prior to first dose of study agent Major surgery within weeks prior to cycle , other than for diagnosis. No major surgery within weeks of first dose of sEPHB History of major surgery within weeks prior to first dose on this study Major surgery (as defined by the Investigator): ? weeks Major surgery within weeks before screening Major surgery within the past months < weeks since major surgery (i.e., laparotomy or thoracotomy) Major surgery within weeks of first dose of investigational product Major surgery within weeks before day . Major surgery within weeks prior to first dose Major surgery (major according to the Investigator's assessment) performed within weeks prior to first trial treatment or planned within months after screening, e.g.,hip replacement Received major surgery, radiotherapy, or immunotherapy within weeks of GSK administration Major surgery within the four weeks prior to initiating protocol therapy Major surgery without full recovery or major surgery within weeks of screening Major surgery within weeks prior to event At least weeks from major surgery Major surgery within weeks of enrolment Major surgery or treatment with any other investigational agent within weeks Major surgery within weeks of initiation of therapy; clearance letter from primary physician required Major surgery within weeks prior to first study dose Major surgery in the past weeks. A history of any major surgery within weeks prior to dosing Any major surgery within the last weeks Major surgery within four weeks before day Patients who have had major surgery within weeks of initiation of study medication Major surgery in the past weeks Major surgery or radiation therapy within weeks prior to the Baseline Visit. > weeks since major surgery >= weeks since major surgery Major surgery, or not recovered from major surgery within weeks before the first dose of study treatment Patients with major surgery or radiation therapy within weeks prior to first study dose. Major surgery within weeks prior to day Major surgery within weeks prior to study treatment. Major surgery in last weeks, minor surgery in the last weeks Major surgery/surgical therapy for any cause within weeks of Screening; Patient had major surgery within weeks prior to the first dose. Major surgery within weeks prior to first dose of STA- Major surgery or invasive intervention within weeks prior to first dose Any major surgery within the last four weeks. Any major surgery within the last four weeks. Major surgery within the last weeks; minor surgery within the last weeks Major surgery within weeks prior to inclusion Major surgery within four weeks before first IMP administration. Major surgery within weeks before day Major surgery without full recovery or major surgery within weeks of Screening. Minimum of four weeks since any major surgery, completion of radiation Patients less than weeks post major surgery Major surgery within four weeks before day Major surgery within weeks prior to the screening visit Subject has had major surgery within weeks prior to the first study dose. Major surgery within weeks prior to screening. Major surgery weeks from any major surgery Major surgery within weeks prior to first dose Major surgery within weeks of random assignment Major surgery within weeks prior to entering the study Major surgery within weeks prior to first dose Major surgery within the last weeks; minor surgery within the last weeks Surgery within weeks prior to first dose Major surgery within weeks prior to first dose Surgery within weeks prior to first dose. Major surgery or radiation therapy within four weeks of the first dose of ARQ Major surgery within weeks prior to entering the study Any major surgery or radiation therapy within four weeks. Major surgery within weeks Major surgery within weeks of Study Day >= weeks since major surgery Patient has had major surgery within the last weeks Major surgery within weeks of study randomisation. At least weeks must have elapsed from major surgery Major surgery within weeks prior to first dose Recent major surgery (within weeks), other than for diagnosis Major surgery within weeks (or within weeks following consultation with and approval of Medical Monitor) Major surgery within weeks of screening Major surgery or irradiation within two weeks Major surgery or irradiation within two weeks Major surgery within weeks or minor surgery within weeks prior the first dose of study medication Major surgery within weeks Major surgery within weeks or minor surgery within weeks prior to the first dose of study medication Major surgery within weeks prior to Day visit. Major surgery within weeks from cycle # Major surgery or radiation within weeks prior to st dose Major surgery within weeks Major trauma or surgery w/in prior weeks Major surgery within the last weeks At least weeks from major surgery with full recovery Major surgery within weeks prior to day Major surgery within weeks prior to first dose Subject has had major surgery within weeks prior to the first study dose. Major surgery within weeks before day Major surgery within weeks before day Major surgery (as judged by the investigator) within weeks Major surgery within weeks prior to first dose of ganetespib Subject has had major surgery within weeks prior to the first study dose. Major surgery within weeks, or minor surgery within weeks prior to day of cycle Any major surgery within weeks prior to day Major surgery or trauma within weeks Major surgery within weeks prior to IP administration Subjects may not have any major surgery within weeks At least weeks from prior major surgery or radiotherapy Patients who have had major surgery within weeks of initiation of study medication Major surgery within four weeks of the first dose of ARQ At least weeks from prior major surgery or radiotherapy. Radiotherapy or major surgery within weeks Major surgery within preceding weeks Major surgery within the past weeks. Major surgery performed within weeks prior to the first dose of study drugs or scheduled for major surgery during the study Major surgery within four weeks before consent date Major surgery within the past weeks Undergoing major surgery Patients who have had major surgery within weeks of initiation of study medication Major surgery or radiation treatment within months Any major surgery within the last four weeks. Major surgery within weeks Surgery within weeks prior to first dose Major surgery within weeks prior to first dose of study treatment. Subjects must not have had major surgery as determined by the PI within weeks before the first dose of investigational agent. Major surgery within weeks Major surgery in the past weeks (Arms and ) No major surgery within weeks of first dose of SGI-. Any chemotherapy within weeks, or major surgery or radiotherapy within the last days. History of major surgery within weeks prior to first dose on this study