Have an ECOG PS score of or ECOG PS -. ECOG PS of - ECOG PS >= Patients must have an ECOG PS of - at screening. ECOG PS , , or . The patient has an ECOG PS of -. PHASE IB: ECOG PS - Have an ECOG PS of to , with the exception of patients in Part (Cohort , unfit bladder cancer patients) who may have an ECOG PS of ECOG PS score of to + for (PS=), + for (PS=), + for (PS >). ECOG PS >. FULL STUDY INCLUSION CRITERIA: ECOG PS of or ECOG PS of to at screening. Has an ECOG PS of , , or ECOG PS -. Subjects with high PB blasts >% AND poor ECOG PS of . Patients must have an ECOG PS of - at screening and on the day prior to treatment. ECOG PS or ECOG PS -. ECOG PS - PS ECOG < Subjects must have ECOG PS of to . ECOG PS - Patient must have ECOG PS of to ECOG PS - PS to PS ECOG-PS or ECOG PS of ?. ECOG PS of or . Patients with an ECOG PS of may be entered upon review and approval of the medical monitor. ECOG PS of , , or Subjects must have ECOG PS of to . Eastern Cooperative Oncology Group performance status (ECOG PS) to . In case of ECOG PS , the PS has to be due to metastatic prostate cancer to the bone. ECOG PS - ECOG PS ? ; ECOG PS or . ECOG PS: - ECOG PS of - ECOG PS equals or less. ECOG PS ? PS or on the ECOG scale Subjects with an ECOG PS other than Subjects must have ECOG PS of to ECOG PS -. ECOG PS or ECOG PS to ECOG PS - ECOG PS - ECOG PS - ECOG PS -