AST and/or ALT > . x ULN with concomitant alkaline phosphatase > . x ULN
Have an alanine aminotransferase (ALT) ?.  ULN. (Note: There are no specific requirements for AST or alkaline phosphatase.)
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < . x upper limit of normal (ULN) with alkaline phosphatase =< . x ULN OR AST and ALT =< . x ULN, with alkaline phosphatase > . x ULN
ARM  - A: AST/ALT/alkaline phosphatase: =<  x ULN
ALT or aspartate AST > . x ULN concomitant with alkaline phosphatase > . x ULN
Bilirubin >.; alkaline phosphatase >x upper limit of normal (ULN); ALT/AST >x ULN. For patients with hepatic metastases, ALT/AST >x ULN is exclusionary.
AST and ALT =< . x ULN, with alkaline phosphatase > . x ULN
Liver function tests meeting one of the following criteria:\r\n* Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < . x upper limit of normal (ULN) with alkaline phosphatase < . x ULN OR\r\n* AST and ALT < . x ULN, with alkaline phosphatase > . x ULN
Bilirubin >.; alkaline phosphatase >x upper limit of normal (ULN); ALT/AST >x ULN.
Adequate hepatic function: bilirubin ?. x upper limit of normal (ULN), AST ?. x ULN, ALT ?. x ULN, alkaline phosphatase (liver fraction) ?. x ULN
Alkaline phosphatase (liver fraction) =< . X ULN; if AST or ALT is > . X ULN, then liver fraction of alkaline phosphatase should be =< . X ULN
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < . x upper limit of normal (ULN) with alkaline phosphatase =< . x ULN OR AST and ALT =< . x ULN, with alkaline phosphatase > . x ULN
To commence third line docetaxel, patients must have grade  or less neuropathy from prior oxaliplatin treatment; also bilirubin > upper limit of normal (ULN), or AST and/or ALT > . x ULN concomitant with alkaline phosphatase > . x ULN are not eligible for docetaxel therapy
AST (SGOT), ALT (SGPT) and Alkaline phosphatase > . times ULN
Alkaline phosphatase and AST may not both be > the ULN; for example, if the alkaline phosphatase is > the ULN but =< . x ULN, the AST must be =< the ULN; if the AST is > the ULN but =< . x ULN, the alkaline phosphatase must be =< ULN; Note: If alanine aminotransferase (ALT) is performed instead of AST (per institution's standard practice), the ALT value must be =< . x ULN; if both were performed, the AST must be =< . x ULN
* Patients with a history of Gilberts syndrome may be eligible provided total bilirubin is less than or equal to . x ULN and the AST, ALT, and alkaline phosphatase meet the criteria detailed
Adequate liver functions: AST and ALT =< xULN, alkaline phosphatase =< .x ULN, except if attributed to tumor, and bilirubin =< xULN.
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and alkaline phosphatase must be within the eligible; in determining eligibility, the more abnormal of the two values (AST or ALT) should be used; patients with alkaline phosphatase elevation secondary to the bony metastases rather than liver dysfunction may proceed with treatment on protocol after discussion with the principal investigator
Alkaline phosphatase =< upper limit of normal (ULN) and AST or ALT =< ULN eligible
Alkaline phosphatase >  x ULN but =< . x ULN and AST or ALT =< ULN eligible
Alkaline phosphatase > . x ULN but =<  x ULN and AST or ALT =< ULN eligible
Alkaline phosphatase >  x ULN and AST or ALT =< ULN ineligible
Alkaline phosphatase =< ULN and AST or ALT >  x ULN but =< . x ULN eligible
Alkaline phosphatase >  x ULN but =< . x ULN and AST or ALT >  x ULN but =< . x ULN eligible
Alkaline phosphatase > . x ULN but =<  x ULN and AST or ALT >  x ULN but =< . x ULN ineligible
Alkaline phosphatase >  x ULN and AST or ALT >  x ULN but =< . x ULN ineligible
Alkaline phosphatase =< ULN and AST or ALT > . x ULN but =<  x ULN eligible
Alkaline phosphatase >  x ULN but =< . x ULN and AST or ALT > . x ULN but =<  x ULN ineligible
Alkaline phosphatase > . x ULN but =<  x ULN and AST or ALT > . x ULN but =<  x ULN ineligible
Alkaline phosphatase >  x ULN and AST or ALT > . x ULN but =<  x ULN ineligible
Alkaline phosphatase =< ULN and AST or ALT >  x ULN ineligible
Alkaline phosphatase >  x ULN but =< . x ULN and AST or ALT >  x ULN ineligible
Alkaline phosphatase > . x ULN but =<  x ULN and AST or ALT >  x ULN ineligible
Alkaline phosphatase >  x ULN and AST or ALT >  x ULN ineligible
Subjects must have adequate liver function assessed by: total bilirubin <= . x upper limit of normal (ULN), aspartate aminotransferase (ALT) <= . x ULN (CTCAE Grade <=) or, if receiving BAY in combination with IV docetaxel, AST and ALT <=. x ULN if concomitant with alkaline phosphatase increase >. x ULN
Hepatic: Bilirubin ? . mg/dL (except in the case of Gilbert's syndrome or ongoing hemolytic anemia); and ALT, AST and Alkaline Phosphatase ?   ULN.
Alkaline phosphatase (AP) must be within the range allowing for eligibility, as follows:\r\n* =< ULN\r\n* =< . x ULN\r\n* =<  x ULN
Alkaline phosphatase and AST/ALT may not both be > the ULN; for example, if the alkaline phosphatase is > the ULN but =< . x ULN, then the AST/ALT must be =< the ULN; if the AST/ALT is > the ULN but =< . x ULN, then the alkaline phosphatase must be =< ULN
Patients with AST/ALT or alkaline phosphatase > ULN must have liver imaging that does not demonstrate metastatic disease
Hepatic function: total bilirubin ? . x ULN; ALT and AST ?  x ULN; alkaline phosphatase ? . x ULN
The subject has aspartate aminotransferase and/or alanine aminotransferase > .  ULN, with concomitant alkaline phosphatase > .  ULN.
Part  only: plasma total bilirubin <= ULN; ALT and/or AST <= . X ULN concomitant with alkaline phosphatase <= . X ULN.
Part  only: Patients with plasma total bilirubin > ULN; ALT and/or AST > . X ULN concomitant with alkaline phosphatase > . X ULN.
Elevated liver function tests (LFTs): Serum bilirubin >upper limit of normal (ULN), alanine (ALT) or aspartate (AST) aminotransferase > . ULN concomitant with alkaline phosphatase > . ULN
Patients enrolled without hepatic dysfunction must have laboratory test results for total bilirubin of less than the ULN, alkaline phosphatase (ALP) <=.x the ULN, and AST and ALT of <=the ULN.
Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) or serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) and alkaline phosphatase (AP) must be within the range allowing for eligibility:\r\n* AP =< upper limit of normal (ULN) AND AST or ALT >  x ULN, but =< . x ULN\r\n* AP >  x ULN, but =< . x ULN AND AST or ALT >  x ULN, but =< . x ULN\r\n* AP > . x ULN, but =<  x ULN AND AST or ALT =< ULN\r\n* AP >  x ULN not eligible
Hepatic lab values: Bilirubin>. ULN; AST/ALT >. ULN; Albumin <  g/dL; GGT > . ULN if Alkaline Phostphatase >. ULN