Patients must have a Lansky or Karnofsky performance status score of >= , corresponding to Eastern Cooperative Oncology Group (ECOG) categories , or ; use Karnofsky for patients > years of age and Lansky for patients =< years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age \r\n* Note: Neurologic deficits in patients with CNS tumors must have been relatively stable for at least days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age \r\n* Note: Neurologic deficits in patients with CNS tumors must have been relatively stable for at least days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; Note: Neurologic deficits in patients with CNS tumors must have been relatively stable for at least days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; note: neurologic deficits in patients with CNS tumors must have been relatively stable for at least days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; NOTE: neurologic deficits in patients with CNS tumors must have been relatively stable for at least days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Patients must have a Lansky or Karnofsky performance status score of >= , corresponding to Eastern Cooperative Oncology Group (ECOG) categories , or ; use Karnofsky for patients > years of age and Lansky for patients =< years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age\r\n* Note: Neurologic deficits in patients with CNS tumors must have been relatively stable for at least days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; Note: neurologic deficits in patients with CNS tumors must have been stable for at least days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; Note: Neurologic deficits in patients with CNS tumors must have been stable for at least days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age\r\n* Note: Neurologic deficits in patients with CNS tumors must have been relatively stable for at least days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; Note: neurologic deficits in patients with CNS tumors must have been relatively stable for at least days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; Note: neurologic deficits in patients with CNS tumors must have been stable for at least days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Patients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of , , or ; use Karnofsky for patients > years of age and Lansky for patients =< years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= % for patients =< years of age; Note: Neurologic deficits in patients with metastatic CNS tumors must have been relatively stable for a minimum of week prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for subjects > years of age and Lansky >= for subjects =< years of age; Note: subjects who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Lansky >= for patients =< years of age or as per institutional guidelines; Note: Patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky performance status >= % for patients > years of age and Lansky >= for patients =< years of age; Note: neurologic deficits in patients with CNS tumors must have been relatively stable for at least days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Patient must have a Karnofsky (if >= years of age) or Lansky performance score (if =< years of age) of >= by the time of registration; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= for patients >= years of age, and Lansky >= for patients < years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky performance scale (KPS for > years of age) or Lansky performance score (LPS for =< years of age) assessed within two weeks of enrollment must be >= ; patients who are unable to walk because of neurologic deficits, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score INCLUSION CRITERIA FOR STRATUM C: Karnofsky performance scale (KPS for > years of age) or Lansky performance score (LPS for =< years of age) assessed within two weeks of enrollment must be >= ; patients who are unable to walk because of neurologic deficits, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Patients >= years of age: Karnofsky >= %; patients =< years of age: Lansky scale >= %; subjects who are unable to walk because of paralysis, but who are upright in a wheelchair will be considered ambulatory for the purpose of calculating the performance score Karnofsky (> years of age) or Lansky (=< years of age) performance status (PS) %; Note: patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= for patients > years of age and Lansky >= for patients =< years of age. Patients who are unable to walk because of paralysis, but who are able to mobilize using a wheelchair, will be considered ambulatory for the purpose of assessing the performance score. Clinical performance status: Patients > years of age: Karnofsky ? %; patients < years of age: Lansky scale ? %; subjects who are unable to walk because of paralysis, but who are upright in a wheelchair will be considered ambulatory for the purpose of calculating the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; Note: neurologic deficits in patients with CNS tumors must have been relatively stable for at least days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; Note: Neurologic deficits in patients with CNS tumors must have been relatively stable for at least days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky > % for patients > years of age and Lansky > % for patients < years of age; neurologic deficits in patients with central nervous system (CNS) tumors must have been relatively stable for a minimum of days; patients who are unable to walk because of paralysis, but who are able to sit in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Patients must have a Karnofsky >= % for subjects > years of age and Lansky score >= for subjects =< years of age \r\n* Note: Subjects who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Participant's performance score must be ?% Karnofsky (for participants > years of age) or Lansky (for participants less than or equal to (?) years of age).Participants who are unable to walk because of paralysis and/or previous surgeries, but who are in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score. Karnofsky >= for patients > years of age and Lansky >= for patients =< years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age\r\n* Note: Neurologic deficits in patients must have been relatively stable for at least days prior to study enrollment; patients who are unable to walk because of paralysis, but who are in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Patients must have a performance status corresponding to Karnofsky or Lansky greater than or equal to %; use Karnofsky for patients > years of age and Lansky for patients =< years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Patients must have a performance status corresponding to Karnofsky or Lansky greater than or equal to %; use Karnofsky for patients > years of age and Lansky for patients =< years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; Note: neurologic deficits in patients with CNS tumors must have been stable for at least days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Performance status defined by Karnofsky or Lansky >= (except for patients with posterior fossa syndrome); use Karnofsky for patients >= years and Lansky for patients < years; note: patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered to be ambulatory for the purpose of assessing the performance score At the time of study enrollment patients must have a Karnofsky greater than or equal to % for patients > years of age and Lansky greater than or equal to for patients less than or equal to years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for subjects > years of age and Lansky >= for subjects =< years of age; note: subjects who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Performance level: Karnofsky > or equal to % for patients > years of age or Lansky > or equal to for patients < years of age; Note: patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Lansky score of or greater if =< years of age or a Karnofsky score of or greater if > years of age (NOTE: patients who are unable to walk because of paralysis, but who are in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score) Karnofsky performance scale (KPS for > years of age) or Lansky performance score (LPS for =< years of age) assessed within two weeks of enrollment must be >= ; patients who are unable to walk because of neurologic deficits, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Patients must have a performance status of >= by Lansky or Karnofsky, corresponding to Eastern Cooperative Oncology Group (ECOG) scores of , , or . Use Karnofsky for patients > years of age and Lansky for patients =< years of age. Patients who are unable to walk because of paralysis, but are up in a wheelchair will be considered ambulatory for the purposes of assessing the performance score Karnofsky ? for subjects > years of age and Lansky ? for subjects ? years of age \r\n* Note: subjects who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; Note: Neurologic deficits in patients with CNS tumors must have been stable for at least days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky performance scale (KPS for > years of age) or Lansky performance score (LPS for =< years of age) assessed within two weeks of enrollment must be >= ; patients who are unable to walk because of neurologic deficits, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= for patients >= years of age, and Lansky >= for patients < years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score; patients with pre-existing neurological deficits need to be stable prior to surgery or lumbar puncture (LP) as determined by the investigator Patients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of , , or ; use Karnofsky for patients > years of age and Lansky for patients =< years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Patients must have a performance status corresponding to an Eastern Cooperative Oncology Group (ECOG) scores of , or ; use Karnofsky for patients > years of age and Lansky for patients =< years of age; Note: patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Patients must have a Lansky or Karnofsky performance status score of >= , corresponding to Eastern Cooperative Oncology Group (ECOG) categories , or ; use Karnofsky for patients > years of age and Lansky for patients =< years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; Note: neurologic deficits in patients with CNS tumors must have been relatively stable for at least days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; Note: patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Clinical performance status: patients > years of age: Karnofsky >= %; patients =< years of age: Lansky scale >= %; subjects who are unable to walk because of paralysis, but who are upright in a wheelchair will be considered ambulatory for the purpose of calculating the performance score Performance level: Karnofsky >= for patients > years of age and Lansky >= for patients =< years of age); Note: patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Performance Status Karnofsky > % for patients > years of age or Lansky > for patients < years of age. Patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score. Patients must have Karnofsky performance score (for patients > years of age) or Lansky performance score (for patients =< years of age) >= % assessed within two weeks of study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky score >= for patients >= years of age and Lansky score >= for patients =< years of age; patients who are unable to walk because of paralysis but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= % for patients =< years of age; neurologic deficits in patients with central nervous system (CNS) tumors must have been relatively stable for a minimum of days; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky performance score ? for participants> year of age and Lansky play score ? for participants ? years of age. Neurologic deficits in participants with CNS tumors must have been relatively stable for at least days prior to study enrollment. Participants who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score RECURRENT/ PROGRESSIVE DIPG (STRATUM ): Karnofsky performance scale (KPS for > years of age) or Lansky performance score (LPS for =< years of age) assessed within days of enrollment must be >= %; patients who are unable to walk because of neurologic deficits, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score NON-PROGRESSED DIPG (STRATUM ): Karnofsky performance scale (KPS for > years of age) or Lansky performance score (LPS for =< years of age) assessed within days of enrollment must be >= %; patients who are unable to walk because of neurologic deficits, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; note: neurologic deficits in patients with central nervous system (CNS) tumors must have been relatively stable for a minimum of week prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Karnofsky >= % for patients > years of age or Lansky >= % for patients =< years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Performance Status: Karnofsky >= % for > years of age; Lansky >= % for children =< years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purposes of assessing performance score Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score ELIGIBILITY CRITERIA FOR ENROLLMENT ONTO APECSC: Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age); Note: neurologic deficits in patients with CNS tumors must have been stable for at least days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score GENERAL INCLUSION CRITERIA FOR SUBPROTOCOLS: Karnofsky >= % for patients > years of age and Lansky >= for patients =< years of age); Note: neurologic deficits in patients with CNS tumors must have been stable for at least days prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Patient must have a Lansky or Karnofsky performance of > % corresponding to Eastern Cooperative Oncology Group (ECOG) categories , , or ; Karnofsky will be used for patients > years of age and Lansky for patients < years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score