No history of cornea abnormalities Have major abnormalities documented by ECHO with Doppler: Significant cardiac abnormalities CNS abnormalities Current significant cardiac conduction abnormalities and hypokalemia as specified in the protocol. Gastrointestinal abnormalities including but not limited to: Has gastrointestinal abnormalities including: Certain cardiac abnormalities or history History or presence of bradydysrhythmia or conduction abnormalities Significant cardiac abnormalities; Significant gastrointestinal abnormalities, Any of the following cardiac abnormalities or history Subject has t(;), inv(), t(;) or t(;) karyotype abnormalities. History of specific cardiovascular abnormalities; Significant serum chemistry abnormalities No Severe or Chronic medical conditions including gastrointestinal abnormalities or significant cardiac history Clinically significant gastrointestinal abnormalities Cardiac abnormalities History or presence of clinically relevant cardiovascular abnormalities as per investigator assessment. Cardiac abnormalities Anyone with cardiac abnormalities or history Patients with uncorrectable electrolyte abnormalities. Patients must have a normal baseline ophthalmologic examination or have only clinically-insignificant abnormalities; patients with significant visual/ocular abnormalities identified during the baseline eye exam may be eligible after discussion with the study principal investigator (PI) and it is thought that the abnormalities pose no increased risk with study therapy De novo AML with karyotypic abnormalities characteristic of MDS: de novoAML must have cytogenetics with abnormalities per WHO. No significant hematologic abnormalities Clinically relevant cardiovascular abnormalities as judged by the investigator. Have major abnormalities documented by echocardiography with Doppler Presence of specific hematology and/or chemistry abnormalities Patients must have an electrocardiogram (EKG) that shows no significant abnormalities that are suggestive of active cardiac disease Cardiac abnormalities DONOR: No evidence of significant liver abnormalities Patient has any of the following cardiac abnormalities: Cardiac abnormalities: History or presence of clinically relevant cardiovascular abnormalities Cardiovascular abnormalities: The history or evidence of following cardiac abnormalities: Patients must have an electrocardiogram (EKG) with no significant abnormalities within days prior to registration Certain cardiac abnormalities. History or evidence of cardiac abnormalities. At least two manifestations drawn from at least two of the categories (clinical symptoms, laboratory abnormalities and radiographic abnormalities), which are at least possibly attributable to KICS and are not readily explicable from known medical conditions in the patient RADIOGRAPHIC ABNORMALITIES