Participants may not have any evidence of ongoing inadequately controlled hypertension (defined as a systolic blood pressure [BP] of >  mmHg or a diastolic BP of >  mmHg); patients with hypertension may not be on more than three antihypertensive medications for management of their blood pressure (medications that combine two anti-hypertensives into one are considered as two medications); it is strongly recommended that patients who require three antihypertensive medications for baseline management of pre-existing hypertension be actively followed by a cardiologist or blood pressure specialist for management of BP while on protocol
Adequately controlled blood pressure (BP) <  mmHg (systolic) and <  mmHg (diastolic) taken in the clinic setting by a medical professional within  weeks prior to starting study; patients with hypertension may be managed with up to a maximum of  antihypertensive medications; a cardiologist or blood pressure specialist must evaluate patients who are on  antihypertensive medications within  weeks of enrollment
Adequately controlled blood pressure (BP) with or without antihypertensive medications, defined as BP less than or equal to / mmHg at screening and no change in antihypertensive medications within  week prior to the Cycle  Day 
Poorly controlled hypertension (defined as systolic blood pressure [SBP] of >=  mmHg or diastolic blood pressure [DBP] of >= mmHg); Note: Initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; following antihypertensive medication initiation or adjustment, blood pressure (BP) must be re-assessed three times at approximately -minute intervals; at least  hours must have elapsed between anti-hypertensive medication initiation or adjustment and BP measurement; these three values should be averaged to obtain the mean diastolic blood pressure and the mean systolic blood pressure; the mean SBP / DBP ratio must be < / mmHg in order for a subject to be eligible for the study
History of uncontrolled hypertension (Blood pressure ? _/ mmHg and change in antihypertensive medication within  days prior to randomization) that is not well managed by medication and the risk of which may be precipitated by a VEGF inhibitor therapy.
Patients with uncontrolled hypertension as defined as systolic blood pressure of >  mmHg or diastolic blood pressure of >  mmHg documented on  consecutive measurements taken at least  hours apart are not eligible; Note: initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; following antihypertensive medication initiation or adjustment, blood pressure (BP) must be re-assessed three times at approximately -minute intervals; at least  hours must have elapsed between anti-hypertensive medication initiation or adjustment and BP measurement; these three values will be averaged to obtain the mean diastolic blood pressure and the mean systolic blood pressure; the mean systolic blood pressure (SBP)/diastolic blood pressure (DBP) ratio must be < / mmHg in order for a subject to be eligible for the study
Participants with a history of hypertension must be adequately controlled with antihypertensive medication and blood pressure (BP) must be less than / mmHg prior to initiation of ziv-aflibercept
Adequately controlled blood pressure (BP) with or without antihypertensive medications, defined as BP ?/ millimeters of mercury (mmHg) at Screening and no change in antihypertensive medications within  week before Cycle /Day 
Subject has uncontrolled hypertension, defined as a blood pressure reading >/ mmHg, despite maximum antihypertensive therapy.
Adequately controlled blood pressure with or without antihypertensive medications defined as blood pressure (BP) < / mmHg at screening and no change in antihypertensive mediation within  week prior to the screening visit
Adequately controlled blood pressure (BP) <  mmHg (systolic) and <  mmHg (diastolic) taken in the clinic setting by a medical professional within  weeks prior to starting study; patients with hypertension may be managed with up to a maximum of  antihypertensive medications; patients who are on  antihypertensive medications are highly recommended to be followed by a cardiologist or blood pressure specialist for management of BP while on protocol
Adequately controlled blood pressure (BP) <  mmHg (systolic) and <  mmHg (diastolic) taken in the clinic setting by a medical professional within  weeks prior to starting study; patients with hypertension may be managed with up to a maximum of  antihypertensive medications; patients who are on  antihypertensive medications are highly recommended to be followed by a cardiologist or blood pressure specialist for management of BP while on protocol
Patients must have adequately controlled blood pressure (BP), with a BP no greater than  mmHg (systolic) and  mmHg (diastolic) for eligibility; patients must have a BP of =< / mmHg taken in the clinic setting by a medical professional within  weeks prior to starting study; patients with hypertension may be managed with up to a maximum of three antihypertensive medications; it is strongly recommended that patients who are on three antihypertensive medications be followed by a cardiologist or blood pressure specialist for management of blood pressure while on protocol
Adequately controlled blood pressure (BP) with or without antihypertensive medications, defined as: BP less than th percentile for sex, age, and height/length at screening (as per National Heart Lung and Blood Institute guidelines) and no change in antihypertensive medications within -week prior to Cycle /Day . Osteosarcoma subjects  to  years should have BP ?/ mm Hg at screening and no change in antihypertensive therapy within  week prior to Cycle /Day .
Poorly controlled hypertension (defined as systolic blood pressure of >=  mmHg or diastolic blood pressure of >=  mmHg); Note: initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; following antihypertensive medication initiation or adjustment, blood pressure must be reassessed three times at approximately -minute intervals; at least  hours must have elapsed between antihypertensive medication initiation or adjustment and blood pressure measurement; these three values should be averaged to obtain the mean diastolic and systolic blood pressures, which must be < / mmHg in order for a patient to be eligible for the study
Poorly controlled hypertension (defined as systolic blood pressure [SBP] of >=  mmHg or diastolic blood pressure [DBP] of >= mmHg); note: initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; following antihypertensive medication initiation or adjustment, blood pressure (BP) must be re-assessed three times at approximately -minute intervals; at least  hours must have elapsed between anti-hypertensive medication initiation or adjustment and BP measurement; these three values should be averaged to obtain the mean diastolic blood pressure and the mean systolic blood pressure; the mean SBP/DBP ratio must be < / mmHg
Adequately controlled blood pressure; (defined as systolic blood pressure [SBP] of <  mmHg and diastolic blood pressure [DBP] of <  mmHg) on maximum of three antihypertensive medications; participants must have a blood pressure (BP) of < / taken in the clinic or hospital setting by a medical professional within  weeks prior to starting on study; it is strongly recommended that participants who are on  antihypertensive medications be followed by a cardiologist or a primary care physician for management of BP while on study
Adequately controlled blood pressure (systolic blood pressure [SBP] =< ; diastolic blood pressure [DBP] =<  mmHg) on maximum of three antihypertensive medications; patients must have a BP of =< / mmHg taken in the clinic setting by a medical professional within  weeks prior to starting study; it is strongly recommended that patients who are on three antihypertensive medications must be actively followed by a cardiologist or a primary care physician for management of BP while on protocol; patients must be willing and able to check and record daily blood pressure readings; blood pressure cuffs will be provided to patients randomized to cediranib alone and the combination of olaparib and cediranib arms
Poorly controlled hypertension (defined as systolic blood pressure [SBP] of >=  mmHg and/or diastolic blood pressure [DBP] of >=  mmHg); Note: initiation or adjustment of antihypertensive medication(s) is permitted prior to study registration
Poorly controlled hypertension, defined as systolic blood pressure (SBP) of >=  mmHg or diastolic blood pressure (DBP) of >= mmHg; Note: screening/baseline blood pressure (BP) must be assessed with three measurements at approximately -minute intervals; the mean SBP/DBP values from the three readings must be < / mmHg in order for a subject to be eligible for the study; if the subjects initial screening SBP/DBP is >= / mmHg, initiation or adjustment of antihypertensive medication(s) is permitted in an attempt to control the subjects BP level to below / mmHg; optimal blood pressure control must be achieved before registration and monitored
Poorly controlled hypertension (defined as systolic blood pressure of >=  mmHg or diastolic blood pressure of >=  mmHg); Note: initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; following antihypertensive medication initiation or adjustment, blood pressure must be reassessed three times at approximately -minute intervals; at least  hours must have elapsed between antihypertensive medication initiation or adjustment and blood pressure measurement; these three values should be averaged to obtain the mean diastolic and systolic blood pressures, which must be < / mmHg in order for a patient to be eligible for the study
Blood pressure (BP) ? / millimeter of mercury (mmHg) at screening with or without antihypertensive medications and no change in antihypertensive medications within  week prior to Cycle /Day .
Adequately controlled blood pressure (BP) with or without antihypertensive medications, defined as BP less than or equal to / mmHg at screening and no change in antihypertensive medications within  week prior to the Cycle  Day .
Patients who have any severe and/or uncontrolled medical conditions or other conditions that could affect their participation in the study as so judged by the treating physician; examples include but are not limited to:\r\n* Severely impaired lung function (e.g. use of home O, history of idiopathic lung disease [ILD], any evidence of ILD on scan)\r\n* Active (acute or chronic) severe infections requiring treatment with I.V. antibiotics\r\n* Liver disease such as cirrhosis, chronic active hepatitis or chronic persistent hepatitis\r\n* Poorly controlled hypertension (defined as systolic blood pressure [SBP] of >=  mmHg or diastolic blood pressure [DBP] of >=  mmHg); NOTE: initiation or adjustment of anti-hypertensive medication(s) is permitted prior to study entry; following anti-hypertensive medication initiation or adjustment, blood pressure (BP) must be re-assessed three times at approximately -minute intervals; at least  hours must have elapsed between anti-hypertensive medication initiation or adjustment and BP measurement; these three values should be averaged to obtain the mean diastolic blood pressure and the mean systolic blood pressure; the mean SBP/DBP ratio must be < / mmHg in order for a subject to be eligible for the study
Adequately controlled blood pressure (BP) with up to  antihypertensive agents, defined as BP less than or equal to / mm Hg at Screening and no change in antihypertensive therapy within  week prior to the Cycle/Day
Patients with pre-existing hypertension should be on a stable antihypertensive regimen and have a blood pressure =< / mmHg at the time of enrollment
Participants may not have any evidence of ongoing inadequately controlled hypertension (defined as a systolic blood pressure [BP] of >  mmHg or a diastolic BP of >  mmHg); patients with hypertension may not be on more than three antihypertensive medications for management of their blood pressure (medications that combine two anti-hypertensives into one are considered as two medications); it is strongly recommended that patients who require three antihypertensive medications for baseline management of pre-existing hypertension be actively followed by a cardiologist or blood pressure specialist for management of BP while on protocol
Poorly controlled hypertension (defined as systolic blood pressure [SBP] of >=  mmHg or diastolic blood pressure [DBP] of >=  mmHg)\r\nNote: initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; following antihypertensive medication initiation or adjustment, blood pressure (BP) must be re-assessed three times at approximately -minute intervals; at least  hours must have elapsed between anti-hypertensive medication initiation or adjustment and BP measurement; these three values should be averaged to obtain the mean diastolic blood pressure and the mean systolic blood pressure; the mean SBP / DBP ratio must be < / mmHg (or / mm Hg, if approved by principal investigator [PI] and the quality assurance monitor [QAM]) in order for a patient to be eligible for the study
Blood pressure < / at screening with or without antihypertensive medications and no change in antihypertensive medications within  week prior to initiation of treatment
Adequate blood pressure (BP) control with or without antihypertensive medications
History of any one or more of the following cardiovascular conditions within the past  months: \r\n* Cardiac angioplasty or stenting \r\n* Myocardial infarction \r\n* Unstable angina \r\n* Coronary artery bypass graft surgery \r\n* Symptomatic peripheral vascular disease\r\n* Class III or IV congestive heart failure, as defined by the New York Heart Association (NYHA)\r\n* Poorly controlled hypertension (defined as systolic blood pressure [SBP] of >= mmHg or diastolic blood pressure [DBP] of >= mmHg); Note: initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; blood pressure (BP) must be re-assessed on two occasions that are separated by a minimum of  hour; on each of these occasions, the mean (of  readings) SBP/DBP values from each BP assessment must be =< / mmHg in order for a subject to be eligible for the study\r\n* History of cerebrovascular accident including transient ischemic attack (TIA), pulmonary embolism or untreated deep venous thrombosis (DVT) within the past  months; Note: subjects with recent DVT who have been treated with therapeutic anticoagulating agents for at least  weeks are eligible
Adequately controlled blood pressure (BP) with or without antihypertensive medications, defined as BP less than / mmHg at screening and no change in antihypertensive medications within  week before Cycle /Day  (CD).
Patient must not have poorly controlled hypertension (defined as systolic blood pressure of >=  mmHg or diastolic blood pressure of >=  mmHg); initiation or adjustment of antihypertensive medications is permitted prior to study entry; blood pressure must be re-assessed on two occasions that are separated by a minimum of one hour; on each of these occasions, the mean (of  readings) from each assessment must be < / mmHg for a patient to be eligible for this study
Poorly controlled hypertension (defined as systolic blood pressure [SBP] of >=  mmHg or diastolic blood pressure [DBP] of >=  mmHg); Note: initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; blood pressure (BP) must be re-assessed on two occasions that are separated by a minimum of  hour; on each of these occasions, the mean (of  readings) SBP/DBP values from each BP assessment must be < / mmHg in order for a subject to be eligible for the study
Poorly controlled hypertension (defined as systolic blood pressure [SBP] of >=  mmHg or diastolic blood pressure [DBP] of >=  mmHg); Note: Initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; blood pressure (BP) must be re-assessed on two occasions that are separated by a minimum of  hour; on each of these occasions, the mean (of  readings) SBP/DBP values from each BP assessment must be < / mmHg in order for a subject to be eligible for the study
Poorly controlled hypertension (defined as systolic blood pressure [SBP] of >=  mmHg or diastolic blood pressure [DBP] of >= mmHg); Note: initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; blood pressure must be re-assessed prior to start of study therapy; the mean SBP/DBP values must be < / mmHg (OR / mmHg, if this criterion is approved by Safety Review Team) in order for a subject to be eligible for the study
Poorly controlled hypertension (defined as systolic blood pressure [SBP] of >=  mmHg or diastolic blood pressure [DBP] of >=  mmHg); Note: initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; blood pressure (BP) must be re-assessed on two occasions that are separated by a minimum of  hour; on each of these occasions, the mean (of  readings) SBP/DBP values from each BP assessment must be < / mmHg in order for a subject to be eligible for the study
Hypertension (defined as systolic blood pressure [SBP] of >=  mmHg OR diastolic blood pressure [DBP] of >=  mmHg) in spite of optimal medical management; note: initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; in this event, blood pressure (BP) must be re-assessed on two occasions that are separated by a minimum of  hour; on each of these occasions, the mean (of  readings) SBP/DBP values from each BP assessment must be < / mmHg in order for a subject to be eligible for the study
Poorly controlled hypertension (defined as systolic blood pressure [SBP] of >=  mmHg or diastolic blood pressure [DBP] of >= mmHg); initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; blood pressure must be re-assessed on two occasions that are separated by a minimum of  hours; the mean SBP/DBP values from each blood pressure assessment must be < / mmHg in order for a subject to be eligible for the study
EXPANSION COHORT ONLY: Poorly controlled hypertension (defined as systolic blood pressure [SBP] of >=  mmHg or diastolic blood pressure [DBP] of >= mmHg); initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; blood pressure must be re-assessed on two occasions that are separated by a minimum of  hours; the mean SBP/DBP values from each blood pressure assessment must be < / mmHg in order for a subject to be eligible for the study
Adequately controlled blood pressure (BP) with or without antihypertensive medications, defined as BP ?/ mmHg at Screening and no change in antihypertensive medications within  week prior to Cycle /Day  (C/D)
Patients may not have any evidence of pre-existing inadequately controlled hypertension (defined as a systolic blood pressure [BP] of >  mmHg or a diastolic BP of >  mmHg), and must have a normal blood pressure (=< / mmHg) taken in the clinic setting by a medical professional within  weeks prior to starting study; patients with hypertension may be managed with up to a maximum of three antihypertensive medications; patients who are on three antihypertensive medications must be actively followed by a cardiologist or blood pressure specialist for management of blood pressure while on protocol
Hypertension, defined for adults by SBP ?  mmHg and/or DBP ?  mmHg at baseline (or screening if baseline visit is skipped), and for pediatric patients by blood pressure greater than the th percentile for age, sex, and height (see Table -). Additionally, patients who were started on antihypertensive medication after HSCT or who have received additional antihypertensive medication after HSCT will be eligible, even if they don't have elevated blood pressure.
Poorly controlled hypertension (defined as systolic blood pressure [SBP] of >=  mmHg or diastolic blood pressure [DBP] of >=  mmHg); Note: initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; blood pressure must be re-assessed on two occasions that are separated by a minimum of  hours; the mean SBP/DBP values from each blood pressure assessment must be =<  systolic and  diastolic mmHg in order for a subject to be eligible for the study
Poorly controlled hypertension (systolic blood pressure [SBP] >=  mmHg or diastolic blood pressure [DBP] >=  mmHg); the initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry
Blood pressure (BP) ?/ millimeters of mercury (mmHg) at Screening with or without antihypertensive medications and no change in antihypertensive medications within  week prior to Cycle /Day .
Patients with a history of hypertension should be well controlled (blood pressure [BP] =< /) on a regimen of antihypertensive therapy
Patient must not have poorly controlled hypertension (defined as systolic blood pressure [SBP] of >=  mmHg or diastolic blood pressure [DBP] of >= mmHg)\r\n* Note: Initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; BP must be re-assessed on two occasions that are separated by a minimum of  hour; on each of these occasions, the mean (of  readings) SBP / DBP values from each BP assessment must be < / mmHg in order for a subject to be eligible for the study prior to study enrollment)
Adequately controlled blood pressure with or without antihypertensive medications defined as blood pressure (BP) < / mmHg at screening
Adequately controlled blood pressure (BP) with or without antihypertensive medications, defined as BP ?/ mmHg at Screening and no change in antihypertensive medications within  week prior to Cycle /Day .