Ability to comply with study procedures in the Investigator's opinion History of any psychiatric condition that might impair patient's ability to understand or comply with the requirements of the study or to provide consent History of any psychiatric condition that might impair patient's ability to understand or comply with the requirements of the study or to provide consent Any condition that would interfere with the subject's ability to comply with study instructions or might confound the study interpretation Any condition (e.g., known or suspected poor compliance, psychological instability, geographical location, etc) that, in the judgment of the investigator, may affect the patients ability to sign the informed consent and comply with study procedures Any other condition (e.g. psychiatric disorder) that, in the opinion of the Investigator, may interfere with the patient's ability to comply with the study requirements or visit schedule Any other condition which, in the opinion of the investigator, may compromise the subject's ability to follow study procedures and safely complete the study Presence of underlying medical condition that in the opinion of the investigator or sponsor could adversely affect the ability of the subject to comply with or tolerate study procedures and/or study therapy, or confound the ability to interpret the tolerability of combined administration of DS-A and nivolumab in treated subjects Any condition that, in the opinion of the investigator, would impair the subject's ability to comply with study procedures. In the investigators opinion, the patient has the ability to communicate satisfactorily with the investigator, to participate fully in the study, and comply with all its requirements Any other condition that, in the opinion of the Investigator, would impair the patients ability to comply with study procedures Any condition or behavior that in the judgment of the investigator, would compromise the patients ability to participate in the study and/or comply with study procedures Subjects with a condition which may interfere with the subjects' ability to understand the requirements of the study Any condition that in the opinion of the investigator would impair the patients' ability to comply with the study procedures. Presence of underlying medical condition that in the opinion of the investigator or sponsor could adversely affect the ability of the subject to comply with or tolerate study procedures and/or study therapy, or confound the ability to interpret the tolerability of combined administration of panobinostat and ipilimumab in treated subjects Any other condition that, in the opinion of the investigator, would impair the patient's ability to comply with study procedures Any physical or mental condition or social situation that in the opinion of the Investigator may interfere with the patient's ability to comply with the trial procedures E . Any severe acute or chronic medical condition which could impair the ability of the participant to participate to the study or interfere with interpretation of study results, or participants unable to comply with the study procedures. Ability to comply with study procedures, in the Investigator's opinion Any clinically significant condition or situation, other than the condition being studied that, in the opinion of the investigator, would impair with their ability to receive or tolerate the planned treatment, or interfere with the study evaluations or optimal participation in the study. A subject who, in the opinion of the sponsor-investigator will be uncooperative or unable to comply with study procedures Any condition (e.g., known or suspected poor compliance, psychological instability, geographical location, etc) that, in the judgment of the investigator, may affect the patient's ability to sign the informed consent and undergo study procedures. Subjects may not have an underlying medical condition that in the opinion of the investigator could adversely affect the ability of the subject to comply with or tolerate study procedures and/or study therapy, or confound the ability to interpret the tolerability of combined administration of dasatinib and ipilimumab in treated subjects Subjects with a condition which may interfere with the subjects' ability to understand the requirements of the study. Any condition that, in the opinion of the enrolling investigator, would interfere with the subjects ability to comply with the study requirements Clinically evident cognitive and/or behavioral impairment that in the opinion of the study investigator would impair the ability of the patient to adhere to the study procedures, specifically completing home activity monitoring Post-operative complications that in the opinion of the study investigator would impair the ability of the patient to adhere to the study procedures, specifically completing home activity monitoring Known history of a neurological and/or psychological disorder that in the physicians opinion may interfere with the patients ability to cooperate with study procedures Any condition that, in the opinion of the investigator, would impair the subject's ability to comply with study procedures; History of a neurological or psychological disorder that may interfere with the patients ability to cooperate with study procedures Subjects with current alcohol use, illicit drug use, or any other condition (e.g., psychiatric disorder) that, in the opinion of the Investigator, may interfere with the subject's ability to comply with the study requirements or visit schedule A subject who, in the opinion of the sponsor-investigator will be uncooperative or unable to comply with study procedures Has any condition that interferes with the ability of the subject to understand or comply with the requirements of the study. Any condition that, in the opinion of the principal investigator, would impair the patients ability to comply with study procedures Any condition that, in the opinion of the principal investigator, would impair the patients ability to comply with study procedures