Therapeutic anticoagulation with vitamin-K antagonists (e.g., warfarin) or with heparins and heparinoids; however, prophylactic anticoagulation as described below is allowed:\r\n* Low dose warfarin ( mg orally, once daily) with prothrombin time (PT)-INR =< . x ULN is permitted; infrequent bleeding or elevations in PT-INR have been reported in some subjects taking warfarin while on regorafenib therapy; therefore, subjects taking concomitant warfarin should be monitored regularly for changes in PT, PT-INR or clinical bleeding episodes\r\n* Low dose aspirin (=<  mg daily)\r\n* Prophylactic doses of heparin
Therapeutic anticoagulation with vitamin-K antagonists (e.g., warfarin) or with heparins and heparinoids\r\n* However, prophylactic anticoagulation as described below is allowed:\r\n** Low dose warfarin ( mg orally, once daily) with PT-INR =< . x ULN is permitted; subjects taking concomitant warfarin should be monitored regularly for changes in PT, PT-INR or clinical bleeding episodes\r\n** Low dose aspirin (=<  mg daily)\r\n** Prophylactic doses of heparin
Therapeutic anticoagulation with vitamin-K antagonists (e.g., warfarin) or with heparins and heparinoids\r\n* However, prophylactic anticoagulation as described below is allowed:\r\n** Low dose warfarin ( mg orally, once daily) with PT-INR =< . x ULN is permitted; infrequent bleeding or elevations in PT-INR have been reported in some subjects taking warfarin while on regorafenib therapy; therefore, subjects taking concomitant warfarin should be monitored regularly for changes in PT, PT-INR or clinical bleeding episodes\r\n** Low dose aspirin (=<  mg daily)\r\n** Prophylactic doses of heparin
Low dose warfarin ( mg orally, once daily) with PT-INR ? . x ULN is permitted. Infrequent bleeding or elevations in PT-INR have been reported in some subjects taking warfarin while on regorafenib therapy. Therefore, subjects taking concomitant warfarin should be monitored regularly for changes in PT, PT-INR, or clinical bleeding episodes.
Therapeutic anticoagulation with vitamin-K antagonists (e.g., warfarin) or with heparins and heparinoids\r\n* However, prophylactic anticoagulation as described below is allowed:\r\n** Low dose warfarin ( mg orally, once daily) with prothrombin time (PT)-international normalized ratio (INR) =< . x upper limit of normal (ULN) is permitted; subjects taking concomitant warfarin should be monitored regularly for changes in PT, PT-INR or clinical bleeding episodes\r\n** Prophylactic doses of heparin
Therapeutic anticoagulation with vitamin-K antagonists (e.g., warfarin) or with heparins and heparinoids; NOTE: Prophylactic anticoagulation as described below is allowed:\r\n* Low dose warfarin ( mg orally, once daily) with prothrombin time PT-INR =< . x ULN is permitted; subjects taking concomitant warfarin should be monitored regularly for changes in PT, PT-INR or clinical bleeding episodes\r\n* Low dose aspirin (=<  mg daily)\r\n* Prophylactic doses of heparin
Therapeutic anticoagulation with vitamin-K antagonists (e.g., warfarin) or with heparins and heparinoids; however, prophylactic anticoagulation as described below is allowed:\r\n* Low dose warfarin ( mg orally, once daily) with prothrombin time (PT)-international normalized ratio (INR) =< . x ULN is permitted; infrequent bleeding or elevations in PT-INR have been reported in some subjects taking warfarin while on sorafenib or capecitabine therapy; therefore, subjects taking concomitant warfarin should be monitored regularly for changes in PT, PT-INR or clinical bleeding episodes\r\n* Low dose aspirin (=<  mg daily)
Therapeutic anticoagulation with vitamin-K antagonists (e.g., warfarin) or with heparins and heparinoids; however, prophylactic anticoagulation as described below is allowed:\r\n* Low dose warfarin ( mg orally, once daily) with PT-INR =< . is permitted; infrequent bleeding or elevations in PT-INR have been reported in some subjects taking warfarin while on regorafenib therapy; therefore, subjects taking concomitant warfarin should be monitored regularly for changes in PT, PT-INR or clinical bleeding episodes\r\n* Low dose aspirin (=<  mg daily)\r\n* Prophylactic doses of heparin
Therapeutic anticoagulation with vitamin-K antagonists (e.g., warfarin) or with heparins and heparinoids; however, prophylactic anticoagulation as described below is allowed: . low dose warfarin ( mg orally, once daily) with prothrombin time [PT]-INR =< . x ULN is permitted; subjects taking concomitant warfarin should be monitored regularly for changes in PT, PT-INR or clinical bleeding episodes; we will monitor the PT/INR weekly for patients on warfarin and liver function test every  weeks (total bilirubin, and AST (serum glutamic oxaloacetic transaminase [SGOT]) and ALT (serum glutamic pyruvic transaminase [SGPT]) if hepatic metastases are present or if patients are on potentially hepatoxic agents such as acetaminophen or statins; . low dose aspirin (=<  mg daily); and . prophylactic doses of heparin