Patients who have undergone major surgery or trauma within days prior to the first dose of investigational product and/or present with any non-healing wound, fracture, or ulcer are NOT eligible for participation; procedures such as catheter placement not considered to be major surgery Major surgery or trauma within days prior to first dose of investigational product and/or presence of any non-healing wound, fracture, or ulcer (procedures such as catheter placement not considered to be major surgery) Patient has had major surgery or insufficient recovery from surgical-related trauma or wound healing within days of study day Insufficient recovery from surgical-related trauma or wound healing Patients who have had major surgery or have insufficient recovery from surgical-related trauma or wound healing within days from study day Patients who are less than weeks from surgery (except biopsies) or have insufficient recovery from surgical-related trauma or wound healing Insufficient recovery from surgical-related trauma or wound healing Subjects who are less than days from surgery or have insufficient recovery from surgical-related trauma or wound healing. Patients who are less than weeks from surgery or have insufficient recovery from surgical-related trauma or wound healing Major surgery or trauma within days prior to first dose of investigational product and/or presence of any non-healing wound, fracture, or ulcer (procedures such as catheter placement are not considered to be major surgery) Patient has had major surgery or insufficient recovery from surgical-related trauma or wound healing within days of study day Patients who are less than weeks from CRS/HIPEC or have insufficient recovery from surgical-related trauma or wound healing as determined by the patients surgeon Major surgery or trauma within days prior to first dose of pazopanib and/or presence of any non-healing wound, fracture, or ulcer (procedures such as catheter placement not considered to be major surgery) Prior major surgery or trauma within days prior to first dose of study drug and/or presence of any non-healing wound, fracture, or ulcer (procedures such as catheter placement not considered to be major) Major surgery or trauma within days prior to first dose of pazopanib and/or presence of any non-healing wound, fracture, or ulcer (procedures such as catheter placement not considered to be major surgery) Insufficient recovery from surgical-related trauma or wound healing Major surgery or trauma within days prior to first dose of study treatment and/or presence of any non-healing wound, fracture, or ulcer (procedures such as catheter placement not considered to be major surgery) Prior major surgery or trauma within days and/or presence of any non-healing wound, fracture or ulcer (procedures such as catheter placement not considered to be major) Major surgery or trauma within days prior to first dose of investigational product and/or presence of any non-healing wound, fracture, or ulcer (procedures such as catheter placement not considered to be major surgery) Patient must not have prior major surgery, trauma, presence of any non-healing wound, fracture, or ulcer within days prior to first dose of study drug Less than weeks from surgery or insufficient recovery from surgical-related trauma or wound healing Prior major surgery or trauma within days prior to registration and/or presence of any non-healing wound, fracture, or ulcer (procedures such as catheter placement not considered to be major); if the patient has a compression fracture secondary to tumor this should be treated and days elapsed prior to entry on the protocol Prior major surgery or trauma within days prior to first dose of study drug and/or presence of any non-healing wound, fracture, or ulcer (procedures such as catheter placement not considered to be major) Major surgery or trauma within days prior to first dose of study drug and/or presence of any non-healing wound, fracture, or ulcer not related to cancer (procedures such as catheter placement not considered to be major) Prior major surgery or trauma within days prior to first dose of study drug and/or presence of any non-healing wound, fracture, or ulcer (procedures such as catheter placement not considered to be major) Prior major surgery or trauma within days prior to first dose of pazopanib and/or presence of any non-healing wound, fracture, or ulcer (procedures such as catheter placement not considered to be major) Prior major surgery (defined as requiring general anesthesia) or trauma within days prior to first dose of study drug, and/or not recovered from effects of that surgery, and/or presence of any non-healing wound, fracture, or ulcer (procedures such as catheter placement not considered to be major), or patients that may require surgery during the course of the study EXPANSION COHORT ONLY: Prior major surgery (defined as requiring general anesthesia) or trauma within days prior to first dose of study drug, and/or not recovered from effects of that surgery, and/or presence of any non-healing wound, fracture, or ulcer (procedures such as catheter placement not considered to be major), or patients that may require surgery during the course of the study Prior major surgery or trauma within days prior to first dose of study drug and/or presence of any non-healing wound, fracture, or ulcer (procedures such as catheter placement not considered to be major) Prior major surgery or trauma within days prior to the protocol-mandated -week drug holiday and/or presence of any non-healing wound, fracture, or ulcer. Prior major surgery or trauma within days prior to the first dose of study drug and/or presence of any non-healing wound, fracture, or ulcer. Prior major surgery or trauma within days of the first dose of study drug and/or presence of any non-healing wound, fracture, or ulcer Major surgery or trauma within days prior to first dose of investigational product and/or presence of any non-healing wound, fracture, or ulcer Major surgery or trauma within days prior to first dose of study drug and/or presence of any non-healing wound, fracture or ulcer (catheter placement is not major surgery) Patient must not have prior major surgery or trauma within days prior to first dose of study drug and/or presence of any non-healing wound, fracture, or ulcer (procedures such as catheter placement not considered to be major)