Participants with inadequate mental capacity to complete quality of life questionnaires Significant mental illness in the -week period preceding drug administration. Altered mental status preventing consent or answering questions during conduct of the trial will be excluded for safety purposes. History of documented seizure disorder, presence of cerebellar dysfunction, dysphasia or altered mental status on neurological examination Psychiatric disorder or a mental deficiency of the patient that is sufficiently severe to make compliance with the treatment unlikely, and making informed consent impossible. Sufficient mental capacity to provide informed consent and answer Short-Form Six-Dimension health index (SF-D) and Borg score questions Any mental or physical condition or disease or past medical history that mitigates against following the protocol Mini-mental status exam (MMSE) >= Part of another study that may interfere with our outcome of interest, unstable mental condition Mental condition that prevents patient from performing the study activities and requirements Psychiatric disorder or a mental deficiency of the patient that is sufficiently severe to make compliance with the treatment unlikely, and making informed consent impossible Mental incompetence or criminal incarceration psychiatric conditions e.g. patients unlikely to comply with the protocol, e.g. mental condition rendering the patient unable to understand the nature, scope, and possible consequences of participating in the study Active neurologic disorder (i.e. weakness, altered mental status) peripheral neuropathy alone does not exclude a patient Mental condition rendering the subject unable to understand the nature, scope, and possible consequences of the study Mental condition rendering the subject unable to understand the nature, scope, and possible consequences of the study Inability to participate in study activities due to physical or mental limitations Inability to participate in study activities due to physical or mental limitations Overt psychosis, mental disability, otherwise incompetent to give informed consent, or history of non-compliance Patients with severe personality disorder or mental illness that would preclude compliance with the study Has a mental incapacity or language barriers precluding adequate understanding, co-operation, and compliance with the study requirements. Active suppurative cholangitis (hypotension, acidemia, mental status changes) Subjects with uncontrolled medical or mental illness that, in the Investigator's judgement, could affect treatment tolerability or compliance. Unmanaged/uncontrolled mental health disorder Patients must have fully intact mental status and normal neurologic abilities. Intact mental status is defined by the capacity to identify and recall one's identity and place in time and space. Assessment of mental status and documentation of fully intact mental status by pediatric criteria, will be completed using physical and mental exam by the referring doctor or oncologist Mini Mental Status Exam (MMSE) >= prior to study entry Any physical or mental condition that, in the opinion of the PI, would cause the risk/benefit ratio of participation to be unacceptable Mini Mental Status Exam (MMSE) >= prior to study entry Stable physical and mental health Patients must have fully intact mental status and normal neurologic abilities; intact mental status is defined by the capacity to identify and recall one's identity and place in time and space; assessment of mental status and documentation of fully intact mental status will be completed using physical and mental exam by the referring doctor or oncologist All patients must have a baseline Mini Mental Status Examination score >= Mental condition rendering the patient unable to understand the nature, scope, and possible consequences of the trial History of serious chronic mental disorder or drug-abuse accompanied by documented problems of compliance with therapeutic programs Sufficient mental capacity to comply with the protocol requirements, Patient shows evidence of encephalopathy as defined by a change in mental status since the onset of aGVHD. Mini Mental Status Exam (MMSE) >= prior to study entry Unable to participate in all necessary study activities due to physical or mental limitations Patients with known primary or metastatic CNS disease (cohort B), are not eligible if they have a mini mental state exam score < or evidence of leptomeningeal disease Meet Diagnostic and Statistical Manual of Mental Disorders (DSM)-V criteria for insomnia and score >= on the Insomnia Severity Index Individuals with diminished mental capacity Individuals with diminished mental capacity Those mentally or physically unable to read the consent form or other study materials and/or participate in the consent and engagement with the CaringGuidance program; women who have been hospitalized for mental health issues or substance abuse in the past year are ineligible Diagnosis of major mental illness on the medical record (verified by the recruiter) Patient scores >= on the Mini-Mental Adjustment to Cancer cognitive avoidance subscale Patients who are unable to communicate or cooperate with the investigator due to language problems, poor mental development, or impaired cerebral function are not eligible. Serious mental illness (e.g., schizophrenia), which may interfere with engagement in the intervention Dementia as assessed by a mini-mental status exam (MMSE) score < on initial screening PATIENTS: Delirium as per Diagnostic and Statistical Manual of Mental Disorders (DSM-V) criteria Medical conditions that would prohibit the safe implementation of a yoga practice (e.g., vertigo, compromised mental status) Cognitive impairment evident patients will be evaluated with Folstein Mini-Mental Status Examination and excluded with a score less than Any physical or mental health condition that would interfere with full participation in the study, including individuals who are unable to read consent materials or appear to lack the capacity to consent Patients with Mini-Mental State Examination (MMSE) < will be ineligible for participation in the therapeutic trial Individuals with the following characteristics will be excluded: male breast cancer survivors, non-ambulatory, unable to provide informed consent; have a major mental illness (i.e., schizophrenia); have a mental illness that is not being treated/controlled (i.e., bipolar disorder); and reside > miles from the research site Cognitive impairment as indicated by a baseline Folstein Mini-Mental Status Examination of < Mental impairment leading to inability to cooperate Mental impairment leading to inability to cooperate Presence of relatively intact cognition defined by normal Mini Mental State Questionnaire according to age and education level; a score of or above is usually considered normal A Mini-Mental State Exam Score (MMSE) of at least Children who meet the above criteria, but whose treating oncologist advises against study participation for physical health, mental health (parent or child) or logistical reasons No evidence of dementia (Mini Mental State Examination [MMSE] >= ) but some evidence of cognitive impairment (each subject will be required to answer in the affirmative: do you have problems with memory and attention since having chemotherapy, and do you believe chemotherapy contributed to the problems?) Substantial dementia (based on Folstein Mini Mental State Examination < out of ) Patient has physical and mental capabilities to take part in study Cognitive impairment as assessed by the -item Mini-Mental Status Exam Assessed as competent based on responses to mental status screener A score of or below on the Mini Mental Status Exam (MMSE) triggers a review by an investigational team before enrolling Co-morbid delirium, dementia, mental illness, or neurocognitive deficit prohibiting informed consent and/or ability to complete study procedures Mini-Mental State Examination score of or below Mental incapacity Willing and able to provide informed consent as demonstrated by passing screening tool questions that includes the Short Portable Mental Status Questionnaire, use of antipsychotic medications, and suicidal ideations Delirium as per the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) criteria Mental incapacitation or significant emotional or psychiatric disorder that, in the opinion of the investigator, precludes study entry Sufficient mental capacity to answer SF-D and Borg score questions Individuals with a physical or mental impairment which would preclude their ability\n to perform the intervention. Mental incapacitation or significant emotional or psychological disorder that, in the opinion of the investigators, precludes study entry Individuals unable to complete art therapy activities independently due to physical and/or mental impairment INCLUSION CRITERIA FOR PATIENTS: No alterations in mental status INCLUSION CRITERIA FOR FAMILY MEMBERS: No alterations in mental status Mini Mental State Exam score greater than or equal to Mini mental state exam score less than Patient unable to attend to scheduled medical monitoring due to geographical, social or mental reasons Individuals with neurological, mental or psychiatric disorders Mental incapacitation or significant emotional or psychological disorder that, in the opinion of the investigators, precludes study entry (these patients may not be able to cooperate with this slightly invasive procedure or with the data collection process) Mental impairment leading to inability to cooperate Serious mental illness or developmental disabilities; subjects should be free of serious mental illness or developmental disability that would limit participation, including eating disorders Have no significant co-morbidity that precludes participation (i.e. acute, life-threatening illness, communication barriers such as a tracheal tube placement, or altered mental status such as dementia) Participant has a known diagnosis of mental incapacitation that may affect their ability to consent and be compliant with the protocol Have heart disease, lung disease, or mental illness Any physical or mental limitation that would prevent participation in study activities (Including but not limited to grade neuropathy or inability to ambulate) Stable physical/mental health Stable physical/mental health In stable physical/mental health Diagnosis of substance dependence other than nicotine (screened using DSM IV TR criteria) Diagnostic and Statistical Manual of Mental Disorders, fourth edition stable physical/mental health, Age and mental status wherein he/she is unable to cooperate for MRI study Patients incapable of giving informed written consent, due to mental disability, altered mental status,\r\nconfusion, cognitive impairment, or psychiatric disorders\r\n* Patients scoring . or lower on the University of California, San Diego Brief Assessment of Capacity to Consent (UBACC) questionnaire will not be allowed on study Subjects incapable of giving informed written consent, for the following reasons:\r\n* Inability to adhere to the experimental protocols for any reason\r\n* Inability to communicate with the research team\r\n* Limited ability to give informed consent due to mental disability, altered mental status, confusion, or psychiatric disorders\r\n* Prisoners or other individuals deemed to be susceptible to coercion Subjects incapable of giving informed written consent, for the following reasons:\r\n* Inability to adhere to the experimental protocols for any reason\r\n* Inability to communicate with the research team\r\n* Mental disability, altered mental status, confusion, or psychiatric disorders\r\n* Prisoners or others susceptible to coercion Patients incapable of giving informed written consent, for the following reasons:\r\n* Inability to adhere to the experimental protocols for any reason\r\n* Inability to communicate with the research team\r\n* Limited ability to give informed consent due to mental disability, altered mental status, confusion, cognitive impairment, or psychiatric disorders\r\n** Patients scoring . or lower on the University of California at San Diego (UCSD) Brief Assessment of Consent Capacity (UBACC) Capacity to Consent Questionnaire will be excluded\r\n* Prisoners or other individuals deemed to be susceptible to coercion Subjects incapable of giving informed written consent, for the following reasons:\r\n* Inability to adhere to the experimental protocols for any reason\r\n* Inability to communicate with the research team\r\n* Limited ability to give informed consent due to mental disability, altered mental status, confusion, or psychiatric disorders\r\n* Prisoners or other individuals deemed to be susceptible to coercion Any condition that would alter the patients mental status, prohibiting the basic understanding and/or authorization of informed consent Mothers need to be free of serious mental illness (e.g., cognitive and psychotic disorders) or developmental disability that would limit participation or preclude informed consent Unable to provide consent due to a mental, emotional, or physical handicap, that keep them from understanding the consent information Obvious physical or mental disability that would prevent participant from interacting with a tablet device Short portable mental status questionnaire (SPMSQ) score of less than \intact mental functioning\ ( or more errors) Altered mental state