First relapse of B-ALL, allowable sites of disease include isolated bone marrow, combined bone marrow and CNS and/or testicular, and isolated CNS and/or testicular; extramedullary sites are limited to the CNS and testicles
ELIGIBILITY CRITERIA - PHASE I (ARMS A, B, C): No evidence of isolated extramedullary relapse (i.e., testicular or central nervous system [CNS])
ELIGIBILITY CRITERIA - PHASE II (ARM D): No evidence of isolated extramedullary relapse (i.e., testicular or CNS)
Recurrent or refractory ALL limited to isolated testicular
Extramedullary disease status: patients with isolated CNS disease or isolated testicular disease are not eligible
Recurrent or refractory ALL limited to isolated testicular or isolated central nervous system (CNS) disease
Isolated extramedullary relapse (i.e. testicular, central nervous system)
Patients with isolated central nervous system (CNS), testicular, or other extramedullary site of relapse
Recurrent or refractory ALL limited to isolated testicular disease
Isolated extramedullary relapse (i.e., testicular, CNS).
Isolated extramedullary relapse (leukemia) or isolated CNS lymphoma
Isolated extramedullary relapse (i.e., testicular or CNS)