Patient has had major surgery within days prior to treatment start or has not recovered from major side effects (tumor biopsy is not considered as major surgery) Major surgery =< days prior to registration or has not recovered from major side effects (tumor biopsy is not considered as major surgery) Participants who have had major surgery within weeks prior to starting study drug or has not recovered from major side effects (tumor biopsy is not considered as major surgery) Patient has had major surgery within days prior to starting study drug or has not recovered from major side effects (tumor biopsy is not considered as major surgery) Major surgery within days prior to starting study drug or has not recovered from major side effects (tumor biopsy is not considered as major surgery) Patient has had major surgery within days prior to starting study drug or has not recovered from major side effects (tumor biopsy is not considered as major surgery) Patient has had major surgery within days prior to starting study drug or has not recovered from major side effects (tumor biopsy is not considered as major surgery) Patient has had major surgery within days prior to starting study drug or has not recovered from major side effects (tumor biopsy is not considered as major surgery) Major surgery within days prior to starting study drug or has not recovered from major side effects of the surgery. Subject has had major surgery within days prior to registration or has not recovered from major side effects of the surgery (tumor biopsy is not considered as major surgery). Patient has had major surgery within days prior to starting study drug or has not recovered from major side effects (tumor biopsy is not considered as major surgery) Major surgery within days prior to starting study drug or has not recovered from surgical complications (tumor biopsy is not considered as major surgery) Had major surgery within days prior to starting study drug or has not recovered from major side effects (tumor biopsy is not considered major surgery) resulting from a prior surgery Has had any major surgery within days prior to starting study drug or has not recovered from major side effects (tumor biopsy is not considered major surgery) resulting from a prior surgery Patient has had major surgery within days prior to starting study drug or has not recovered from major side effects (all surgical wounds must be fully healed); for the purpose of this criterion, a major surgical procedure is defined as one requiring the administration of general anesthesia (tumor biopsy is not considered as major surgery) Major operation within days prior to starting study drug or not recovered from surgical complications; neither tumor biopsy nor central line insertion are considered a major operation Patient has had major surgery within days prior to starting study drug or has not recovered from major side effects Patient has had major surgery within days prior to starting study drug or has not recovered from major side effects (tumor biopsy is not considered as major surgery) Patient has had major surgery within days prior to starting study drug or has not recovered from major side effects (tumor biopsy is not considered as major surgery) Subject has had major surgery within days prior to starting study drug or has not recovered from major side effects Subject has had major surgery within days prior to starting study drug or has not recovered from major side effects Patient has had major surgery =< days prior to registration or has not recovered from major side effects (tumor biopsy is not considered as major surgery) Patient has had major surgery within days prior to starting study drug or has not recovered from major side effects (tumor biopsy is not considered a major surgery) Patient has had major surgery within days prior to starting study drug or has not recovered from major side effects (tumor biopsy is not considered as major surgery). Patient has had major surgery within days prior to starting study drug or has not recovered from major side effects (tumor biopsy is not considered as major surgery) Patient had major surgery within days prior to starting study drug or has not recovered from major side effects of the surgery Patient has had major surgery within days prior to starting study drug or has not recovered from major side effects. Major surgery within days prior to starting Investigational Product or has not recovered from major side effects. Patient has had major surgery within days prior to starting study drug or has not recovered from major side effects