Patients with known macular degeneration, uncontrolled glaucoma, or cataracts are not eligible Uncontrolled glaucoma with intraocular pressure ? mmHg Uncontrolled glaucoma (topical medications allowed) Uncontrolled glaucoma (topical medications allowed) Glaucoma Patients with macular degeneration with markedly decreased visual acuity, patients with markedly decreased visual acuity (no specific etiology) or uncontrolled glaucoma Uncontrolled narrow-angle glaucoma Part : history of glaucoma Patients with angle-closure glaucoma Uncontrolled glaucoma (topical medications allowed) Patients with macular degeneration, uncontrolled glaucoma or markedly decreased visual acuity Patients with macular degeneration, uncontrolled glaucoma, or markedly decreased visual acuity based on physicians assessment Patients with known macular degeneration or uncontrolled glaucoma Patients with macular degeneration, uncontrolled glaucoma, or markedly decreased visual acuity Clinically significant glaucoma, retinitis pigmentosa, or macular degeneration. History of newly diagnosed or uncontrolled glaucoma/intraocular pressure > mm Hg as measured by tonography Uncontrolled glaucoma with intra-ocular pressures >mm Hg History of glaucoma Patients with known severe macular degeneration, uncontrolled glaucoma, or markedly decreased visual acuity Subjects with narrow angle glaucoma Macular degeneration, uncontrolled glaucoma, or markedly decreased visual acuity. Glaucoma diagnosed within one month prior to study Day . History of or active glaucoma Conditions that may increase intraocular pressure (e.g. glaucoma, acute globe injury) PATIENTS: History of myasthenia gravis or acute narrow angle glaucoma Patients with glaucoma No history of untreated narrow angle glaucoma within weeks prior to registration History of myasthenia gravis or acute narrow angle glaucoma Have glaucoma Have glaucoma History of glaucoma