Patients, who have had a major surgery or significant traumatic injury within weeks of start of study drug, patients who have not recovered from the side effects of any major surgery (defined as requiring general anesthesia) or patients that may require major surgery during the course of the study Patients, who have had a major surgery or significant traumatic injury within weeks of start of study drug, patients who have not recovered from the side effects of any major surgery (defined as requiring general anesthesia) or patients that may require major surgery during the course of the study Patients who may require major surgery during the course of the study Patients, who have had a major surgery or significant traumatic injury within weeks of start of study drug, patients who have not recovered from the side effects of any major surgery (defined as requiring general anesthesia) or patients that may require major surgery during the course of the study Patients who have had major surgery or significant traumatic injury within weeks prior to registration, patients who have not recovered from the side effects of any major surgery (defined as requiring general anesthesia), or patients that may require major surgery during the course of the study Patients who have had a major surgery or significant traumatic injury within weeks of start of study drug, patients who have not recovered from the side effects of any major surgery (defined as requiring general anesthesia) or patients that may require major surgery during the course of the study Patients, who have had a major surgery or significant traumatic injury within weeks of start of study drug, patients who have not recovered from the side effects of any major surgery (defined as requiring general anesthesia) or patients that may require major surgery during the course of the study The participant has electively planned or will require major surgery during the course of the study. Have electively planned or will require major surgery during the course of the study. Patients, who have had a major surgery or significant traumatic injury (injury requiring > weeks [ days] to heal) within weeks ( days) of start of study drug, patients who have not recovered from the side effects of any major surgery (defined as requiring general anesthesia) or patients that are expected to require major surgery, other than cytoreductive nephrectomy +/- retroperitoneal lymph node dissection, during the course of the study. Patients, who have had a major surgery or significant traumatic injury (injury requiring > weeks [ days] to heal) within weeks ( days) of start of study drug, patients who have not recovered from the side effects of any major surgery (defined as requiring general anesthesia) or patients that are expected to require major surgery during the course of the study Patients, who have had a major surgery or significant traumatic injury within weeks of start of study drug, patients who have not recovered from the side effects of any major surgery (defined as requiring general anesthesia) or patients that may require major surgery during the course of the study Patients, who have had a major surgery or significant traumatic injury within weeks of start of study drug, patients who have not recovered from the side effects of any major surgery (defined as requiring general anesthesia) or patients that may require major surgery during the course of the study Patients who have had a major surgery or significant traumatic injury within weeks of start of study drug, patients who have not recovered from the side effects of any major surgery (defined as requiring general anesthesia) or patients that may require major surgery during the course of the study Patients who:\r\n* Have had a major surgery or significant traumatic injury within weeks from day of study drug\r\n* Have not recovered from the side effects of any major surgery (defined as requiring general anesthesia) or\r\n* Are anticipated to require major surgery during the course of the study Major surgery within weeks of the start of study treatment defined as those surgeries that require general anesthesia; insertion of a vascular access device is NOT considered major surgery Patients who have had a major surgery or significant traumatic injury within weeks of start of study drug, patients who have not recovered from the side effects of any major surgery (defined as requiring general anesthesia) or patients that may require major surgery during the course of the study Patients, who have had a major surgery or significant traumatic injury within weeks of start of study drug, patients who have not recovered from the side effects of any major surgery (defined as requiring general anesthesia) or patients that may require major surgery during the course of the study Patients that may require major surgery during the course of the study Patients, who have had a major surgery or significant traumatic injury within weeks of start of study drug, patients who have not recovered from the side effects of any major surgery (defined as requiring general anesthesia) or patients that may require major surgery during the course of the study Patients who have had a major surgery or significant traumatic injury within weeks of start of study drug, patients who have not recovered from the side effects of any major surgery (defined as requiring general anesthesia), or patients that may require major surgery during the course of the study History of major surgery or traumatic injury =< days prior to registration or other major anticipated procedures requiring general anesthesia during study participation Major surgery or significant traumatic injury (or unhealed surgical wounds) occurring within days prior to receiving study drug, or planned surgery requiring general anesthesia Major surgery or significant traumatic injury within weeks of randomization or patients that may require major surgery during the course of the study. Patients who have had a major surgery of significant traumatic injury within weeks of start of study drug, patients who have not recovered from the side effects of any major surgery (defined as requiring general anesthesia) or patients that may require major surgery during the course of the study Major surgery or significant traumatic injury (or unhealed surgical wounds) occurring within days prior to receiving study drug, or planned surgery requiring general anesthesia Patients, who have had a major surgery or significant traumatic injury within weeks of start of study drug, patients who have not recovered from the side effects of any major surgery (defined as requiring general anesthesia) or patients that may require major surgery during the course of the study Patients who have not recovered from the side effects of a major surgery or significant traumatic injury or patients that may require major surgery during the course of the study