INCLUSION CRITERIA FOR SECOND-LINE THERAPY: Patients may have a transfusion of red blood cells to meet the hemoglobin requirement INCLUSION CRITERIA FOR THIRD-LINE THERAPY: Patients may have a transfusion of red blood cells to meet the hemoglobin requirement Blood transfusion to meet the inclusion criteria will be allowed Platelet count > /mm^; blood transfusion to meet the inclusion criteria will not be allowed Hemoglobin (Hb) > g/dL; blood transfusion to meet the inclusion criteria will not be allowed Blood transfusion to meet the inclusion criteria will be allowed Blood transfusion to meet the inclusion criteria will not be allowed Note: supportive care (e.g. transfusion of red blood cells) is allowed to meet eligibility criteria Platelet count >= ,/mm^; blood transfusion to meet the inclusion criteria will not be allowed Hemoglobin (Hb) >= g/dL; blood transfusion to meet the inclusion criteria will not be allowed Platelet count >= ,/mm^; blood transfusion to meet the inclusion criteria will not be allowed Hemoglobin (Hb) >= g/dL; blood transfusion to meet the inclusion criteria will not be allowed Platelet count >= /mm^; blood transfusion to meet the inclusion criteria will not be allowed Hemoglobin (Hb) >= g/dL; blood transfusion to meet the inclusion criteria will not be allowed Blood transfusion to meet the inclusion criteria will be allowed Platelet count >= ,/mm^; blood transfusion to meet the inclusion criterion will not be allowed Hemoglobin (Hb) >= g/dL; blood transfusion to meet the inclusion criterion will not be allowed Blood transfusion to meet the following laboratory requirements will not be allowed Platelet count >= ,/mm^; blood transfusion to meet the inclusion criteria will not be allowed Hemoglobin (Hb) >= g/dL; blood transfusion to meet the inclusion criteria will not be allowed Blood transfusion to meet the inclusion criteria will not be allowed