Major surgery within weeks of first dose of study drug Major surgery within weeks before the first dose of study drug Major surgery, radiation, or treatment with any other investigational drug within weeks of study treatment Prior major treatment-related surgery completed at least weeks prior to study drug administration; Major surgery within weeks of the first dose of study drug Has had major surgery within weeks before first study drug administration Major surgery within weeks of first dose of study drug Major surgery within weeks of first dose of study drug Any major surgery within weeks prior to the first dose of study drug. CRITERIA SPECIFIC FOR COHORT # (MCL): Major surgery within weeks of first dose of study drug Major surgery within weeks of first dose of study drug Major surgery within weeks prior to first dose of study drug Major surgery within weeks of initiation of study drug Major surgery within weeks prior to registration or first dose of drug Major surgery within weeks prior to first dose of study drug Major surgery within weeks of first dose of study drug Major surgery within weeks of initiation of study drug Major surgery less than weeks prior to the first dose of study drug; minor surgery less than weeks prior to the first dose of study drug Major surgery within weeks of first dose of study drug Major surgery within weeks of first dose of study drug Major surgery within weeks of first dose of study drug Major surgery within weeks before first dose of study drug Major surgery within weeks of first dose of study drug Subjects who have had major surgery (such as nephrectomy) or chemotherapy within weeks prior to first dose of drug Major surgery within weeks of first dose of study drug Major surgery within weeks of drug administration Had major surgery within weeks prior to study drug treatment. Major surgery within weeks of first dose of study drug Major surgery within weeks of first dose of study drug Subjects who have had major surgery within weeks prior to first dose of drug Major surgery within weeks of study enrollment or planned major surgery during study and up to months after discontinuation of study drug Major surgery within weeks of first dose of study drug Has had major surgery to liver or other site within weeks prior to the first dose of study drug. Major surgery within weeks prior to first dose of study drug. Major surgery within weeks before first dose of study drug. Major surgery within weeks before first dose of study drug. major surgery within weeks of first dose of study drug Major surgery within weeks of the first dose of study drug Major surgery within weeks of first dose of study drug Major surgery within weeks before the first dose of study drug. Major surgery within weeks of first dose of study drug. Major surgery within weeks of first dose of study drug Major surgery within six weeks or open biopsy within days before drug infusion. Trauma or major surgery within weeks of first study drug administration Major surgery within weeks of first dose of study drug Major surgery within weeks of study drug administration Had major surgery within weeks of first dose of study drug Subjects who had major surgery within weeks of the first day of study drug. Major surgery within weeks of the first dose of study drug. Major surgery within weeks prior to first study drug administration Subjects that have undergone major surgery within weeks prior to the first dose of study drug are not eligible Major surgery within weeks before first dose of study drug. Major surgery within weeks before the first dose of study drug. Major surgery within weeks before first day of study drug dosing Major surgery or radiation therapy within weeks before first study drug administration. Major surgery planned within weeks of the first dose of study drug Major surgery within weeks prior to first study drug administration. Major surgery within weeks of st dose of study drug Major surgery within weeks of first dose of study drug. Major surgery within weeks of initiation of study drug Major surgery within six weeks or open biopsy within days before drug infusion. Major surgery within weeks before the first dose of either study drug Major surgery or significant trauma within weeks prior to the first dose of study drug. Prior major surgery within weeks of starting study drug administration Trauma or major surgery within weeks of first study drug administration Major surgery within weeks of first dose of study drug Major surgery within weeks of first dose of study drug EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Major surgery within weeks of first dose of study drug Had major surgery within weeks before study drug treatment Major surgery within weeks of first dose of study drug History of severe trauma or major surgery within weeks prior to the initiation of study drug administration.