At the time of registration: patients must have recovered from the toxic effects of prior therapy: >=  days from any investigational agent, >=  days from prior cytotoxic therapy, >=  days from vincristine, >=  days from nitrosoureas, >=  days from procarbazine administration, and >=  days for non-cytotoxic agents, e.g., interferon, tamoxifen, thalidomide, cis-retinoic acid, etc. (radiosensitizer does not count); any questions related to the definition of non-cytotoxic agents should be directed to the principal investigator
At the time of registration, subject must be removed from prior therapy as follows:\r\n* >=  days from any investigational agent,\r\n* >=  weeks ( days) from prior cytotoxic therapy,\r\n* >=  weeks ( days) from vincristine,\r\n* >=  weeks ( days) from nitrosoureas,\r\n* >=  weeks ( days) from procarbazine administration,\r\n* >=  week ( days) for non-cytotoxic agents, e.g., interferon, tamoxifen, thalidomide, cis-retinoic acid, etc. (radiosensitizer does not count)
At the time of treatment on protocol patients must have recovered from the toxic effects of prior therapy: >  days from any noncytotoxic investigational agent, >  days from prior cytotoxic therapy or Avastin, >  days from vincristine, >  days from nitrosoureas, >  days from procarbazine administration, and >  days for non-cytotoxic agents, e.g., interferon, tamoxifen, thalidomide, cis-retinoic acid, etc. (radiosensitizer does not count); any questions related to the definition of non-cytotoxic agents should be directed to the study chair
Patients must have recovered from the toxic effects of prior therapy: >  weeks for biologic therapies or non-cytotoxic therapies, >  weeks for cytotoxic therapies, and >  weeks for nitrosoureas; any questions related to the definition of non-cytotoxic agents should be directed to the study chair\r\n* NOTE:  cis-retinoic acid (Accutane) as biologic therapy has a washout period of  days
 week for non-cytotoxic agents, such as interferon, tamoxifen, & cis-retinoic acid
?  days elapsed from the administration of any prior cytotoxic agents, except ?  days from vincristine, ?  days from procarbazine, and ?  days from nitrosureas
?  days elapsed from administration of any non-cytotoxic agent (e.g., interferon, tamoxifen, thalidomide, cis-retinoic acid)
Insufficient time for recovery from prior therapy:\r\n* Less than  days from WBRT or SRS;\r\n* Less than  days from any investigational agent, \r\n* Less than  days from prior cytotoxic therapy (except  days from prior temozolomide,  days from vincristine,  days from nitrosoureas,  days from procarbazine, irinotecan or topotecan administration), and \r\n* Less than  days for non-cytotoxic agents, e.g., interferon, tamoxifen, thalidomide, cis-retinoic acid, etc. \r\n* When radiation necrosis is suspected, standard of care (SOC) confirmatory imaging, such as MRI perfusion, magnetic resonance (MR) spectroscopy and or positron emission tomography (PET) will be performed, and patients with findings consistent with radiation necrosis will be excluded
Patients must have sufficient time for recovery from prior therapy:  days from any investigational agent,  days from prior cytotoxic therapy (except  days from prior temozolomide,  days from vincristine,  days from nitrosoureas,  days from procarbazine administration), and  days for non-cytotoxic agents, e.g., interferon, tamoxifen, thalidomide, cis-retinoic acid, etc.
At the time of registration; patients must have recovered from the toxic effects of prior therapy:\r\n* >=  days from any investigational agent\r\n* >=  days from prior cytotoxic therapy\r\n* >=  days from vincristine\r\n* >=  days from nitrosoureas\r\n* >=  days from procarbazine administration\r\n* >  days from bevacizumab administration and\r\n* >=  days for non-cytotoxic agents, e.g., interferon, tamoxifen, thalidomide, cis-retinoic acid, etc. (radiosensitizer does not count); any questions related to the definition of non-cytotoxic agents should be directed to the Academic principal investigator (PI)
Patients must have recovered from the toxic effects of prior therapy, and there must be a minimum time of  days prior to registration from the administration of any investigational agent or prior cytotoxic therapy with the following exceptions:\r\n*  days from administration of vincristine\r\n*  days from administration of nitrosoureas\r\n*  days from administration of procarbazine
Cohort : Patients with recurrent WHO grade  glioma may have received prior external beam radiotherapy and/or chemotherapy; patients with stable WHO grade  glioma must have had prior chemotherapy (at least one cycle of temozolomide or procarbazine, lomustine, and vincristine [PCV]-based chemotherapy); with regard to the prior therapy in Cohort , patients may have had treatment for no more than  prior relapses; relapse is defined as progression following initial therapy (i.e. radiation +/- chemo if that was used as initial therapy) or observation of stable disease; the intent therefore is that patients may have had  prior therapies (initial therapy and treatment for  relapses); if the patient had a surgical resection for relapsed disease, and no anti-cancer therapy was instituted for up to  weeks, and the patient undergoes another surgical resection, this is considered as  relapse\r\n* In Cohort  with recurrence, tumor recurrence is defined by the increase of maximum tumor diameter, based on the axial and/or coronal T or FLAIR MR images; increase of tumor size can be based on comparison with previous scans performed up to prior  years to allow assessment of slow-growth of the tumor\r\n* In Cohort , patients must have recovered from the toxic effects of prior therapy:  weeks from any investigational agent,  weeks from prior cytotoxic therapy and/or at least two weeks from vincristine,  weeks from nitrosoureas,  weeks from procarbazine administration, and  week for non-cytotoxic agents, e.g., interferon, tamoxifen, thalidomide, cis-retinoic acid, etc. (radiosensitizer does not count); any questions related to the definition of non-cytotoxic agents should be directed to the Principal Investigator; with regard to previous RT, there must be at least  months from the completion of RT (or radiosurgery)
Insufficient time for recovery from prior therapy:\r\n* Less than  days from any investigational agent, \r\n* Less than  days from prior cytotoxic therapy (except  days from prior temozolomide,  days from vincristine,  days from nitrosoureas,  days from procarbazine administration), and \r\n* Less than  days for non-cytotoxic agents, e.g., interferon, tamoxifen, thalidomide, cis-retinoic acid, etc. (radiosensitizer does not count)
Patients must have sufficient time for recovery from prior therapy:  days from any investigational agent,  days from prior cytotoxic therapy (except  days from prior temozolomide,  days from vincristine,  days from nitrosoureas,  days from procarbazine administration), and  days for patients who received metronomic chemotherapy or non-cytotoxic agents, e.g., bevacizumab, interferon, tamoxifen, thalidomide, cis-retinoic acid, etc. (radiosensitizer does not count)
Patients must have recovered from the toxic effects of prior therapy to < grade  non hematological or grade  or lesser hematological toxicity per CTC ver  (except deep vein thrombosis):  weeks from prior cytotoxic therapy and/or at least two weeks from vincristine,  weeks from nitrosoureas,  weeks from procarbazine administration, and  week for non-cytotoxic agents, e.g., interferon, tamoxifen, cis-retinoic acid, etc. (radiosensitizer does not count). Patients who receive anticancer agents for non-therapeutic purposes unrelated to this study
 week for non-cytotoxic agents (e.g., interferon, tamoxifen, & cis-retinoic acid)
Patients must have recovered from the toxic effects of prior therapy:  weeks from prior cytotoxic therapy and/or at least two weeks from vincristine,  weeks from nitrosoureas,  weeks from procarbazine administration, and  week for non-cytotoxic agents, e.g., interferon, tamoxifen, thalidomide, cis-retinoic acid, etc. (radiosensitizer does not count). Any questions related to the definition of non-cytotoxic agents should be directed to the Study Chair.
Must be  days from administration of non-cytotoxic agents (e.g., bevacizumab (except COHORT b), interferon, tamoxifen, thalidomide, cis-retinoic acid, tyrosine kinase inhibitor, etc.).
Patients must have recovered from the toxic effects of prior therapy, and there must be a minimum time of: \r\n*  days from the administration of any investigational agent\r\n*  days from administration of prior cytotoxic therapy with the following exceptions: \r\n**  days from administration of vincristine\r\n**  days from administration of nitrosoureas\r\n**  days from administration of procarbazine\r\n*  days from administration of non-cytotoxic agents (e.g., interferon, tamoxifen, thalidomide, cis-retinoic acid, etc. [radiosensitizer does not count])\r\n*  days from prior radiation therapy
Patients must have recovered from the toxic effects of prior therapy:  weeks from prior cytotoxic therapy and/or at least  weeks from vincristine,  weeks from nitrosoureas,  weeks from procarbazine administration, and  week for non-cytotoxic agents, e.g., interferon, tamoxifen, thalidomide, cis-retinoic acid, etc. (radiosensitizer does not count),  weeks for experimental biologic agents (epidermal growth factor receptor [EGFR] inhibitors, etc) and  weeks from Gliadel implantation
Patients must have recovered from the toxic effects of prior therapy:\r\n -  weeks from any investigational agent\r\n -  weeks from prior cytotoxic therapy (except  weeks from nitrosoureas,  weeks from procarbazine,  weeks from vincristine)\r\n -  weeks for non-cytotoxic or biologic agents e.g., interferon, tamoxifen, thalidomide, cis-retinoic acid, tarceva, etc; note a -week washout is required for prior treatment with bevacizumab
 days from administration of procarbazine
 days from administration of non-cytotoxic agents [e.g., interferon, tamoxifen, thalidomide, cis-retinoic acid, etc. (radiosensitizer does not count)]