Are administered treatment with any other investigational agent or participation in another clinical study with anti-cancer therapeutic intent Participation in another therapeutic clinical study or receiving any investigational agent within days of enrollment or during this clinical study Treatment with any other investigational agent or participation in another clinical study with therapeutic intent Participated in a therapeutic clinical study within weeks before study drug treatment, or current participation in other therapeutic investigational procedures. Treatment with any other investigational agent or participation in another clinical trial with therapeutic intent within days or five half-lives of the drug prior to enrollment Treatment with any other investigational agent or participation in another clinical study with therapeutic intent within days prior to randomization Patients who participated in any therapeutic clinical study with an investigational agent within the last days Treatment with any other investigational agent or participation in another clinical trial with therapeutic intent within days prior to enrollment Participation in an investigational therapeutic drug trial within days of study entry Patients treated on any other therapeutic clinical protocols within days prior to registration or during participation in the study Participated in a therapeutic clinical study within weeks before study drug treatment, or current participation in other therapeutic investigational procedures. Patients treated on any other therapeutic clinical protocols within days prior to study entry or during participation in the study Patients treated on any other therapeutic clinical protocols within weeks of registration Patients treated on any other therapeutic clinical protocols within days prior to study entry or during participation in the study Treatment with any other investigational agent or participation in another clinical study with therapeutic intent within days prior to Cycle Day . For Phase b, participants who have received the following prior antitumor therapy: received nitrosoureas and mitomycin C within weeks Concurrent participation in an investigational drug trial with therapeutic intent defined as prior study therapy within days prior to start of this study Treatment with any anticancer therapy or participation in another therapeutic clinical study with investigational drugs