Patients who have had significant traumatic injury within days prior to enrollment are not eligible Significant traumatic injury within weeks prior to planned initiation of study therapy Traumatic injury within weeks before initiation of study treatment Major surgery or significant traumatic injury within days prior to therapy Patients who have had a major surgery or significant traumatic injury within weeks of start of study drug Traumatic injury or palliative radiotherapy within weeks prior study treatment initiation Major surgery or significant traumatic injury within days prior to enrollment Patients who have had major surgical procedures or significant traumatic injury within days prior to study treatment =< days before first dose of protocol-indicated treatment:\r\n* Anti-cancer treatment with bevacizumab.\r\n* Major surgery requiring general anesthesia or significant traumatic injury. Stem cell infusion without traumatic brain injury Major surgery or significant traumatic injury within days prior to Cycle Day Major surgery or significant traumatic injury occurring within days prior to treatment Or a traumatic brain injury will be excluded Major surgery or significant traumatic injury within weeks of run-in Major surgery or significant traumatic injury occurring within days prior to treatment Significant traumatic injury within the past weeks. Failure to recover from major surgery or traumatic injury within weeks or minor surgery within weeks prior to Day of treatment. Major surgery or significant traumatic injury within weeks of starting study treatment. Major surgery or significant traumatic injury within weeks of starting study treatment. Major surgery or significant traumatic injury within weeks of first study drug Patients who have had a major surgery or significant traumatic injury within weeks from day of study drug Major surgery or significant traumatic injury within weeks prior to study entry. undergone major surgery or suffered from significant traumatic injury Major surgery, or significant traumatic injury occurring within days prior to treatment Major surgery or significant traumatic injury within weeks of first study drug; a core pancreatic or liver biopsy does not preclude the patient from the study Major surgery, or significant traumatic injury within weeks prior to study entry Major surgery or significant traumatic injury within weeks of starting study treatment. Major surgery or significant traumatic injury within weeks of first study drug Patients who have had a major surgery or significant traumatic injury within weeks of start of study drug, Major surgery or traumatic injury within days of randomization Major surgery or significant traumatic injury within days of Cycle Day . Significant traumatic injury or major surgery (major surgery means opening of a body cavity, eg, thoracotomy, laparotomy, laparoscopic organ resection, and major orthopedic procedures, eg, joint replacement, open reduction and internal fixation) within days of scheduled dosing day ; Significant traumatic injury within weeks prior to initiation of study treatment Major surgery or significant traumatic injury within weeks of first study treatment from which the subject has not fully recovered Major surgery or significant traumatic injury within weeks of starting study treatment. Significant traumatic injury within weeks before Cycle , Day Patients with a history of traumatic brain injury prior to tumor diagnosis are not eligible Participant has a history of neurologic event (i.e. traumatic brain injury) unrelated to cancer or its treatment Major surgery or significant traumatic injury occurring within weeks before randomization History of traumatic brain injury