The patient has uncontrolled or poorly controlled hypertension despite standard medical management as defined in this protocol Patients with poorly controlled hypertension on multiple antihypertensives Poorly controlled hypertension despite anti-hypertensive medications Has uncontrolled or poorly controlled hypertension Poorly controlled Type diabetes mellitus Patient has poorly controlled hypertension and on multiple antihypertensives Presence of poorly controlled diabetes mellitus (glycated hemoglobin [HgbAc] > .%). Uncontrolled dysrhythmias or poorly controlled angina. Has poorly controlled diabetes mellitus (HbAc >% or random glucose >mg/dL) Uncontrolled dysrhythmias or poorly controlled angina. Have poorly controlled diabetes defined as HbAc values of> .%. Participants with preexisting, well-controlled diabetes are not excluded. Poorly controlled hypertension despite multiple antihypertensive medication or Uncontrolled intercurrent illness including, but not limited to, active infection, poorly controlled hypertension, diabetes mellitus or other serious medical or psychiatric conditions that could interfere with adherence to or completion of this study Poorly controlled diabetes mellitus Patient with poorly controlled hypertension despite multiple antihypertensives Significant cardiovascular disease including Congestive Heart Failure or poorly controlled hypertension. Poorly controlled diabetes mellitus Poorly-controlled diabetes mellitus (DM) Poorly-controlled DM Poorly controlled hypertension despite anti-hypertensive medications Poorly controlled hypertension Patients with poorly controlled hypertension and on multiple antihypertensives Uncontrolled or poorly controlled hypertension. Diabetic patients with poorly controlled diabetes. Patient has poorly controlled diabetes mellitus with a glycosylated hemoglobin > % or poorly controlled steroid-induced diabetes mellitus with a glycosylated hemoglobin of > % Participants with poorly controlled diabetes or with evidence of clinically significant diabetic vascular complications Poorly controlled diabetes Have poorly controlled diabetes Diabetes that is poorly controlled Poorly controlled diabetes History or evidence of poorly controlled hypertension Poorly controlled hypertension Poorly controlled diabetes mellitus Patient has poorly controlled hypertension and on multiple antihypertensives Patients with poorly controlled hypertension despite multiple antihypertensive medications Patients with poorly controlled hypertension despite hypertensive medication Significant cardiovascular disease including CHF, leptomeningeal disease, poorly controlled hypertension, or an MI within months prior to dosing. Patients with poorly controlled hypertension No poorly controlled intercurrent illness including, but not limited to, ongoing or active infection, poorly controlled diabetes, symptomatic congestive heart failure, or psychiatric illness that in the opinion of the investigator would limit compliance with study requirements Significant cardiovascular disease including CHF or poorly controlled hypertension. Has poorly controlled diabetes mellitus defined as HbAc > .%. Significant cardiovascular disease including CHF or poorly controlled hypertension. Inadequately controlled hypertension Poorly controlled Type or diabetes Poorly controlled diabetes as defined by a fasting serum glucose > . x ULN. Must not have poorly controlled diabetes mellitus, known central nervous system involvement by malignant disease or insufficient bone marrow, renal, or hepatic function Patients with poorly controlled diabetes Patient has poorly controlled diabetes mellitus (HbAc > %) Poorly controlled diabetes mellitus; d. Poorly controlled diabetes mellitus (HbAC >.%); Poorly-controlled hypertension Poorly controlled high blood pressure Uncontrolled or poorly controlled diabetes Patient has poorly controlled diabetes mellitus with a glycosylated hemoglobin > % or poorly controlled steroid-induced diabetes mellitus with a glycosylated hemoglobin of > % Poorly controlled intercurrent illnesses Active psychosis or poorly controlled depression in the past months Any suicide attempt or poorly controlled depression in the past months Poorly controlled diabetes Poorly controlled diabetes mellitus Poorly controlled diabetes mellitus (fasting blood glucose > ) Significant cardiovascular disease including CHF or poorly controlled hypertension. Poorly controlled hypertension, with blood pressure at study entry > / Major or chronic medical disease, including heart disease, poorly controlled diabetes, etc., to be adjudicated by the principal investigator Major or chronic medical disease, including heart disease, poorly controlled diabetes, etc., to be adjudicated by the principal investigator Poorly controlled hypertension, DM or other serious medical/psychiatric illness Poorly controlled diabetes mellitus (defined as HbAc > %)