Patients may not be receiving Coumadin while on treatment; other anticoagulants are allowed Patients receiving anticoagulation therapy with Coumadin are not eligible for study; (patients on non-coumadin anticoagulants [Lovenox, Xarelto, etc.] are eligible for study; patients on Coumadin who can be transitioned to Lovenox prior to starting study treatments will be eligible) Ongoing treatment with Coumadin. Current treatment with therapeutic doses of Coumadin-derivative anticoagulants (low dose Coumadin up to mg PO daily for deep vein thrombosis prophylaxis is allowed) Inability to stop antiplatelet and Coumadin therapy for days prior to and days post treatment with the NanoKnife system If subject is receiving Coumadin (warfarin), a stable international normalization ratio (INR) of - is required. Patients who are currently taking Coumadin or Coumadin derivatives Current use of therapeutic doses of warfarin sodium or any other coumadin-derivative anticoagulants; heparin and/or low molecular weight heparins or other anticoagulants are allowed Current use of therapeutic doses of warfarin sodium or any other coumadin-derivative anticoagulants; heparin and/or low molecular weight heparins are allowed Patients on Coumadin must be changed to Lovenox at least week prior to starting capecitabine; low dose ( mg) Coumadin is allowed; intravenous and low-molecular weight heparin are permitted Patients who are currently taking therapeutic doses of warfarin sodium or any other coumadin-derivative anticoagulant Patients taking Coumadin, other agents containing warfarin, rivaroxaban, or dabigatran; (exception: low dose Coumadin [ mg or less daily] administered prophylactically for maintenance of in-dwelling lines or ports is allowed) Patients who are currently taking therapeutic doses of warfarin sodium or any other Coumadin-derivative anticoagulant Patients who require coumadin administration. Use of anti-coagulants such as coumadin, heparin, or Lovenox within days before treatment Patients who cannot discontinue Plavix, Coumadin or other anti-platelet or anti-coagulant medications Current use of warfarin sodium or any other coumadin-derivative anticoagulant; participant must be off coumadin-derivative anticoagulants for at least days prior to planned start of study treatment; low molecular weight heparin and factor Xa inhibitors are allowed Patients who are currently taking Coumadin or Coumadin derivatives other than to maintain patency of venous access lines. Patients who are currently taking therapeutic doses of warfarin sodium or any other coumadin-derivative anticoagulant Current use of warfarin sodium or any other coumadin-derivative anticoagulant; participants must be off coumadin-derivative anticoagulants for at least days prior to starting study drug; low molecular weight heparin is allowed Full anti-coagulant therapy Coumadin; patients may be receiving therapeutic Lovenox, Fragmin, or other heparin product that does not require laboratory monitoring Evidence of coagulopathy or bleeding diathesis; therapeutic anticoagulation for prior thromboembolic events is permitted; patients who are currently taking therapeutic doses of warfarin sodium or any other Coumadin-derivative anticoagulant are ineligible Use of coumadin or any other anticoagulant, unless anticoagulation can be temporarily reversed or stopped for a window of at least days peri-procedure Patients who are currently taking therapeutic doses of warfarin sodium or any other Coumadin-derivative anticoagulant Patients receiving warfarin (Coumadin) Patients receiving Coumadin Patients who are taking Coumadin or Coumadin derivatives. Treatment with Coumadin; patients who recently received Coumadin must be off Coumadin for at least days prior to start of the study Current therapeutic anticoagulation with Coumadin (warfarin) Patient is using warfarin or any other Coumadin-derivative anticoagulant; patients must be off Coumadin-derivative anticoagulants for at least seven days prior to starting the study drug; low molecular weight heparin is allowed Patients who are currently taking therapeutic doses of warfarin sodium or any other coumadin-derivative anticoagulant Patients for whom prophylactic anticoagulation therapy (eg. or mg aspirin PO daily or warfarin (Coumadin) - mg/day, or any other coumarin-derivative anticoagulants) is not an option unless due to thrombocytopenia Patients who are currently taking therapeutic doses of warfarin sodium or any other Coumadin-derivative anticoagulant; patients who can be safely changed to enoxaparin or other non-warfarin derived anti-coagulant and who otherwise meet eligibility requirements may be enrolled Participants requiring the use of therapeutic doses of warfarin (Coumadin) Patients may not be receiving Coumadin while on treatment; other anticoagulants are allowed Patients who are currently taking therapeutic doses of warfarin sodium or any other Coumadin-derivative anticoagulant Patient is receiving warfarin (Coumadin) Treatment with Coumadin or other anti-coagulant therapy (except aspirin) < weeks prior to enrollment Patients with an active bleeding tendency or are receiving any treatment with therapeutic doses of sodium warfarin (Coumadin) or coumadin derivatives; patients will be allowed to enter study on aspirin doses of mg/d Patients who require therapeutic doses of Coumadin derivative anticoagulants such as warfarin are excluded; low molecular weight heparin is permitted, provided the patients PT/INR is =< .; Coumadin doses of up to mg daily are permitted for prophylaxis of thrombosis Active bleeding diathesis or current treatment with therapeutic doses of sodium warfarin (Coumadin) or other vitamin K active agents (Note: mini-dose of Coumadin (e.g., mg/day) or anti-coagulants given to maintain intravenous line patency, as well as unfractionated or low molecular weight heparin therapy are permitted) Patients who are currently taking Coumadin are not eligible use of coumadin or any other anticoagulant, unless anticoagulation can be temporarily reversed or stopped; Patients who are currently taking therapeutic doses of warfarin sodium or any other coumadin-derivative anticoagulant; low molecular weight heparin is allowed Ongoing anticoagulant therapy (eg, aspirin, coumadin, heparin). Ongoing anticoagulant therapy (eg, aspirin, coumadin, heparin). Currently receiving warfarin or other coumadin-derived anticoagulants for treatment, prophylaxis or otherwise. Patients who require treatment with therapeutic doses of coumadin-type anticoagulants (maximum daily dose of mg allowed for port line patency permitted). Patient must not be on full dose Coumadin Patients with thromboembolic disease cannot be on Coumadin, but low molecular heparins are allowed Patients who are currently receiving treatment with warfarin sodium (Coumadin) or any other coumarin-derivative anti-coagulants Therapeutic treatment with Coumadin or any other coumarin-derivative anticoagulant Subjects receiving Coumadin anticoagulants No concurrent warfarin or Coumadin-derivatives Patients on therapeutic doses of Coumadin or Lovenox are ineligible to participate in study Current treatment with warfarin sodium or any other Coumadin-derivative anticoagulant Patients for whom prophylactic anticoagulation therapy (eg. mg aspirin PO daily or warfarin [Coumadin] - mg/day, or any other coumarin-derivative anticoagulants) is not an option Patients who are currently taking therapeutic doses of warfarin sodium or any other Coumadin-derivative anticoagulant Use of Coumadin (warfarin) or other vitamin-K antagonists for anticoagulation; non-Coumadin anticoagulation is permitted Use of full anticoagulant doses of coumadin or heparin (exception: mg/day of coumadin for preventing catheter clots is allowed) Use of anticoagulant agent (warfarin, Coumadin, Jantoven, Marevan, Lawarin, Waran, or Warfant) Patient is using warfarin or any other Coumadin-derivative anticoagulant or vitamin K antagonists; patients must be off warfarin-derivative anticoagulants for at least seven days prior to starting the study drug; low molecular weight heparin is allowed; patients with congenital bleeding diathesis are excluded Participant is currently receiving treatment with anticoagulants (e.g. Coumadin) No concurrent full dose anticoagulant therapy; =< mg/day of Coumadin for preventing catheter clots allowed Patients taking Coumadin, Pradaxa or other blood thinner drugs Use of Coumadin or acenocoumarol at time of screening Women on Coumadin, Xarelto, or other anticoagulants Use of anticoagulation medications, including but not limited to coumadin, warfarin, plavix Use of any anticoagulation medications, such as warfarin or Coumadin Subjects on Coumadin or other anticoagulants Concurrent use of anticoagulants (i.e. Coumadin/warfarin) Any consumption of prescription anticoagulants, including Coumadin and Lovenox, during the weeks prior to baseline RPFNA History of a bleeding tendency or current use of Coumadin or other anticoagulants Individual may not be receiving any other investigational agents, antiplatelet agents (e.g. aspirin, clopidogrel [Plavix or others]), anticoagulants (e.g. heparin or heparinoids, Coumadin, or others), methotrexate, lithium Patients on blood thinners (aspirin or Coumadin) will be asked to stop medications days prior to surgery; in the case of Coumadin, patients are switched to Lovenox days prior to surgery and this is stopped the day before surgery; following surgery aspirin or Coumadin are recommenced hours post operation (postop) Ongoing therapy with any anticoagulant or antiplatelet agents (example, aspirin, clopidogrel, coumadin, heparin, or warfarin) that cannot be held to permit tumor biopsy).