Urine protein: creatinine (UPC) ratio < or urine dipstick for proteinuria =< + (note: if the UPC ratio is >= . then a -hour urine collection should be performed and this must demonstrate =< g of protein in hours) Within weeks prior to registration: Screening urine dipstick must equal or trace; if urine dipstick results are >= +, or if dipstick was not performed, calculation of urine protein creatinine (UPC) is required and patients must have a UPC ratio =< to participate in the study Urine protein creatinine (UPC) =< ; if UPC >= , then a -hour urine protein must be assessed; eligible patients must have a -hour urine protein value < g/L Within days prior to registration: Urine protein creatinine (UPC) ratio must be < . gm; if UPC ratio >= , collection of -hour urine measurement of urine protein is recommended (-hour urine protein level must be < mg for patient enrollment); UPC ratio of spot urine is an estimation of the -hour urine protein excretion a UPC ratio of is roughly equivalent to a -hour urine protein of gm Urine protein to creatinine ratio < OR -hour urine protein < g Urine Protein to Creatinine Ratio (UPC) < Urine protein to creatinine ratio of < , a urinalysis that is negative for protein, or a -hour urine protein level < mg/dL Urine protein: creatinine ratio =< , within days before the first dose of cabozantinib Urine protein/creatinine ratio of less than Patients with central pulmonary metastases or recent hemoptysis (>= / tea spoon [tsp] of red blood) within days of registration\r\n* Patients with clinically significant proteinuria (i.e. > grade ) or urine protein to creatinine ratio (UPC) ratio above .\r\n* Patients with suspicion of transmural tumor bowel involvement based on the investigator's discretion may not enroll on this study Urine protein < mg or urine protein: creatinine ratio (UPC) <.; and Urine protein to creatinine ratio =< (if urine protein creatinine ratio is > , then a -hour urine total protein must be assessed; subjects will be ineligible if the -hour urine protein is found to be > gm) Urine protein:creatinine ratio >= . at screening Within days prior to administration of study treatment: Urine protein: creatinine ratio (UPC) of =< Urine protein to creatinine (UPC) ratio =< (Bevacizumab-related exclusion) Proteinuria as demonstrated by a urine protein:creatinine (UPC) ratio >= . at screening Urine protein creatinine (UPC) ratio of < Proteinuria as demonstrated by a urine protein:creatinine (UPC) ratio >= . at screening A urine protein:creatinine ratio of < or < g protein on -hour urine collection Urine protein/creatinine ratio =< OR -hour urine protein < . gram obtained =< days prior to registration Urine protein/creatinine ratio =< Urine protein screened by urine analysis for urine protein creatinine (UPC) ratio; for UPC ratio > ., -hour urine protein must be obtained and must be < mg PHASE I STUDY ELIGIBILITY CRITERIA:\r\nSpot urine protein/creatinine ratio =< OR hour urine protein =< mg PHASE II COLORECTAL CANCER COHORT (MEDI+C ONLY):\r\nSpot urine protein/creatinine ratio =< OR hour urine protein =< mg Urine protein creatinine (UPC) < or, if UPC >= , -hour urine protein < g; use of urine dipstick for renal function assessment is not acceptable Urine protein should be screened by dipstick or urine analysis; for proteinuria > + or urine protein: creatinine ratio > ., -hour urine protein should be obtained and the level should be < mg for patient enrollment Urine protein creatinine ratio as determined by urinalysis of < . (for urine protein creatinine ratio of > ., -h urine protein must have been < gram) Urine protein:creatinine ratio >= . at screening Urine protein : creatinine ratio >= . at screening Urine protein to creatinine ratio (UPC) < ; if UPC >= , then a -hour urine protein must be assessed; subjects must have a -hour urine protein value < g to be eligible; use of urine dipstick for renal function assessment is not acceptable Proteinuria at screening as demonstrated by either urine protein: urine protein creatinine (UPC) ratio >= . or hr collection > g/hr at screening Urine protein to creatinine ratio (UPC) < ; NOTE: if UPC >= , then a -hour urine protein must be assessed; subjects must have a -hour urine protein value < g to be eligible Urine protein =< + or urine protein to creatinine ratio =< ; if urine protein:creatinine (UPC) ratio is > on urinalysis, then -hour urine collection from protein must be obtained and level must be < , mg for patient enrollment Urine protein:creatinine ratio (UPC) =< mg/mmol; ONLY APPLICABLE for patients with NF mutation (GSK) Urine protein: creatinine ratio (UPC) of =< ; UPC is the preferred test Urine protein: creatinine ratio urine protein creatinine (UPC) of =< OR less than or equal to + proteinuria on two consecutive dipsticks taken no less than week apart; UPC is the preferred test; patients with + proteinuria on dipstick must also have a -hour urine collection demonstrating protein of =< mg over hours Urine protein/creatinine ratio (UPCR) =< ; if urine/protein creatinine (UPC) >= , then a -hour urine protein must be assessed; eligible patients must have a -hour urine protein value < g/L Urine protein/creatinine ratio < or -hour urine < gram Urine protein should be screened by dipstick analysis; if protein >= + on dipstick, then urine protein creatinine (UPC) ratio should be calculated; if UPC ratio > ., -hour urine protein should be obtained and the level should be < mg/ hours for patient enrollment Patients with clinically significant proteinuria (urine protein creatinine ratio greater or equal to .) Urine protein/creatinine ratio =< (or protein =< + on urinalysis or hour urine protein =< gram/ hours) Urine protein to urine creatinine ratio (UPC) should be less than ; if greater than , then hour urine protein must be less than g for patient to be eligible Subjects must have a urine protein/creatinine (UPC) ratio < ; if UPC >= , then a -hour urine total protein must be obtained; subjects must have a -hour urine protein value < g to be eligible; use of urine dipstick for renal function assessment is not acceptable Urine protein creatinine (UPC) < (in like units) or, if UPC >= , -hour urine protein < g; use of urine dipstick for renal function assessment is not acceptable Urine protein creatinine (UPC) ratio < OR urine protein =< + Urine protein/creatinine ratio >= . Patients are excluded if they have proteinuria at screening as demonstrated by either:\r\n* Urine dipstick for proteinuria >= + (patients discovered to have >= + proteinuria on dipstick urinalysis at baseline should undergo a hour urine collection and must demonstrate =< g of protein in hours to be eligible) OR\r\n* Urine protein: creatinine (UPC) ratio >= . at screening; for UPC ratio > , a hour urine protein should be obtained and the level should be < mg; NOTE: urine protein should be screened by urine analysis for UPC ratio; a UPC ratio of is roughly equivalent to a -hour urine protein of g Urine protein: creatinine ratio ? . at screening Urine protein/creatinine (UPC) ratio < . within days prior to registration; if the UPC ratio is >= . then the patients should undergo a -hour urine collection and must demonstrate =< g of protein in hours to be eligible) Urine protein:creatinine ratio =< . at screening Urine protein (albumin)/creatinine ratio of < . Grade or higher proteinuria (+ or higher protein on urinalysis or urine protein:creatinine (UPC) ratio >= .; if both tests are performed, UPC should be used to evaluate eligibility) or hematuria Urine protein-to-creatinine (UPC) ratio =< mg/mg or -hour urine protein < g Urine protein creatinine (UPC) ratio must be < . gm Urine protein to creatinine ratio (UPC) < (tested within days prior to registration)\r\n* If UPC >= , then a -hour urine protein must be assessed; subjects must have a -hour urine protein value < g to be eligible; use of urine dipstick for renal function assessment is not acceptable -hour urine protein, if required < g (tested within days prior to registration)\r\n* If UPC >= , then a -hour urine protein must be assessed; subjects must have a -hour urine protein value < g to be eligible; use of urine dipstick for renal function assessment is not acceptable Urine protein to creatinine ratio of < prior to registration Urine protein to creatinine ratio < , or, -hour urine protein < g; if urine protein to creatinine (UPC) >= , then a -hour urine protein must be assessed; patients must have a -hour urine protein value < g to be eligible; use of urine dipstick for renal function assessment is not acceptable Urine protein: creatinine ratio > Urine protein to creatinine ratio (UPC) < \r\n* Or, -hour urine protein < g\r\n* If UPC >= , then a -hour urine protein must be assessed; subjects must have a -hour urine protein value < g to be eligible Urine protein =< + OR urine protein to creatinine (UPC) ratio =< ; if UPC ratio is > on urinalysis, then -hour urine collection for protein must be obtained and level must be < , mg for patient enrollment Urine protein should be screened by urine analysis for urine protein creatinine (UPC) ratio; for UPC ratio > ., -hour urine protein should be obtained and the level should be < mg for patient enrollment; NOTE: UPC ratio of spot urine is an estimation of the -urine protein excretion; a UPC ratio of is roughly equivalent to a -hour urine protein of gm Urine protein: creatinine (UPC) ratio < . within days prior to registration OR urine dipstick for proteinuria =< positive (+) (patients discovered to have > + proteinuria on dipstick urinalysis at baseline must have a UPC ratio done that is < . to be eligible; if the UPC ratio is >= . then the patients should undergo a -hour urine collection and must demonstrate =< g of protein in hours to be eligible)\r\n* Note: UPC ratio of spot urine is an estimation of the -hour urine protein excretion; a UPC ratio of is roughly equivalent to a -hour urine protein of gm Urine protein to creatinine ratio (UPC) < ; if UPC >= , then a -hour urine protein must be assessed; patients must have a -hour urine protein value < g to be eligible Urine Protein Creatinine (UPC) ratio < . or hour urine protein ratio < mg Urine protein to creatinine ratio < ; or, -hour urine protein < g; if urine protein creatinine ratio (UPC) >= , then a -hour urine protein must be assessed; subjects must have a -hour urine protein value < g to be eligible; use of urine dipstick for renal function assessment is not acceptable Urine protein to creatinine ratio (UPC) < ; if UPC >= , then a -hour urine protein must be assessed; subjects must have a -hour urine protein value < g to be eligible Within days prior to registration: Urine protein/creatinine ratio should be =< Urine protein to creatinine ratio (UPC) =< ; a UPC is required only if the urine protein is > ; if UPC >, then a -hour urine protein must be assessed; subjects must have a -hour urine protein value < g to be eligible Urine protein:creatinine ratio of < Subjects with a urine protein/creatinine ratio greater than Urine protein to creatinine ratio (UPC) < Urine protein to creatinine (UPC) ratio of < assessed in a random or spot urine sample; if UPC >= , then a -hour urine protein must be assessed; patients must have a -hour urine protein value < gram to be eligible Proteinuria as demonstrated by a urine protein: creatinine (UPC) ratio >= . at screening Serum creatinine =< . x ULN or calculated creatinine clearance (CrCl) >= cc/min and random urine protein:creatinine ratio (UPC) < or -hour (hr) urine protein < g, within days of registration Urine protein to creatinine ratio (UPC) < (note, if >= , then a -hour urine protein must be assessed: if -hour urine protein > g, patient ineligible) Urine protein: creatinine ratio greater than or equal to . Urine protein to urine creatinine ratio (UPC) < .; if UPC >= then a hour urine protein must be assessed; subjects must have a -hour urine protein value < g to be eligible EXPANSION COHORT ONLY: Urine protein to urine creatinine ratio (UPC) < .; if UPC >= then a hour urine protein must be assessed; subjects must have a -hour urine protein value < g to be eligible Urine protein: creatinine ratio >= . at screening Less than or equal to + proteinuria on two consecutive dipsticks taken no less than week apart, OR < gm protein on -hour urine collection or a urine protein: creatinine ratio of < Urine protein/creatinine (UPC) ratio =< . unless the patient has a neobladder UPC ratio < . at screening or hours urine protein < gm (Appendix D) Routine urinalysis showing ?+ protein or protein/creatinine ratio <.. For proteinuria ?+ or urine protein/creatinine ratio ?., -hour urine must be collected and the level must be < gram of protein in hours for subject enrollment. Urine protein:creatinine ratio =< . OR -hour urine protein =< mg (-hour total urine protein only need be obtained if urine protein:creatinine ratio < .) Less than or equal to + proteinuria on two consecutive dipsticks taken no less than week apart, or < gm protein on -hour urine collection or a urine protein:creatinine ratio of < Urine protein creatinine (UPC) ratio < ; note: urine protein must be screened by urine analysis for UPC ratio; for UPC ratio >= ., -hour urine protein must be obtained and the level should be < , mg for registration If baseline urine protein creatinine (UPC) >= , a -hour urine protein must be assessed; patients must have a -hour urine protein value < grade (> . g/ hours) to be eligible Proteinuria, as demonstrated by a -hour protein of >= mg; urine protein will be screened by urine protein-creatinine ratio (UPC); for UPC ratio > ., a -hour urine protein will need to be obtained and the level should be < mg for patient enrollment Urine protein to creatinine (UPC) ratio < ; if UPC >= , then a -hour urine protein must be assessed; subjects must have a -hour urine protein value < g to be eligible Proteinuria as defined by positive urine dipstick for protein OR urine protein/creatinine (UPC) ratio >= .; if these criteria are not met, the patient must have a hour urine collection that demonstrates < gm protein over hours Creatinine less than or equal to . x ULN; if urine protein to creatinine ratio is greater than or equal to , a hour urine protein must be assessed; subjects must have a hour urine protein value less than g to be eligible; use of urine dipstick for renal function assessment is not acceptable Urine to protein to creatinine (UPC) ratio < ; if UPC > , then a -hour urine protein must be assessed; subjects must have a -hour urine protein value < g to be eligible Urine protein to creatinine (UPC) ratio < . or if >= ., -hour urine protein must be < mg Urine protein: creatinine (UPC) ratio < . within days prior to registration OR urine dipstick for proteinuria ? + (patients discovered to have > + proteinuria on dipstick urinalysis at baseline must have a UPC ratio done that is <. to be eligible. If the UPC ratio is ? . then the patients should undergo a -hour urine collection and must demonstrate ? g of protein in hours to be eligible). *Note: UPC ratio of spot urine is an estimation of the -hour urine protein excretion; a UPC ratio of is roughly equivalent to a -hour urine protein of gm. UPC ratio is calculated using one of the following formulas: Proteinuria as demonstrated by a urine protein creatinine (UPC) ratio >= . at screening Urine protein to creatinine ratio (UPC) < (evaluated within days of randomization); if UPC >= , then a -hour urine protein must be assessed; subjects must have a -hour urine protein value < g to be eligible Urine protein should be screened by dipstick analysis; if protein >= + on dipstick, then urine protein creatinine (UPC) ratio should be calculated; if UPC ratio > , -hour urine protein should be obtained and the level should be < mg/ hours for patient enrollment; Note: UPC ratio of spot urine is an estimation of the hour urine protein excretion- a UPC ratio of is roughly equivalent to a -hour urine protein of gm