Histologically- or cytologically-confirmed CRC that is metastatic Must have histologically confirmed advanced CRC that is metastatic. KRAS Mutant CRC: Advanced KRAS mutant CRC who have progressed or are ineligible for both irinotecan and oxaliplatin based chemotherapy KRAS Wild Type CRC: Advanced KRAS wild type CRC who have progressed or are ineligible for both irinotecan and oxaliplatin based chemotherapy and who are relapsed or refractory to at least prior systemic therapy that included an anti-EGFR antibody, such as cetuximab, panitumumab or others. Colorectal cancer (CRC) (not mismatch repair deficient by local assay including PCR and/or immunohistochemistry) Any advanced solid tumor, with the exception of colorectal carcinoma (CRC), which is Microsatellite Instability (MSI)-High (MSI-H) More than one prior line of systemic therapy for advanced CRC Must have immune checkpoint nave histologically/cytologically confirmed advanced or metastatic CRC. Colorectal carcinoma (CRC). Histologically or cytologically-confirmed diagnosis of metastatic KRAS wildtype colorectal cancer (CRC) Histologically- or cytologically- confirmed CRC Metastatic CRC Known or suspected high-frequency microsatellite instability (MSI-H) CRC Histologically- or cytologically-confirmed CRC Group : KRAS mutant CRC.(Part B) Histologically-confirmed metastatic CRC Phase expansion: MSI high CRC MSI status is, respectively, determined by examining CRC tumor. For CRC: For CRC, hemoglobin ?. g/dL For CRC, prior treatment with cetuximab or panitumumab Subjects with recurrent (unresectable) or metastatic CRC: Have histologically confirmed microsatellite stable (MSS) CRC. Histologically- or cytologically- confirmed CRC Metastatic or recurrent CRC Must not have received prior systemic chemotherapy for Stage IV CRC Retinoblastoma-positive, histologically proven CRC with measurable disease CRC: at least prior systemic regimens in the metastatic setting, and as appropriate in patients whose tumors are microsatellite instability-high (MSI-H), pembrolizumab as well. Histologically or cytologically confirmed diagnosis of CRC Metastatic CRC not amenable to surgical resection CRC (Colorectal cancer): Patients with metastatic CRC and known KRAS (Kirsten rat sarcoma viral oncogene homolog) status who are eligible for treatment with regorafenib in accordance with the approved labeling. Have a history of Stage IV Colorectal Cancer (CRC) with metastases to the liver only Have pathology-proven complete removal of all primary and liver metastatic CRC lesions. Subjects with positive margins will not be eligible for the study. Patient must have histologically or cytologically confirmed refractory colorectal cancer (CRC) Patients with solid tumor other than CRC. Stage I-III colorectal cancer (CRC). Patients who are at elevated risk for CRC, defined as having ever been diagnosed with CRC, a precancerous (adenomatous) polyp, or inflammatory bowel disease No history of CRC Individualswithpersonalhistoryofcolorectal cancer (CRC) or colorectal polyps Be non-adherent to one or more recommended screenings for BC, CC, or CRC by Medical Record Review (MRR) Individuals that fall within the age range for CRC screening surveillance from AHP Are eligible for CRC screening surveillance from AHP Are not eligible for CRC screening surveillance from AHP Have a terminal medical illness that would otherwise categorize them as inappropriate candidates for CRC screening; these are: the individual must have any of the following noted in their EPIC electronic medical records (EMR): personal history of CRC, colectomy, colostomy, or ileostomy FOLLOW-UP ASSESSMENTS: Must be non-adherent for CRC screening at the time of the educational program Previous diagnosis of CRC Up to date with CRC screening guidelines. Family history of CRC diagnosed before the age of years Personal history of CRC Pathologically or cytologically confirmed diagnosis of metastatic (stage IV) RAS wildtype CRC Patients with a history of CRC without clear evidence of metastatic disease who have completed their acute cancer-specific treatment Average-risk patients due for colorectal cancer (CRC) screening at the time of a primary care appointment who initiate a portal session within the two-week period following their visit A personal history of CRC Specific CRC risk factors, including:\r\n* First degree relative with CRC\r\n* Personal history of adenomatous polyps\r\n* Recent blood in stools\r\n* Currently taking medication for a diagnosis of dementia Patients currently receiving active therapy for any cancer, including CRC or NSCLC